scholarly journals Erratum for “Bilevel Data-Driven Modeling Framework for High-Dimensional Structural Optimization under Uncertainty Problems” by Subhrajit Dutta and Amir H. Gandomi

2021 ◽  
Vol 147 (7) ◽  
Author(s):  
Subhrajit Dutta ◽  
Amir H. Gandomi
2021 ◽  
Author(s):  
Joanna Elzbieta Handzlik ◽  
Manu Manu

Cellular differentiation during hematopoiesis is guided by gene regulatory networks (GRNs) thought to be organized as a hierarchy of bistable switches, with antagonism between Gata1 and PU.1 driving red- and white-blood cell differentiation. We utilized high temporal-resolution gene-expression data from in vitro erythrocyte-neutrophil differentiation and a predictive data-driven dynamical modeling framework to learn the architecture and dynamics of gene regulation in a comprehensive twelve-gene GRN. The inferred genetic architecture is densely interconnected rather than hierarchical. The analysis of model dynamics revealed that neutrophil differentiation is driven by C/EBPα and Gfi1 rather than PU.1. This prediction is supported by the sequence of gene upregulation in an independent mouse bone marrow scRNA-Seq dataset. These results imply that neutrophil differentiation is not driven by the Gata1-PU.1 switch but by neutrophil-specific genes instead. More generally, this work shows that data-driven dynamical modeling can uncover the causality of developmental events that might otherwise be obscured.


SPE Journal ◽  
2018 ◽  
Vol 23 (04) ◽  
pp. 1090-1104 ◽  
Author(s):  
Nastaran Bassamzadeh ◽  
Roger Ghanem

Summary Accurate, data-driven, stochastic models for fluid-flow prediction in hydrocarbon reservoirs are of particular interest to reservoir engineers. Being computationally less costly than conventional physical simulations, such predictive models can serve as rapid-risk-assessment tools. In this research, we seek to probabilistically predict the oil-production rate at locations where limited data are observed using the available data at other spatial points in the oil field. To do so, we use the Bayesian network (BN), which is a modeling framework for capturing dependencies between uncertain variables in a high-dimensional system. The model is applied to a real data set from the Gulf of Mexico (GOM) and it is shown that BN is able to predict the production rate with 86% accuracy. The results are compared with neural-network and co-Kriging methods. Moreover, BN structure enables us to select the most-relevant variables for prediction, and thus we managed to reduce the input dimension from 36 to 17 variables while preserving the same prediction accuracy. Similarly, we use the local-linear-embedding (LLE) method as a feature-extraction tool to nonlinearly reduce the input dimension from 36 to 10 variables with negligible loss in accuracy. Accordingly, we claim that BN is a valuable modeling tool that can be efficiently used for probabilistic prediction and dimension reduction in the oil industry.


IEEE Access ◽  
2021 ◽  
pp. 1-1
Author(s):  
Amirsaman Mahdavian ◽  
Alireza Shojaei ◽  
Milad Salem ◽  
Haluk Laman ◽  
Naveen Eluru ◽  
...  

2021 ◽  
Author(s):  
Benjamin Pfeuty ◽  
Emmanuel Courtade ◽  
Quentin Thommen

AbstractA common signature of cell adaptation to stress is the improved resistance upon priming by prior stress exposure. In the context of hyperthermia, priming or preconditioning with sublethal heat shock can be a useful tool to confer thermotolerance and competitive advantage to cells. In the present study, we develop a data-driven modeling framework that is simple and generic enough to capture a broad set of adaptation behaviors to heat stress at both molecular and cellular levels. The model recovers the main features of thermotolerance and clarifies the tradeoff principles which maximize the thermotolerance effect. It therefore provides an effective predictive tool to design preconditioning and fractionation hyperthermia protocols for therapeutic purpose.


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