scholarly journals Membrane difference in peripheral blood lymphocytes from patients with chronic lymphocytic leukemia and Hodgkin's disease.

1975 ◽  
Vol 72 (6) ◽  
pp. 2428-2432 ◽  
Author(s):  
U. Mintz ◽  
L. Sachs
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
Peripheral Blood ◽  
Hodgkin's Disease ◽  
Hodgkin’S Disease ◽  
Peripheral Blood Lymphocytes ◽  
Lymphocytic Leukemia ◽  
Blood Lymphocytes

scholarly journals Visualization of tubulin in lymphocytes. I. Comparison of normal and chronic lymphocytic leukemia (CLL) lymphocytes

Blood ◽  
1978 ◽  
Vol 51 (6) ◽  
pp. 1031-1037 ◽  
Author(s):  
G Dighiero ◽  
E Karsenti ◽  
JY Follezou ◽  
M Bornens
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
Peripheral Blood ◽  
Normal Subjects ◽  
Peripheral Blood Lymphocytes ◽  
Lower Number ◽  
Lymphocytic Leukemia ◽  
Blood Lymphocytes ◽  
Cell Structures ◽  
Immunoperoxidase Assay

Abstract Cell structures containing tubulin were studied in peripheral blood lymphocytes from 8 normal donors and 11 patients with CLL using specific antitubulin antibodies revealed by immunoperoxidase assay. The centriole and microtubules were clearly visible in both groups. A “nucleus-associated tubulin-containing structure” was revealed by antitubulin antibodies and was found in virtually all lymphocytes of normal subjects but in a considerably lower number of CLL lymphocytes. The nature of this structure and its relationship to other cell structures are discussed.

scholarly journals Fetal Thymic Transplant in Patients With Hodgkin’s Disease

Blood ◽  
1973 ◽  
Vol 41 (5) ◽  
pp. 625-633 ◽  
Author(s):  
Roberto Marcolongo ◽  
Nicola Di Paolo
Keyword(s):  
Peripheral Blood ◽  
Hodgkin's Disease ◽  
Hodgkin’S Disease ◽  
Peripheral Blood Lymphocytes ◽  
Significant Rise ◽  
Immune Functions ◽  
Skin Sensitivity ◽  
Thymic Tissue ◽  
Blood Lymphocytes ◽  
Cellular Immune

Abstract Five patients with Hodgkin’s disease were treated by transplantation of fetal thymic tissue. Clinical and immunologic studies, carried out for over 5 mo thereafter, revealed a prompt improvement in previously defective cellular immune functions, including a significant rise of absolute lymphocytes in the peripheral blood and a normalization of tuberculin skin sensitivity and of the response of peripheral blood lymphocytes to phytohemagglutinin. It is suggested that fetal thymic transplant into patients with Hodgkin’s disease appears at present the best tool of improving their immunologic deficiency.

Cyclic AMP metabolism in peripheral blood lymphocytes from patients with Hodgkin's disease

1984 ◽  
Vol 20 (11) ◽  
pp. 1389-1392 ◽  
Author(s):  
Pradip N. Akolkar ◽  
Suresh H. Advani ◽  
Balwant P. Gothoskar
Keyword(s):  
Cyclic Amp ◽  
Peripheral Blood ◽  
Hodgkin's Disease ◽  
Hodgkin’S Disease ◽  
Peripheral Blood Lymphocytes ◽  
Blood Lymphocytes

scholarly journals Changes in Glycanic Determinants of Lymphocytes Membranes in Peripheral Blood in Patients with B-Cell Chronic Lymphocytic Leukemia under Antitumor Therapy

2021 ◽  
Vol 6 (6) ◽  
pp. 141-147
Author(s):  
G. S. Maslak ◽  
◽  
G. P. Chernenko ◽  
V. M. Baibakov ◽  
A. D. Viselko ◽  
...  
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
B Cell ◽  
Peripheral Blood ◽  
Peripheral Blood Lymphocytes ◽  
Lymphocytic Leukemia ◽  
Cytostatic Therapy ◽  
Tn Antigen ◽  
Antitumor Therapy ◽  
Blood Lymphocytes ◽  
Cell Chronic Lymphocytic Leukemia

