scholarly journals The laterodorsal tegmentum is essential for burst firing of ventral tegmental area dopamine neurons

2006 ◽  
Vol 103 (13) ◽  
pp. 5167-5172 ◽  
Author(s):  
D. J. Lodge ◽  
A. A. Grace
Keyword(s):  
Ventral Tegmental Area ◽  
Burst Firing ◽  
Dopamine Neurons ◽  
Ventral Tegmental ◽  
Laterodorsal Tegmentum

Nitric oxide is involved in nicotine-induced burst firing of rat ventral tegmental area dopamine neurons

Neuroscience ◽  
2004 ◽  
Vol 125 (4) ◽  
pp. 957-964 ◽  
Author(s):  
B Schilström ◽  
M Mameli-Engvall ◽  
N Rawal ◽  
P Grillner ◽  
K Jardemark ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Ventral Tegmental Area ◽  
Burst Firing ◽  
Dopamine Neurons ◽  
Ventral Tegmental

scholarly journals The laterodorsal tegmentum-ventral tegmental area circuit controls depression-like behaviors by activating ErbB4 in DA neurons

2021 ◽  
Author(s):  
Hongsheng Wang ◽  
Wanpeng Cui ◽  
Wenbing Chen ◽  
Fang Liu ◽  
Zhaoqi Dong ◽  
...  
Keyword(s):  
Ventral Tegmental Area ◽  
Molecular Mechanisms ◽  
Critical Role ◽  
Coping With Stress ◽  
Chemical Genetic ◽  
Chronic Social Defeat Stress ◽  
Ventral Tegmental ◽  
Laterodorsal Tegmentum ◽  
Specific Deletion

AbstractDopamine (DA) neurons in the ventral tegmental area (VTA) are critical to coping with stress. However, molecular mechanisms regulating their activity and stress-induced depression were not well understood. We found that the receptor tyrosine kinase ErbB4 in VTA was activated in stress-susceptible mice. Deleting ErbB4 in VTA or in DA neurons, or chemical genetic inhibition of ErbB4 kinase activity in VTA suppressed the development of chronic social defeat stress (CSDS)-induced depression-like behaviors. ErbB4 activation required the expression of NRG1 in the laterodorsal tegmentum (LDTg); LDTg-specific deletion of NRG1 inhibited depression-like behaviors. NRG1 and ErbB4 suppressed potassium currents of VTA DA neurons and increased their firing activity. Finally, we showed that acute inhibition of ErbB4 after stress attenuated DA neuron hyperactivity and expression of depression-like behaviors. Together, these observations demonstrate a critical role of NRG1-ErbB4 signaling in regulating depression-like behaviors and identify an unexpected mechanism by which the LDTg-VTA circuit regulates the activity of DA neurons.

scholarly journals GABA Site Agonist Gaboxadol Induces Addiction-Predicting Persistent Changes in Ventral Tegmental Area Dopamine Neurons But Is Not Rewarding in Mice or Baboons

2012 ◽  
Vol 32 (15) ◽  
pp. 5310-5320 ◽  
Author(s):  
E. Vashchinkina ◽  
A. Panhelainen ◽  
O. Y. Vekovischeva ◽  
T. Aitta-aho ◽  
B. Ebert ◽  
...  
Keyword(s):  
Ventral Tegmental Area ◽  
Dopamine Neurons ◽  
Ventral Tegmental

The Evolving Understanding of Dopamine Neurons in the Substantia Nigra and Ventral Tegmental Area

2018 ◽  
Vol 80 (1) ◽  
pp. 219-241 ◽  
Author(s):  
Stephanie C. Gantz ◽  
Christopher P. Ford ◽  
Hitoshi Morikawa ◽  
John T. Williams
Keyword(s):  
Substantia Nigra ◽  
Ventral Tegmental Area ◽  
Dopamine Neurons ◽  
Ventral Tegmental

scholarly journals Sensitization of Ventral Tegmental Area Dopamine Neurons to the Stimulating Effects of Ethanol

2009 ◽  
Vol 33 (9) ◽  
pp. 1571-1581 ◽  
Author(s):  
Zheng-Ming Ding ◽  
Zachary A. Rodd ◽  
Eric A. Engleman ◽  
William J. McBride
Keyword(s):  
Ventral Tegmental Area ◽  
Dopamine Neurons ◽  
Ventral Tegmental
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