scholarly journals Fetuin-A: A Major Fetal Serum Protein that Promotes “Wound Closure” and Scarless Healing

2008 ◽  
Vol 128 (3) ◽  
pp. 753-757 ◽  
Author(s):  
Xue-Qing Wang ◽  
Mark T. Hayes ◽  
Margit Kempf ◽  
John F. Fraser ◽  
Pei-Yun Liu ◽  
...  
Keyword(s):  
Serum Protein ◽  
Wound Closure ◽  
Fetuin A ◽  
Fetal Serum ◽  
Scarless Healing

Fetuin A: a new neuroprotective serum protein?

2012 ◽  
Vol 43 (02) ◽  
Author(s):  
M Häusler ◽  
J Elsas ◽  
B Sellhaus ◽  
A Kinkeldey ◽  
M Herrmann ◽  
...  
Keyword(s):  
Serum Protein ◽  
Fetuin A

scholarly journals CCAAT enhancer binding protein β and hepatocyte nuclear factor 3β are necessary and sufficient to mediate dexamethasone-induced up-regulation of alpha2HS-glycoprotein/fetuin-A gene expression

2006 ◽  
Vol 36 (2) ◽  
pp. 261-277 ◽  
Author(s):  
Michael Wöltje ◽  
Beate Tschöke ◽  
Verena von Bülow ◽  
Ralf Westenfeld ◽  
Bernd Denecke ◽  
...  
Keyword(s):  
Serum Protein ◽  
Binding Protein ◽  
Protein A ◽  
Nuclear Factor ◽  
Hepatocyte Nuclear Factor ◽  
Tissue Remodelling ◽  
Mobility Shift ◽  
Fetuin A ◽  
Enhancer Binding Protein ◽  
Ccaat Enhancer Binding Protein

Alpha2HS-glycoprotein/fetuin-A (Ahsg) is a serum protein preventing soft tissue calcification. In trauma and inflammation, Ahsg is down-regulated and therefore considered a negative acute phase protein. Enhancement of Ahsg expression as a protective serum protein is desirable in several diseases including tissue remodelling after trauma and infection, kidney and heart failure, and cancer. Using reporter gene assays in hepatoma cells combined with electrophoretic mobility shift assays we determined that dexamethasone up-regulates hepatic Ahsg. A steroid response unit at position −146/−119 within the mouse Ahsg promoter mediates the glucocorticoid-induced increase of Ahsg mRNA. It binds the hepatocyte nuclear factor 3β and CCAAT enhancer binding protein β (C/EBP-β). The up-regulation is mediated indirectly via glucocorticoid hormone-induced transcriptional up-regulation in C/EBP-β protein. A high degree of sequence identity in mouse, rat and human Ahsg promoters suggests that the promoter is similarly up-regulated by dexamethasone in all three species. Therefore, our findings suggest that glucocorticoids may be used to enhance the level of Ahsg protein circulating in serum.

scholarly journals Studies on Fetuin, a Glycoprotein of Fetal Serum

1962 ◽  
Vol 237 (2) ◽  
pp. 382-388 ◽  
Author(s):  
Robert G. Spiro
Keyword(s):  
Fetuin A ◽  
Fetal Serum

scholarly journals Alpha-fetoprotein, the major fetal serum protein, is not essential for embryonic development but is required for female fertility

2002 ◽  
Vol 99 (20) ◽  
pp. 12865-12870 ◽  
Author(s):  
P. Gabant ◽  
L. Forrester ◽  
J. Nichols ◽  
T. Van Reeth ◽  
C. De Mees ◽  
...  
Keyword(s):  
Embryonic Development ◽  
Serum Protein ◽  
Alpha Fetoprotein ◽  
Female Fertility ◽  
Fetal Serum

scholarly journals The serum protein α2–Heremans-Schmid glycoprotein/fetuin-A is a systemically acting inhibitor of ectopic calcification

2003 ◽  
Vol 112 (3) ◽  
pp. 357-366 ◽  
Author(s):  
Cora Schäfer ◽  
Alexander Heiss ◽  
Anke Schwarz ◽  
Ralf Westenfeld ◽  
Markus Ketteler ◽  
...  
Keyword(s):  
Serum Protein ◽  
Ectopic Calcification ◽  
Fetuin A

FETUIN, A UBIQUITOUS SERUM PROTEIN, INHIBITS EDEMA FORMATION AND TNF

Shock ◽  
1999 ◽  
Vol 11 (Supplement) ◽  
pp. 39
Author(s):  
M. Ombrellino ◽  
H. Wang ◽  
J. Che ◽  
J. Vishnubhakat ◽  
L. Borovikova ◽  
...  
Keyword(s):  
Serum Protein ◽  
Edema Formation ◽  
Fetuin A

scholarly journals Variation of fetuin-A in maternal and fetal serum during human parturition

2019 ◽  
Vol 48 (7) ◽  
pp. 515-519
Author(s):  
Miguel Albuquerque ◽  
Dominique Luton ◽  
Julie Le Faouder ◽  
Pierre Bedossa ◽  
Jean Guibourdenche ◽  
...  
Keyword(s):  
Fetuin A ◽  
Fetal Serum ◽  
Human Parturition

scholarly journals Multifunctional Roles for Serum Protein Fetuin-A in Inhibition of Human Vascular Smooth Muscle Cell Calcification

2005 ◽  
Vol 16 (10) ◽  
pp. 2920-2930 ◽  
Author(s):  
Joanne L. Reynolds ◽  
Jeremy N. Skepper ◽  
Rosamund McNair ◽  
Takeshi Kasama ◽  
Kunal Gupta ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Serum Protein ◽  
Muscle Cell ◽  
Vascular Smooth Muscle Cell ◽  
Fetuin A
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