Genital herpes vaccines—cause for cautious optimism

Sexual Health ◽  
2006 ◽  
Vol 3 (1) ◽  
pp. 1 ◽  
Author(s):  
Lewis J. Haddow ◽  
Adrian Mindel
Keyword(s):  
Clinical Trials ◽  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Genital Herpes ◽  
Clinical Results ◽  
Virus Infections ◽  
High Prevalence ◽  
Males And Females ◽  
The Difference ◽  
Simplex Virus

The high prevalence of herpes simplex virus infections in many communities, its numerous serious physical and psychological complications and its importance in enhancing the transmission of HIV make this virus an obvious target for prevention by vaccination. Randomised clinical trials of only one genital herpes vaccine has shown efficacy so far. Analysis of clinical results is complicated by the difference between disease and infection, different results for males and females and the interaction between HSV-1 and HSV-2 immunity.

Essential Oils for the Treatment of Herpes Simplex Virus Infections

Chemotherapy ◽  
2019 ◽  
Vol 64 (1) ◽  
pp. 1-7 ◽  
Author(s):  
Paul Schnitzler
Keyword(s):  
Clinical Trials ◽  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Essential Oils ◽  
Full Potential ◽  
Virus Infections ◽  
Synthetic Drugs ◽  
Cell Adsorption ◽  
Simplex Virus ◽  
Hsv 1

Infections with herpes simplex virus type (HSV)-1 and HSV-2 are distributed worldwide. Although standard therapies with acyclovir and other synthetic drugs are available, the safety and efficacy of these drugs are limited due to the development of drug resistance and adverse side effects. The literature on essential oils and isolated compounds was reviewed regarding their antiviral activities against HSV-1 and HSV-2. The present overview aims to review experimental data and clinical trials focusing on the antiviral activity of selected essential oils and isolated oil components. HSV was found to be susceptible to many essential oils and their constituents. Whereas some essential oils and compounds exhibit direct virucidal activity or inhibit intracellular replication, many essential oils and compounds interact with HSV particles thereby inhibiting cell adsorption. Ayclovir-resistant HSV strains are also susceptible to essential oils since their mode of action is different from the synthetic drug. There are numerous publications on the antiherpetic activity of essential oils and their isolated active compounds. This field of research is still growing, and more clinical trials are required to explore the full potential of different essential oils for the topical treatment of herpetic infections.

scholarly journals Herpes Simplex Virus Type 1 is the Leading Cause of Genital Herpes in New Brunswick

2012 ◽  
Vol 23 (1) ◽  
pp. 15-18 ◽  
Author(s):  
Richard Garceau ◽  
Danielle Leblanc ◽  
Louise Thibault ◽  
Gabriel Girouard ◽  
Manon Mallet
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
New Brunswick ◽  
Genital Herpes ◽  
Age Group ◽  
Dominant Type ◽  
Viral Culture ◽  
The Difference ◽  
Simplex Virus

INTRODUCTION: Little is known about the role of herpes simplex virus (HSV) type 1 (HSV1) in the epidemiology of genital herpes in Canada. Data on herpes viral cultures for two consecutive years obtained from L’Hôpital Dr GL Dumont, which performs all the viral culture testing in New Brunswick, were reviewed. It was hypothesized that HSV1 was the main cause of genital herpes in New Brunswick.METHODS: Samples of genital origin sent to the laboratory for HSV culture testing between July 2006 and June 2008 were analyzed. Samples from an unspecified or a nongenital source were excluded from analysis. Multiple positive samples collected from the same patient were pooled into a single sample.RESULTS: HSV was isolated from 764 different patients. HSV1 was isolated in 62.6% of patients (male, 55%; female, 63.8%). HSV1 was isolated in 73.2% of patients 10 to 39 years of age and in 32% of patients ≥40 years of age. The difference in rates of HSV1 infection between the 10 to 39 years of age group and the ≥40 years of age group was statistically significant (P<0.001 [χ2]). In a similar Canadian study performed in Nova Scotia, HSV1 was recovered in 53.7% of positive cultures (male, 36.7%; female, 58.1%). The rates of HSV1 infection reported by this study and the present study were significantly different (P<0.001 [χ2] for male, P=0.012 for female).CONCLUSION: In New Brunswick, HSV1 is the dominant type of HSV isolated in samples collected from a genital site. Significant rate differences were demonstrated between the groups 10 to 39 years of age and ≥40 years of age.

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