scholarly journals Pinpointing the neural signatures of single-exposure visual recognition memory

2021 ◽  
Vol 118 (18) ◽  
pp. e2021660118
Author(s):  
Vahid Mehrpour ◽  
Travis Meyer ◽  
Eero P. Simoncelli ◽  
Nicole C. Rust
Keyword(s):  
Recognition Memory ◽  
Visual Recognition ◽  
Neural Responses ◽  
Single Exposure ◽  
Stimulus Attribute ◽  
Repetition Suppression ◽  
Visual Recognition Memory ◽  
Visual Areas ◽  
High Level ◽  
Lower Contrast

Memories of the images that we have seen are thought to be reflected in the reduction of neural responses in high-level visual areas such as inferotemporal (IT) cortex, a phenomenon known as repetition suppression (RS). We challenged this hypothesis with a task that required rhesus monkeys to report whether images were novel or repeated while ignoring variations in contrast, a stimulus attribute that is also known to modulate the overall IT response. The monkeys’ behavior was largely contrast invariant, contrary to the predictions of an RS-inspired decoder, which could not distinguish responses to images that are repeated from those that are of lower contrast. However, the monkeys’ behavioral patterns were well predicted by a linearly decodable variant in which the total spike count was corrected for contrast modulation. These results suggest that the IT neural activity pattern that best aligns with single-exposure visual recognition memory behavior is not RS but rather sensory referenced suppression: reductions in IT population response magnitude, corrected for sensory modulation.

scholarly journals Pinpointing the neural signatures of single-exposure visual familiarity

2020 ◽  
Author(s):  
Vahid Mehrpour ◽  
Travis Meyer ◽  
Eero P. Simoncelli ◽  
Nicole C. Rust
Keyword(s):  
Neural Activity ◽  
Rhesus Monkeys ◽  
Sensory Modulation ◽  
Neural Responses ◽  
Single Exposure ◽  
Encoding Scheme ◽  
Stimulus Attribute ◽  
Repetition Suppression ◽  
Visual Areas ◽  
High Level

AbstractMemories of the images that we have seen are thought to be reflected in the reduction of neural responses in high-level visual areas such as inferotemporal (IT) cortex, a phenomenon known as repetition suppression (RS). We challenged this hypothesis with a task that required rhesus monkeys to report image familiarity while ignoring variations in contrast, a stimulus attribute that is also known to modulate the overall IT response. The monkeys’ behavior was largely contrast-invariant, contrary to the predictions of the RS encoding scheme, which could not distinguish response familiarity from changes in contrast. However, the monkeys’ behavioral patterns were well predicted by a linearly decodable variant in which the total spike count is corrected for contrast modulation. These results suggest that the IT neural activity pattern that best aligns with single-exposure visual familiarity behavior is not RS but rather “sensory referenced suppression (SRS)”: reductions in IT population response magnitude, corrected for sensory modulation.

scholarly journals Temporal tuning of repetition suppression across the visual cortex

2020 ◽  
Vol 123 (1) ◽  
pp. 224-233 ◽  
Author(s):  
Matthias Fritsche ◽  
Samuel J. D. Lawrence ◽  
Floris P. de Lange
Keyword(s):  
Visual System ◽  
Blood Oxygen Level Dependent ◽  
Similar Rate ◽  
Visual Input ◽  
Neural Responses ◽  
Repetition Suppression ◽  
Visual Hierarchy ◽  
Visual Areas ◽  
High Level ◽  
Posterior Anterior

The visual system adapts to its recent history. A phenomenon related to this is repetition suppression (RS), a reduction in neural responses to repeated compared with nonrepeated visual input. An intriguing hypothesis is that the timescale over which RS occurs across the visual hierarchy is tuned to the temporal statistics of visual input features, which change rapidly in low-level areas but are more stable in higher level areas. Here, we tested this hypothesis by studying the influence of the temporal lag between successive visual stimuli on RS throughout the visual system using functional (f)MRI. Twelve human volunteers engaged in four fMRI sessions in which we characterized the blood oxygen level-dependent response to pairs of repeated and nonrepeated natural images with interstimulus intervals (ISI) ranging from 50 to 1,000 ms to quantify the temporal tuning of RS along the posterior-anterior axis of the visual system. As expected, RS was maximal for short ISIs and decayed with increasing ISI. Crucially, however, and against our hypothesis, RS decayed at a similar rate in early and late visual areas. This finding challenges the prevailing view that the timescale of RS increases along the posterior-anterior axis of the visual system and suggests that RS is not tuned to temporal input regularities. NEW & NOTEWORTHY Visual areas show reduced neural responses to repeated compared with nonrepeated visual input, a phenomenon termed repetition suppression (RS). Here we show that RS decays at a similar rate in low- and high-level visual areas, suggesting that the short-term decay of RS across the visual hierarchy is not tuned to temporal input regularities. This may limit the specificity with which the mechanisms underlying RS could optimize the processing of input features across the visual hierarchy.

