scholarly journals Alpha-fetoprotein, the major fetal serum protein, is not essential for embryonic development but is required for female fertility

2002 ◽  
Vol 99 (20) ◽  
pp. 12865-12870 ◽  
Author(s):  
P. Gabant ◽  
L. Forrester ◽  
J. Nichols ◽  
T. Van Reeth ◽  
C. De Mees ◽  
...  
1984 ◽  
Vol 32 (2) ◽  
pp. 708-715 ◽  
Author(s):  
KAZUYUKI HIRANO ◽  
YOSHIHITO WATANABE ◽  
TETSUO ADACHI ◽  
MAMORU SUGIURA

2009 ◽  
Vol 35 (2) ◽  
pp. 271-276 ◽  
Author(s):  
Fernando González-Bugatto ◽  
Esther Foncubierta ◽  
María de los Ángeles Bailén ◽  
Sebastián Illanes ◽  
Blas Hervías-Vivancos ◽  
...  

1978 ◽  
Vol 235 (1) ◽  
pp. E27 ◽  
Author(s):  
P C Lai ◽  
G J Mears ◽  
G R van Petten ◽  
D M Hay ◽  
F L Lorscheider

The concentration of ovine alpha-fetoprotein (AFP) was determined in sheep fetal, maternal, and neonatal sera and amniotic fluid by radioimmunoassay. The fetal serum AFP concentration was highest during the first third of pregnancy and continued to decline with fetal and neonatal development. Total fetal synthesis of AFP was highest during the late middle and early latter third of pregnancy. Amniotic fluid AFP concentration was highest during the early middle third of pregnancy. Maternal serum AFP was not elevated above nonpregnant control levels during the first two-thirds of pregnancy, but instead showed a tendency to be elevated only during the last third of pregnancy. The fetal physiological distributions of ovine and human AFP in fetal serum and amniotic fluid appear to be similar, whereas in maternal serum the pattern of AFP levels differs in the two species as a function of gestational age.


1991 ◽  
Vol 11 (8) ◽  
pp. 625-628 ◽  
Author(s):  
J. M. M. van Lith ◽  
J. R. Beekhuis ◽  
A. J. van Loon ◽  
A. Mantingh ◽  
B. T. H. M. de Wolf ◽  
...  

1991 ◽  
Vol 39 (12) ◽  
pp. 1679-1684 ◽  
Author(s):  
L Sanchez Palazon ◽  
A Rodriguez-Burgos

Alpha-fetoprotein (AFP) is a major globulin of the embryonic serum of mammals, birds, and other vertebrates. It is synthesized chiefly by the liver and/or the yolk sac. The aim of this work was to confirm the occurrence of AFP in the chorioallantoic membrane (CAM) from 14-day chick embryo. AFP had previously been detected by immunoelectrophoresis in CAM extracts under the suspicion that it could be a mere artifact resulting from blood contamination. The immunohistochemical study of the CAM carried out for this purpose revealed the protein to be solely located in the mesodermal layer. The joint use of organ culture and immunoperoxidase techniques has enabled us to find evidence for the synthesis of AFP in the cells of this layer. These results confirm the occurrence of such a significant carrier globulin to embryonic development in one more tissue that can be added to the short list of AFP-producing tissues.


2003 ◽  
Vol 23 (11) ◽  
pp. 917-920 ◽  
Author(s):  
Jose L. Bartha ◽  
Gayle Harrison ◽  
Phillipa M. Kyle ◽  
Peter W. Soothill

1977 ◽  
Vol 148 (4) ◽  
pp. 457-462 ◽  
Author(s):  
Christopher C. K. Leung ◽  
Hiroyuki Watabe ◽  
Robert L. Brent

2008 ◽  
Vol 128 (3) ◽  
pp. 753-757 ◽  
Author(s):  
Xue-Qing Wang ◽  
Mark T. Hayes ◽  
Margit Kempf ◽  
John F. Fraser ◽  
Pei-Yun Liu ◽  
...  

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