Synthesis of Casein-Related Peptides and Phosphopeptides. XV. The Efficient Synthesis of Multiple-Ser(P)-Containing Peptides

1991 ◽  
Vol 44 (12) ◽  
pp. 1683 ◽  
Author(s):  
JW Perich ◽  
RB Johns
Keyword(s):  
Peptide Synthesis ◽  
Efficient Synthesis

The synthesis of Ac-Ser(P)- NHMe and multiple-Ser(P)-containing peptides Ac-Ser(P)-Ser(P)-NHMe and Ac-Ser(P)-Ser(P)-Ser(P)- NHMe is described. The use of Boc -Ser(PO3Ph2)-OH in the Boc mode of peptide synthesis for the preparation of the protected Ser(PO3Ph2)-containing peptides was followed by platinum-mediated hydrogenolytic deprotection.

Efficient synthesis of glycopeptide-α-thioesters with a high-mannose type oligosaccharide by means of tert-Boc-solid phase peptide synthesis

2012 ◽  
Vol 364 ◽  
pp. 41-48 ◽  
Author(s):  
Yutaka Makimura ◽  
Tatsuto Kiuchi ◽  
Masayuki Izumi ◽  
Simone Dedola ◽  
Yukishige Ito ◽  
...  
Keyword(s):  
Peptide Synthesis ◽  
Solid Phase ◽  
Solid Phase Peptide Synthesis ◽  
Efficient Synthesis ◽  
High Mannose

Efficient Synthesis of N-Methylamino Acids Compatible with Fmoc Solid-Phase Peptide Synthesis

2010 ◽  
pp. 102-103
Author(s):  
Eric Biron ◽  
Jayanta Chatterjee ◽  
Horst Kessler
Keyword(s):  
Peptide Synthesis ◽  
Solid Phase ◽  
Solid Phase Peptide Synthesis ◽  
Efficient Synthesis

A Single Pseudoproline and Microwave Solid Phase Peptide Synthesis Facilitates an Efficient Synthesis of Human Amylin 1–37

2012 ◽  
Vol 19 (2) ◽  
pp. 147-155 ◽  
Author(s):  
Paul W. R. Harris ◽  
Renata Kowalczyk ◽  
Debbie L. Hay ◽  
Margaret A. Brimble
Keyword(s):  
Peptide Synthesis ◽  
Solid Phase ◽  
Solid Phase Peptide Synthesis ◽  
Efficient Synthesis ◽  
Human Amylin

Efficient synthesis of protected l-phosphonophenylalanine (Ppa) derivatives suitable for solid phase peptide synthesis

2007 ◽  
Vol 48 (23) ◽  
pp. 4051-4054 ◽  
Author(s):  
Satendra S. Chauhan ◽  
Arti Varshney ◽  
Bhavana Verma ◽  
Michael W. Pennington
Keyword(s):  
Peptide Synthesis ◽  
Solid Phase ◽  
Solid Phase Peptide Synthesis ◽  
Efficient Synthesis

Synthesis of Casein-Related Peptides and Phosphopeptides. XVI. The Efficient Synthesis of the Casein-Related O-Phosphoseryl-Containing Peptide Ac-Glu-Ser(P)-Leu-Ser(P)-Ser(P)-Ser(P)-Glu-Glu-NHMe

1992 ◽  
Vol 45 (2) ◽  
pp. 385 ◽  
Author(s):  
JW Perich ◽  
RB Johns ◽  
EC Reynolds
Keyword(s):  
Mass Spectrometry ◽  
Amino Acid ◽  
Peptide Synthesis ◽  
Amino Acid Analysis ◽  
Platinum Oxide ◽  
High Yield ◽  
Efficient Synthesis ◽  
Mixed Anhydride ◽  
Coupling Procedure ◽  
One Step

