Plasma levels of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 are increased in the coronary circulation in patients with acute coronary syndrome

2001 ◽  
Vol 141 (2) ◽  
pp. 211-217 ◽  
Author(s):  
Yoichi Inokubo ◽  
Hiroyuki Hanada ◽  
Hiroshi Ishizaka ◽  
Tomohisa Fukushi ◽  
Takaatsu Kamada ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Matrix Metalloproteinase ◽  
Plasma Levels ◽  
Coronary Circulation ◽  
Matrix Metalloproteinase 9 ◽  
Tissue Inhibitor Of Metalloproteinase ◽  
Tissue Inhibitor ◽  
Coronary Syndrome ◽  
Metalloproteinase 9

scholarly journals Plasma matrix metalloproteinase-9 and tissue inhibitor of matrix metalloproteinase-1 as prognostic biomarkers in critically ill patients

Open Medicine ◽  
2020 ◽  
Vol 15 (1) ◽  
pp. 50-56
Author(s):  
Izabela Duda ◽  
Łukasz Krzych ◽  
Halina Jędrzejowska-Szypułka ◽  
Joana Lewin-Kowalik
Keyword(s):  
Matrix Metalloproteinase ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Plasma Levels ◽  
Matrix Metalloproteinase 9 ◽  
Prognostic Biomarkers ◽  
Tissue Inhibitor Of Metalloproteinase ◽  
Tissue Inhibitor ◽  
Matrix Metalloproteinase 1 ◽  
Metalloproteinase 9

AbstractMatrix metalloproteinase 9 (MMP-9) plays an important role in inflammatory and pathological processes by enabling the inflow of leukocytes to the site of infection or tissue damage. MMP-9 and tissue inhibitor of metalloproteinase 1 (TIMP-1) have been described as potential prognostic biomarkers in various clinical settings. The aim of the study was to evaluate the usefulness of plasma levels of MMP-9 and TIMP-1 as well as the MMP-9/ TIMP-1 ratio in predicting the outcome in patients admitted to the intensive care unit (ICU). The study included 56 critically ill patients with multiple organ failure. Plasma levels of MMP-9 and TIMP-1 were determined on hospitalization day 1, 2, 3 and 7. Nineteen (35.7%) patients died. The level of TIMP-1 was statistically significantly higher on day 1 and 7 of hospitalization in non-survivors, as compared to survivors (p=0.01). A statistically significant positive correlation was found between MMP-9 and TIMP-1. The MMP-9/TIMP-1 ratio was comparable in both groups during of observation (0.62 on day 1). The MMP-9/TIMP-1 ratio was positively correlated with the level of lactate and negatively correlated with platelet count. Likewise, TIMP-1 was positively correlated with the level of lactate. The level of MMP-9 was higher in the non-survivor group only on day 7 of observation. In conclusion, although TIMP-1 and MMP-9 concentrations were higher in non-survivors and the MMP-9/TIMP-1 ratio was related to some parameters of critical illness, further research is needed to verify whether they can serve as reliable biomarkers for early prognostication of ICU patients.

scholarly journals Low IL-10 Plasma Levels, High IL-6 / IL-10 Ratio and Matrix Metalloproteinase-9 (MMP-9) Associated with high Cardiovascular Events in Acute Coronary Syndrome

2017 ◽  
Vol 10 (3) ◽  
pp. 1229-1238 ◽  
Author(s):  
Ketut Suryana ◽  
Wayan Wita ◽  
I. Gde Raka Widiana ◽  
Ketut Suastika ◽  
I. Wayan Putu Sutirtaya ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Matrix Metalloproteinase ◽  
Plasma Levels ◽  
Cardiovascular Events ◽  
Matrix Metalloproteinase 9 ◽  
Coronary Syndrome ◽  
Metalloproteinase 9

Matrix metalloproteinase-9 activity is associated to oxidative stress in patients with acute coronary syndrome

2010 ◽  
Vol 143 (1) ◽  
pp. 98-100 ◽  
Author(s):  
Alex Bittner ◽  
Hernán Alcaíno ◽  
Pablo F. Castro ◽  
Osvaldo Pérez ◽  
Ramón Corbalán ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Acute Coronary Syndrome ◽  
Matrix Metalloproteinase ◽  
Matrix Metalloproteinase 9 ◽  
Coronary Syndrome ◽  
Metalloproteinase 9
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