Functional outcome after shoulder arthroplasty for primary osteoarthritis: A multicenter study

AbstractThe main objective of this research work was to study the association of serum levels of growth factors (GF) and SDF-1α with the functional outcome and reduction of lesion volume in ischemic stroke patients. In this multicenter study, 552 patients with non-lacunar stroke (male, 62.1%; mean age, 68.2 ± 11.4) were included within 24 h from symptom onset. The main outcome variable was good functional outcome (modified Rankin Scale [mRS] ≤ 2) at 12 months. Secondary outcome variable was infarct volume (in mL) after 6 ± 3 months. Serum levels of VEGF, Ang-1, G-CSF, BDNF, and SDF-1α were measured by ELISA at admission, 7 ± 1 days, at 3 ± 1 months, and 12 ± 3 months. Except for BDNF, all GF and SDF-1α serum levels showed a peak value at day 7 and remained elevated during the first 3 months (all p < 0.01). High serum levels at day 7 of VEGF (OR, 19.3), Ang-1 (OR, 14.7), G-CSF (OR, 9.6), and SDF-1α (OR, 28.5) were independently associated with good outcome at 12 months (all p < 0.0001). On the other hand, serum levels of VEGF (B, − 21.4), G-CSF (B, − 14.0), Ang-1 (B, − 13.3), and SDF-1α (B, − 44.6) measured at day 7 were independently associated with lesion volume at 6 months (p < 0.01). In summary, high serum levels of VEGF, Ang-1, G-CSF, and SDF-1α at day 7 and 3 months after ischemic stroke are associated with good functional outcome and smaller residual lesion at 1 year of follow-up.

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Pyrocarbon interposition shoulder arthroplasty: preliminary results from a prospective multicenter study at 2 years of follow-up

Journal of Shoulder and Elbow Surgery ◽

10.1016/j.jse.2017.01.002 ◽

2017 ◽

Vol 26 (7) ◽

pp. 1143-1151 ◽

Cited By ~ 19

Author(s):

Jérôme Garret ◽

Arnaud Godeneche ◽

Pascal Boileau ◽

Daniel Molé ◽

Mikael Etzner ◽

...

Keyword(s):

Multicenter Study ◽

Shoulder Arthroplasty ◽

Prospective Multicenter Study ◽

Preliminary Results

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Subscapularis tenotomy versus lesser tuberosity osteotomy during total shoulder arthroplasty for primary osteoarthritis: a prospective, randomized controlled trial

Journal of Shoulder and Elbow Surgery ◽

10.1016/j.jse.2018.11.057 ◽

2019 ◽

Vol 28 (3) ◽

pp. 407-414 ◽

Cited By ~ 14

Author(s):

William N. Levine ◽

Julianne Munoz ◽

Stephanie Hsu ◽

Ian R. Byram ◽

Louis U. Bigliani ◽

...

Keyword(s):

Randomized Controlled Trial ◽

Shoulder Arthroplasty ◽

Controlled Trial ◽

Total Shoulder Arthroplasty ◽

Lesser Tuberosity ◽

Randomized Controlled ◽

Primary Osteoarthritis ◽

Prospective Randomized Controlled Trial ◽

Subscapularis Tenotomy

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Mid-term results of anatomical total shoulder arthroplasty for primary osteoarthritis using a short-stemmed cementless humeral component

The Bone & Joint Journal ◽

10.1302/0301-620x.100b5.bjj-2017-1102.r2 ◽

2018 ◽

Vol 100-B (5) ◽

pp. 603-609 ◽

Cited By ~ 22

Author(s):

M. Schnetzke ◽

S. Rick ◽

P. Raiss ◽

G. Walch ◽

M. Loew

Keyword(s):

Cortical Bone ◽

Shoulder Arthroplasty ◽

Total Shoulder Arthroplasty ◽

Bone Adaptation ◽

Filling Ratio ◽

Short Stem ◽

Primary Osteoarthritis ◽

Humeral Component ◽

High Bone

Aims The aim of this study was to evaluate the clinical and radiological outcome of using an anatomical short-stem shoulder prosthesis to treat primary osteoarthritis of the glenohumeral joint. Patients and Methods A total of 66 patients (67 shoulders) with a mean age of 76 years (63 to 92) were available for clinical and radiological follow-up at two different timepoints (T1, mean 2.6 years, sd 0.5; T2, mean 5.3 years, sd 0.7). Postoperative radiographs were analyzed for stem angle, cortical contact, and filling ratio of the stem. Follow-up radiographs were analyzed for timing and location of bone adaptation (cortical bone narrowing, osteopenia, spot welds, and condensation lines). The bone adaptation was classified as low (between zero and three features of bone remodelling around the humeral stem) or high (four or more features). Results The mean Constant score improved significantly from 28.5 (sd 11.6) preoperatively to 75.5 (sd 8.5) at T1 (p < 0.001) and remained stable over time (T2: 76.6, sd 10.2). No stem loosening was seen. High bone adaptation was present in 42% of shoulders at T1, with a slight decrease to 37% at T2. Cortical bone narrowing and osteopenia in the region of the calcar decreased from 76% to 66% between T1 and T2. Patients with high bone adaptation had a significantly higher mean filling ratio of the stem at the metaphysis (0.60, sd 0.05 vs 0.55, sd 0.06; p = 0.003) and at the diaphysis (0.65 sd 0.05 vs 0.60 sd 0.05; p = 0.007). Cortical contact of the stem was also associated with high bone adaptation (14/25 shoulders, p = 0.001). The clinical outcome was not influenced by the radiological changes. Conclusion Total shoulder arthroplasty using a short-stem humeral component resulted in good clinical outcomes with no evidence of loosening. However, approximately 40% of the shoulders developed substantial bone loss in the proximal humerus at between four and seven years of follow-up. Cite this article: Bone Joint J 2018;100-B:603–9.

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