Neurotoxic lesions of perirhinal cortex impair visual recognition memory in rhesus monkeys

Neuroreport ◽  
2001 ◽  
Vol 12 (9) ◽  
pp. 1913-1917 ◽  
Author(s):  
Ludisue M??lkov?? ◽  
Jocelyne Bachevalier ◽  
Mortimer Mishkin ◽  
Richard C. Saunders
Keyword(s):  
Recognition Memory ◽  
Rhesus Monkeys ◽  
Visual Recognition ◽  
Perirhinal Cortex ◽  
Visual Recognition Memory ◽  
Neurotoxic Lesions

Visual recognition memory and developmental outcomes of cocaine-exposed and non-exposed infants

1998 ◽  
Vol 21 ◽  
pp. 687
Author(s):  
Lynn T. Singer ◽  
Robert Arendt ◽  
Sonia Minnes ◽  
Ann Salvator ◽  
Joanne Robinson ◽  
...  
Keyword(s):  
Recognition Memory ◽  
Visual Recognition ◽  
Developmental Outcomes ◽  
Visual Recognition Memory

Mnemonic firing of neurons in the monkey temporal pole during a visual recognition memory task

1995 ◽  
Vol 74 (1) ◽  
pp. 162-178 ◽  
Author(s):  
K. Nakamura ◽  
K. Kubota
Keyword(s):  
Recognition Memory ◽  
Visual Information ◽  
Visual Recognition ◽  
Discharge Rate ◽  
Memory Task ◽  
Delay Period ◽  
Recognition Memory Task ◽  
Visual Response ◽  
Visual Recognition Memory ◽  
Temporal Pole

1. We examined single-neuronal activity in the temporal pole of monkeys, including the anterior ventromedial temporal (VMT) cortex (the temporopolar cortex, area 36, area 35, and the entorhinal cortex) and the anterior inferotemporal (IT) cortex, during a visual recognition memory task. In the task, a trial began when the monkey pressed a lever. After a waiting period, a visual sample stimulus (S) was presented one to four times on a monitor with an interstimulus delay. Thereafter, a new stimulus (R) was presented. The monkeys were trained to remember S during the delay period and to release the lever in response to R. Colored photographs of natural objects were used as visual stimuli. 2. About 70% of the recorded neurons (225 of 311) responded to at least one of the Ss tested. Thirty percent of these neurons (68 of 225) continued to fire during the subsequent delay periods. In 75% of these neurons (51 of 68), the firing during the delay period strongly correlated with the response to S. 3. The discharge rate during the delay period did not correlate with the monkey's eye movements, pressing or releasing of the lever, or the reaction time. 4. If the monkey erroneously released the lever in response to S or during the delay period, the firing disappeared after the erroneous lever release. If the monkey failed to release the lever in response to R, the firing persisted even after R was withdrawn. The discharge rate in incorrect trials was comparable with that in correct trials. The neurons were considered to fire for as long as the memory of S was necessary. 5. Firing persisted even when an achromatic version or half (even a portion) of S was presented, indicating that the color, a particular portion, or the entire shape of S was not always necessary to elicit firing. 6. An S that elicited firing during the delay period invariably elicited a visual response. Neurons that fired during the delay period showed a higher stimulus selectivity than other visually responsive neurons in the anterior VMT cortex. Thus neurons that fire during the delay period represent a subgroup of visually responsive neurons that are selectively tuned to a certain stimulus. 7. More neurons fired during the delay period in the anterior VMT cortex than in the anterior IT cortex. 8. We conclude that firing during the delay period by neurons in the temporal pole reflects the short-term storage of visual information regarding a particular S.

Neurocognitive deficits in decision-making and planning of patients with DSM-III-R borderline personality disorder

2002 ◽  
Vol 32 (8) ◽  
pp. 1395-1405 ◽  
Author(s):  
E. BAZANIS ◽  
R. D. ROGERS ◽  
J. H. DOWSON ◽  
P. TAYLOR ◽  
C. MEUX ◽  
...  
Keyword(s):  
Decision Making ◽  
Borderline Personality Disorder ◽  
Personality Disorder ◽  
Recognition Memory ◽  
Frontal Lobe ◽  
Visual Recognition ◽  
Borderline Personality ◽  
Neurocognitive Deficits ◽  
Visual Recognition Memory ◽  
History Of

Background. Repeated, self-damaging behaviour occurring in the context of borderline personality disorder (BPD) may reflect impairments in decision-making and planning cognition. However, there has been no systematic neuropsychological examination of these particular cognitive functions in patients diagnosed with BPD. Such investigations may improve our understanding of the possible role of brain dysfunction in BPD and improve the characterization of the psychological difficulties associated with this disorder.Method. Forty-two psychiatric patients with a diagnosis of DSM-III-R BPD (41 of whom gave a history of self-harm), without a history of specified ‘psychoses’ or current major affective disorder, were clinically assessed before completing computerized tasks of decision-making and planning previously shown to be sensitive to frontal lobe dysfunction, and tests of spatial and pattern visual recognition memory previously shown to be sensitive to frontal lobe damage and temporal lobe damage respectively. The performance of the BPD patient group was compared with that of a non-clinical control group consisting of 42 subjects.Results. The performance of the BPD patients on the decision-making task was characterized by a pattern of delayed and maladaptive choices when choosing between competing actions, and by impulsive, disinhibited responding when gambling on the outcome of their decisions. BPD patients also showed impairments on the planning task. There was no evidence of impaired visual recognition memory. Additional analyses suggested only limited effects of current medication and history of previous substance use disorder.Conclusions. These findings suggest that BPD is associated with complex impairments in dissociable cognitive processes mediated by circuitry encompassing the frontal lobes. These impairments may mediate some of the behavioural changes evident in BPD. Further work is needed to examine the specificity of these findings.

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