Structure-based ligand discovery for the Large-neutral Amino Acid Transporter 1, LAT-1

Proceedings of the National Academy of Sciences ◽

10.1073/pnas.1218165110 ◽

2013 ◽

Vol 110 (14) ◽

pp. 5480-5485 ◽

Author(s):

E. G. Geier ◽

A. Schlessinger ◽

H. Fan ◽

J. E. Gable ◽

J. J. Irwin ◽

...

Keyword(s):

Amino Acid Transporter ◽

Neutral Amino Acid ◽

Large Neutral Amino Acid ◽

Neutral Amino Acid Transporter ◽

Ligand Discovery ◽

Acid Transporter

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Insights into the Structure, Function, and Ligand Discovery of the Large Neutral Amino Acid Transporter 1, LAT1

International Journal of Molecular Sciences ◽

10.3390/ijms19051278 ◽

2018 ◽

Vol 19 (5) ◽

pp. 1278 ◽

Author(s):

Natesh Singh ◽

Gerhard Ecker

Keyword(s):

Structure Function ◽

Amino Acid Transporter ◽

Neutral Amino Acid ◽

Large Neutral Amino Acid ◽

Neutral Amino Acid Transporter ◽

Ligand Discovery ◽

Acid Transporter

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Regulation of Mammalian Large Neutral Amino Acid Transporter LAT1 by its Partner CD98

Biophysical Journal ◽

10.1016/j.bpj.2017.11.1848 ◽

2018 ◽

Vol 114 (3) ◽

pp. 329a-330a

Author(s):

Qingnan Liang ◽

Pattama Wiriyasermkul ◽

Matthias Quick ◽

Ming Zhou

Keyword(s):

Amino Acid Transporter ◽

Neutral Amino Acid ◽

Large Neutral Amino Acid ◽

Neutral Amino Acid Transporter ◽

Acid Transporter

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Abstract 4543: Uptake of18F-FDOPA analogue3H-L-DOPA is mediated by large neutral amino acid transporter LAT1 in human glioblastoma

10.1158/1538-7445.am2012-4543 ◽

2012 ◽

Author(s):

Ryan S. Youland ◽

Gaspar J. Kitange ◽

Jenny L. Pokorny ◽

Jann N. Sarkaria

Keyword(s):

Amino Acid Transporter ◽

Neutral Amino Acid ◽

Large Neutral Amino Acid ◽

Human Glioblastoma ◽

Neutral Amino Acid Transporter ◽

Acid Transporter

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Identification and functional characterization of a Na+-independent large neutral amino acid transporter (LAT2) on ARPE-19 cells

International Journal of Pharmaceutics ◽

10.1016/j.ijpharm.2004.01.035 ◽

2004 ◽

Vol 275 (1-2) ◽

pp. 189-200 ◽

Author(s):

Mohit D. Gandhi ◽

Dhananjay Pal ◽

Ashim K. Mitra

Keyword(s):

Functional Characterization ◽

Amino Acid Transporter ◽

Neutral Amino Acid ◽

Large Neutral Amino Acid ◽

Neutral Amino Acid Transporter ◽

Acid Transporter

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Functional activity of a large neutral amino acid transporter (LAT) in rabbit retina: A study involving the in vivo retinal uptake and vitreal pharmacokinetics of l-phenyl alanine

International Journal of Pharmaceutics ◽

10.1016/j.ijpharm.2007.06.038 ◽

2008 ◽

Vol 347 (1-2) ◽

pp. 23-30 ◽

Author(s):

Harisha Atluri ◽

Ravi S. Talluri ◽

Ashim K. Mitra

Keyword(s):

Functional Activity ◽

Amino Acid Transporter ◽

Neutral Amino Acid ◽

Large Neutral Amino Acid ◽

Rabbit Retina ◽

Neutral Amino Acid Transporter ◽

Acid Transporter ◽

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Large Neutral Amino Acid Transporter Enables Brain Drug Delivery via Prodrugs

Journal of Medicinal Chemistry ◽

10.1021/jm701175d ◽

2008 ◽

Vol 51 (4) ◽

pp. 932-936 ◽

Author(s):

Mikko Gynther ◽

Krista Laine ◽

Jarmo Ropponen ◽

Jukka Leppänen ◽

Anne Mannila ◽

...

Keyword(s):

Drug Delivery ◽

Amino Acid Transporter ◽

Neutral Amino Acid ◽

Large Neutral Amino Acid ◽

Brain Drug Delivery ◽

Neutral Amino Acid Transporter ◽

Acid Transporter

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Predominant functional activity of the large, neutral amino acid transporter (LAT1) isoform at the cerebrovasculature

Neuroscience Letters ◽

10.1016/s0304-3940(01)01810-9 ◽

2001 ◽

Vol 306 (1-2) ◽

pp. 1-4 ◽

Author(s):

Dennis M. Killian ◽

Prashant J. Chikhale

Keyword(s):

Functional Activity ◽

Amino Acid Transporter ◽

Neutral Amino Acid ◽

Large Neutral Amino Acid ◽

Neutral Amino Acid Transporter ◽

Acid Transporter

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Regiospecific and conformationally restrained analogs of melphalan and dl-2-NAM-7 and their affinities for the large neutral amino acid transporter (system LAT1) of the blood–brain barrier

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2010.04.086 ◽

2010 ◽

Vol 20 (12) ◽

pp. 3688-3691 ◽

Author(s):

Jyothi Matharu ◽

Jun Oki ◽

David R. Worthen ◽

Quentin R. Smith ◽

Peter A. Crooks

Keyword(s):

Blood Brain Barrier ◽

Amino Acid Transporter ◽

Neutral Amino Acid ◽

Brain Barrier ◽

Large Neutral Amino Acid ◽

Neutral Amino Acid Transporter ◽

Blood Brain ◽

Acid Transporter ◽

Conformationally Restrained

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The methylmercury-l-cysteine conjugate is a substrate for the L-type large neutral amino acid transporter

Journal of Neurochemistry ◽

10.1111/j.1471-4159.2008.05683.x ◽

2008 ◽

Author(s):

Zhaobao Yin ◽

Haiyan Jiang ◽

Tore Syversen ◽

João B. T. Rocha ◽

Marcelo Farina ◽

...

Keyword(s):

Amino Acid Transporter ◽

Neutral Amino Acid ◽

Large Neutral Amino Acid ◽

Neutral Amino Acid Transporter ◽

Acid Transporter

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Targeting the Cerebrovascular Large Neutral Amino Acid Transporter (LAT1) Isoform Using a Novel Disulfide-Based Brain Drug Delivery System

Drug Delivery ◽

10.1080/10717540600559510 ◽

2007 ◽

Vol 14 (1) ◽

pp. 25-31 ◽

Author(s):

Dennis M. Killian ◽

Suzanne Hermeling ◽

Prashant J. Chikhale

Keyword(s):

Drug Delivery ◽

Drug Delivery System ◽

Delivery System ◽

Amino Acid Transporter ◽

Neutral Amino Acid ◽

Large Neutral Amino Acid ◽

Brain Drug Delivery ◽

Neutral Amino Acid Transporter ◽

Acid Transporter

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