scholarly journals Regulation of nerve growth factor biosynthesis by beta-adrenergic receptor activation in astrocytoma cells: a potential role of c-Fos protein.

1989 ◽  
Vol 86 (10) ◽  
pp. 3891-3895 ◽  
Author(s):  
I. Mocchetti ◽  
M. A. De Bernardi ◽  
A. M. Szekely ◽  
H. Alho ◽  
G. Brooker ◽  
...  
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Adrenergic Receptor ◽  
Potential Role ◽  
Receptor Activation ◽  
Beta Adrenergic Receptor ◽  
Nerve Growth ◽  
Astrocytoma Cells ◽  
Fos Protein

The potential role of nerve growth factor in cryoneurolysis-induced neuropathic pain in rats

Cryobiology ◽  
2012 ◽  
Vol 65 (2) ◽  
pp. 132-138 ◽  
Author(s):  
Hui Ju ◽  
Yi Feng ◽  
Zhifeng Gao ◽  
Ba-Xian Yang
Keyword(s):  
Neuropathic Pain ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Potential Role ◽  
Nerve Growth

The Potential Role of Nerve Growth Factor (NGF) in Painful Neuromas and the Mechanism of Pain Relief by their Relocation to Muscle

2006 ◽  
Vol 31 (6) ◽  
pp. 652-656 ◽  
Author(s):  
D. D. ATHERTON ◽  
O. TAHERZADEH ◽  
P. FACER ◽  
D. ELLIOT ◽  
P. ANAND
Keyword(s):  
Nerve Growth Factor ◽  
Ion Channels ◽  
Growth Factor ◽  
Pain Relief ◽  
Sensory Neurons ◽  
Surgical Procedures ◽  
Potential Role ◽  
Nerve Growth ◽  
Pain Transmission

Painful neuromas have been successfully treated by surgical procedures including relocation to muscle, but the underlying molecular mechanism remains unclear. Nerve growth factor (NGF) is secreted by tissues and promotes the expression of ion channels and neuropeptides in sensory neurons involved in pain transmission. We hypothesised that excess of NGF may lead to pain in neuromas and that the efficacy of surgical relocation results from deprivation of NGF, i.e. translocation from NGF-rich regions, particularly sub-cutaneous structures associated with injury or inflammation, to NGF-poor structures such as muscle or bone. Using immunohistological methods with primary antibodies to rhNGF, we report that NGF levels were elevated in 13 painful neuromas in comparison with six control nerves. However, in four painful neuromata re-located into muscle with pain relief, the NGF level was similar to that of controls. NGF levels suggest an explanation for the development of painful neuromas and the efficacy of relocation.

scholarly journals Role of Nerve Growth Factor in Development and Persistence of Experimental Pulmonary Hypertension

2015 ◽  
Vol 192 (3) ◽  
pp. 342-355 ◽  
Author(s):  
Véronique Freund-Michel ◽  
Marcelina Cardoso Dos Santos ◽  
Christophe Guignabert ◽  
David Montani ◽  
Carole Phan ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Nerve Growth
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