scholarly journals Monoclonal antibodies specific for the outer surface protein A (OspA) of Borrelia burgdorferi prevent Lyme borreliosis in severe combined immunodeficiency (scid) mice.

1990 ◽  
Vol 87 (10) ◽  
pp. 3768-3772 ◽  
Author(s):  
U. E. Schaible ◽  
M. D. Kramer ◽  
K. Eichmann ◽  
M. Modolell ◽  
C. Museteanu ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
Borrelia Burgdorferi ◽  
Lyme Borreliosis ◽  
Outer Surface ◽  
Severe Combined Immunodeficiency ◽  
Protein A ◽  
Surface Protein ◽  
Scid Mice ◽  
Combined Immunodeficiency ◽  
Outer Surface Protein A

scholarly journals Immunogenicityof Borrelia burgdorferi Arthritis-RelatedProtein

2003 ◽  
Vol 71 (12) ◽  
pp. 7211-7214 ◽  
Author(s):  
Sunlian Feng ◽  
Emir Hodzic ◽  
Kimberly Freet ◽  
Stephen W. Barthold
Keyword(s):  
Borrelia Burgdorferi ◽  
Outer Surface ◽  
Protein A ◽  
Surface Protein ◽  
Passive Transfer ◽  
Scid Mice ◽  
Related Protein ◽  
Peptide Fragments ◽  
Outer Surface Protein A ◽  
Outer Surface Protein

ABSTRACT Immunization against arthritis-related protein (Arp) elicits antibody in mice that resolves arthritis but is not protective against challenge with Borrelia burgdorferi. In mice immunized against Arp, an unrelated 37-kDa protein (P37-42), outer surface protein A (OspA), or glutathione S-transferase (GT) and then challenged by syringe or tick, only OspA conferred protection. Passive transfer of Arp antiserum into infected SCID mice induced arthritis resolution, but antisera to P37-42, OspA, GT, or six overlapping Arp peptide fragments did not. Results suggest that the arthritis-resolving immunogenicity is specific to Arp, but the relevant epitopes may be conformational.

Multiple cross-reactive seif-ligands for Borrelia burgdorferi outer surface protein A (OspA)-specific HLA-DR4-restricted T Cells

1999 ◽  
Vol 289 (5-7) ◽  
pp. 673 ◽  
Author(s):  
Bert Maier ◽  
Marc Molinger ◽  
Andrew P. Cope ◽  
Lars Fugger ◽  
Jens Schneider-Mergener ◽  
...  
Keyword(s):  
T Cells ◽  
Borrelia Burgdorferi ◽  
Outer Surface ◽  
Protein A ◽  
Surface Protein ◽  
Outer Surface Protein A ◽  
Outer Surface Protein ◽  
Multiple Cross

Immunogenicity of a recombinant Borrelia burgdorferi outer surface protein A vaccine against Lyme disease in children

1999 ◽  
Vol 135 (5) ◽  
pp. 575-579 ◽  
Author(s):  
Henry M. Feder ◽  
Jeri Beran ◽  
Christian Van Hoecke ◽  
Betsy Abraham ◽  
Norbert De Clercq ◽  
...  
Keyword(s):  
Lyme Disease ◽  
Borrelia Burgdorferi ◽  
Outer Surface ◽  
Protein A ◽  
Surface Protein ◽  
Outer Surface Protein A ◽  
Outer Surface Protein
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