AbstractElectrons on helium form a unique two-dimensional system on the interface of liquid helium and vacuum. A small number of trapped electrons on helium exhibits strong interactions in the absence of disorder, and can be used as a qubit. Trapped electrons typically have orbital frequencies in the microwave regime and can therefore be integrated with circuit quantum electrodynamics (cQED), which studies light–matter interactions using microwave photons. Here, we experimentally realize a cQED platform with the orbitals of single electrons on helium. We deterministically trap one to four electrons in a dot integrated with a microwave resonator, allowing us to study the electrons’ response to microwaves. Furthermore, we find a single-electron-photon coupling strength of $$g/2\pi =4.8\pm 0.3$$g∕2π=4.8±0.3 MHz, greatly exceeding the resonator linewidth $$\kappa /2\pi =0.5$$κ∕2π=0.5 MHz. These results pave the way towards microwave studies of Wigner molecules and coherent control of the orbital and spin state of a single electron on helium.