The purpose of the study was to study the nature of changes in the exposure of surface glycans of peripheral blood lymphocytes in patients with B-cell chronic lymphocytic leukemia under conditions of antitumor therapy. Materials and methods. We studied the features of exposure of surface glycotopes of peripheral blood lymphocytes in patients with B-cell chronic lymphocytic leukemia under conditions of antitumor therapy using a set of seven lectins labeled with FITC and monoclonal antibodies to Tn-antigen- FITC for the detection of Tn antigen and CD43 exposure on blood lymphocytes. Cytostatic therapy included cyclophosphamide, vincristine (oncovin), prednisolone. Data were recorded on a Beckman Coulter EPICS flow cytometer. The results were processed using FCS3 Express. Results and discussion. The number of lymphocytes of healthy donors with a positive reaction to ConA, PHA-L, SNA, MAA-II and α1-acid glycoprotein amounted to 16.0±3.0%, 23.0±2.3%, 15.0±1.5%, 25.0±1.8% and 15.0±1.3%, respectively. The number of LABA-, UEA I-positive lymphocytes was 0.90±0.03% and 2.9±0.2%, respectively, and there was no binding to antibodies to Tn- and CD43-antigens. In the blood of patients with chronic lymphocytic leukemia, the level of ConA-, SNA- and MAA-II-positive lymphocytes increased relative to control by 2.2, 3.7 and 2.6 times, respectively. The number of LABA- and UEA I-positive lymphocytes in patients with chronic lymphocytic leukemia increased by 11 (p <0.01) and 23 (p <0.001) times and amounted to 10.5±0.5% and 67.5±5.5% respectively. The number of lymphocytes with CD43 antigen on their surface increased by 72 times, and the Tn antigen increased by 80 times. Cytostatic therapy reduced the level of LABA- and UEA I-positive lymphocytes by almost half, and MAA II-positive cells and lymphocytes interacting with antibodies to CD43 and Tn antigen by a third. The level of PHA-L-positive lymphocytes in the blood of chronic lymphocytic leukemia patients after undergoing alkylating therapy increased by 18.0±2.0% and almost did not differ from those obtained in the control group. Conclusion. 1. In chronic lymphocytic leukemia patients, the structure of glycoconjugates in peripheral blood lymphocytes changes, manifested in increased exposure of L-fucose, α-mannose and N-acetylneuraminic acid, which is confirmed by a significant increase in relation to the control of the number of ConA-, SNA-, MAA-II-, LABA I-positive cells. 2. Patients with chronic lymphocytic leukemia showed a significant increase in the number of lymphocytes, in which the markers of carcinogenesis CD43 and Tn antigens were found. 3. Cytostatic therapy significantly reduced the level of LABA-, UEA I- and MAA II-positive cells, as well as partially Tn- and CD43-antigen-positive lymphocytes, which indicates its positive effect on the treatment of chronic lymphocytic leukemia

scholarly journals Arginase activity alterations in peripheral blood lymphocytes in the human chronic lymphocytic leukemia.

1993 ◽  
Vol 40 (1) ◽  
pp. 160-163 ◽  
Author(s):  
L Konarska ◽  
I Widzyńska ◽  
H Zienkiewicz ◽  
K Sułek
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
Peripheral Blood ◽  
Peripheral Blood Lymphocytes ◽  
Lymphocytic Leukemia ◽  
Arginase Activity ◽  
Blood Lymphocytes

scholarly journals Fibrillar Bundles in the Nucleus of Blood Lymphocytes from Leukemic and Nonleukemic Patients

Blood ◽  
1970 ◽  
Vol 35 (2) ◽  
pp. 243-249 ◽  
Author(s):  
STEFANO S. STEFANI ◽  
HIROSHI TONAKI
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
Hodgkin's Disease ◽  
Hodgkin’S Disease ◽  
Lymphocytic Leukemia ◽  
Blood Lymphocytes ◽  
Normal Individuals

Abstract Fibrillar bundles were found in the nuclei of blood lymphocytes from 15 of 30 normal individuals. Similar fibrils were found in three of 16 cases of chronic lymphocytic leukemia, and in one of eight cases of Hodgkin’s disease. Nuclear bundles when observed in a sample were found only in small numbers. No points of continuity between the nuclear and the cytoplasmic fibrils could be found.

Immunologic studies of peripheral blood lymphocytes and lymph nodes in Hodgkin's disease: A preliminary report

1985 ◽  
Vol 52 (1) ◽  
pp. 69-72
Author(s):  
J. R. Cunningham ◽  
R. M. Bukowski ◽  
R. Valenzuela ◽  
R. Tubbs
Keyword(s):  
Lymph Nodes ◽  
Peripheral Blood ◽  
Hodgkin's Disease ◽  
Preliminary Report ◽  
Hodgkin’S Disease ◽  
Peripheral Blood Lymphocytes ◽  
Blood Lymphocytes

scholarly journals Chromosome Banding Analysis of Peripheral Blood Lymphocytes Stimulated with IL-2 and CpG Oligonucleotide DSP30 in Patients with Chronic Lymphocytic Leukemia

2013 ◽  
Vol 26 (4) ◽  
pp. 263-270 ◽  
Author(s):  
Kristina Štěpanovská ◽  
Gabriela Vaňková ◽  
Veronika Némethová ◽  
Lenka Tomášiková ◽  
Petra Šmuhařová ◽  
...  
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
Peripheral Blood ◽  
Chromosome Banding ◽  
Peripheral Blood Lymphocytes ◽  
Lymphocytic Leukemia ◽  
Blood Lymphocytes ◽  
Cpg Oligonucleotide ◽  
Banding Analysis ◽  
Chromosome Banding Analysis

Defect in lectin-induce interleukin 2 (IL-2) production by peripheral blood lymphocytes of patients with Hodgkin's Disease

1985 ◽  
Vol 21 (8) ◽  
pp. 935-939 ◽  
Author(s):  
J.P. Soulillou ◽  
J.Y. Douillard ◽  
H. Vie ◽  
J.L. Harousseau ◽  
J. Guenel ◽  
...  
Keyword(s):  
Peripheral Blood ◽  
Hodgkin's Disease ◽  
Hodgkin’S Disease ◽  
Interleukin 2 ◽  
Peripheral Blood Lymphocytes ◽  
Blood Lymphocytes
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