The multiple-O-phosphoseryl-containing peptide, Ac-Glu-Ser (P)-Leu-Ser (P)-Ser (P)-Ser (P)-Glu-Glu-NHMe, was prepared in high yield by the use of Boc-Ser(PO3Ph2)-OH in the Boc mode of peptide synthesis for the preparation of the protected Ser(PO3Ph2)-octapeptide followed by its one-step hydrogenolytic deprotection with platinum oxide. Peptide synthesis was performed by the repetitive excess mixed-anhydride coupling procedure and 40% CF3CO2H/CH2Cl2 for removal of the Boc group from intermediate peptides. The phosphopeptide was found to be greater than 99% pure by C8 r.p.-h.p.1.c. analysis, and was readily characterized by amino acid analysis, 13C n.m.r. spectroscopy and f.a.b. mass spectrometry.

scholarly journals Design of a substrate-tailored peptiligase variant for the efficient synthesis of thymosin-α1

2018 ◽  
Vol 16 (4) ◽  
pp. 609-618 ◽  
Author(s):  
Marcel Schmidt ◽  
Ana Toplak ◽  
Henriëtte J. Rozeboom ◽  
Hein J. Wijma ◽  
Peter J. L. M. Quaedflieg ◽  
...  
Keyword(s):  
Peptide Synthesis ◽  
Efficient Synthesis ◽  
Enzymatic Peptide Synthesis ◽  
Thymosin Α1

A substrate-tailored peptide ligase for the chemo-enzymatic peptide synthesis (CEPS) of thymosin-α1.

scholarly journals Efficient Synthesis of Peptides with 4-Methylpiperidine as Fmoc Removal Reagent by Solid Phase Synthesis

2017 ◽  
Vol 58 (4) ◽  
Author(s):  
Javier Eduardo García Castañeda ◽  
Cristian Francisco Vergel Galeano ◽  
Zuly Jenny Rivera Monroy ◽  
Javier Eduardo Rosas Pérez
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Peptide Synthesis ◽  
Synthetic Peptides ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Solid Phase Peptide Synthesis ◽  
Amino Group ◽  
Efficient Synthesis ◽  
Phase Synthesis

<p>Solid phase peptide synthesis using the Fmoc/<em>t</em>-Bu strategy (SPPS-Fmoc/tBu) is the most widely used methodology for obtaining synthetic peptides. In this paper, we evaluate the viability of using 4-methylpiperidine as a reagent for deprotection of the amino acid alpha amino group in SPPS-Fmoc/tBu. For this purpose, the peptide (RRWQWRMKKLG) was simultaneously synthesized using 4-methylpiperidine or piperidine for Fmoc removal reagent. The obtained products had similar purities and yields. Finally, 21 peptides were synthesized using 4-methylpiperidine. Our results suggest that is possible to obtain synthetic peptides efficiently by the strategy SPPS-Fmoc/tBu when 4-methylpiperidine was used as reagent to remove Fmoc groups N-alpha protected amino acids.</p>

scholarly journals Green Solvent Mixtures for Solid-Phase Peptide Synthesis: A Dimethylformamide-Free Highly Efficient Synthesis of Pharmaceutical-Grade Peptides

2019 ◽  
Vol 7 (15) ◽  
pp. 12867-12877 ◽  
Author(s):  
Lucia Ferrazzano ◽  
Dario Corbisiero ◽  
Giulia Martelli ◽  
Alessandra Tolomelli ◽  
Angelo Viola ◽  
...  
Keyword(s):  
Peptide Synthesis ◽  
Solid Phase ◽  
Solid Phase Peptide Synthesis ◽  
Solvent Mixtures ◽  
Green Solvent ◽  
Efficient Synthesis ◽  
Highly Efficient

An efficient synthesis of 2-hydroxy-gibberellins

1986 ◽  
Vol 29 (9) ◽  
pp. 1109-1112
Author(s):  
M Beale
Keyword(s):  
Efficient Synthesis

A new facile and efficient synthesis of trans-(+)-sobrerol by biotransformation of α-pinene using extremophiles microorganisms

Planta Medica ◽  
2009 ◽  
Vol 75 (09) ◽  
Author(s):  
LA Vilaseca ◽  
J Quillaguamán ◽  
L Fuentes ◽  
O Sterner
Keyword(s):  
Efficient Synthesis
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