scholarly journals Excess brain protein oxidation and enzyme dysfunction in normal aging and in Alzheimer disease.

1991 ◽  
Vol 88 (23) ◽  
pp. 10540-10543 ◽  
Author(s):  
C. D. Smith ◽  
J. M. Carney ◽  
P. E. Starke-Reed ◽  
C. N. Oliver ◽  
E. R. Stadtman ◽  
...  
Keyword(s):  
Alzheimer Disease ◽  
Protein Oxidation ◽  
Normal Aging ◽  
Brain Protein

scholarly journals Regional rates of neocortical atrophy from normal aging to early Alzheimer disease

Neurology ◽  
2009 ◽  
Vol 73 (6) ◽  
pp. 457-465 ◽  
Author(s):  
C. R. McDonald ◽  
L. K. McEvoy ◽  
L. Gharapetian ◽  
C. Fennema-Notestine ◽  
D. J. Hagler ◽  
...  
Keyword(s):  
Alzheimer Disease ◽  
Normal Aging

Making and Remaking Alzheimer Disease

2013 ◽  
Author(s):  
Margaret Lock
Keyword(s):  
Alzheimer Disease ◽  
Normal Aging ◽  
Research Paradigm ◽  
Amyloid Cascade Hypothesis ◽  
The Past ◽  
Localization Theory ◽  
Initial Identification ◽  
Aging Populations ◽  
Amyloid Cascade

This chapter focuses on the “discovery” of Alzheimer disease (AD) and a somewhat condensed genealogy of its history to the present time. Emphasis is given to the virtual disappearance of AD for over four decades after its initial identification, followed by its rediscovery in the late 1960s in association with government and medical recognition of aging populations and their impending burden on society. The chapter also discusses the consolidation of what has been the dominant research paradigm in AD research for the past four decades-the amyloid cascade hypothesis, grounded in localization theory. Throughout the study, difficulties in attempting to unravel the entanglement of “normal” aging from dementia, evident from Alois Alzheimer's time, are pointed out.

scholarly journals Hippocampal Sclerosis but Not Normal Aging or Alzheimer Disease Is Associated With TDP-43 Pathology in the Basal Forebrain of Aged Persons

2016 ◽  
Vol 75 (5) ◽  
pp. 397-407 ◽  
Author(s):  
Matthew D. Cykowski ◽  
Hidehiro Takei ◽  
Linda J. Van Eldik ◽  
Frederick A. Schmitt ◽  
Gregory A. Jicha ◽  
...  
Keyword(s):  
Alzheimer Disease ◽  
Basal Forebrain ◽  
Hippocampal Sclerosis ◽  
Normal Aging

Brain Atrophy Rates in Normal Aging and Alzheimer Disease

2017 ◽  
Vol 1 (1) ◽  
pp. 01-02
Author(s):  
Micki Dexte
Keyword(s):  
Clinical Trials ◽  
Alzheimer Disease ◽  
Entorhinal Cortex ◽  
Brain Atrophy ◽  
Hippocampal Volume ◽  
Normal Aging ◽  
Hippocampal Atrophy ◽  
Healthy Controls ◽  
Volume Changes ◽  
Longitudinal Mri

The objectives of this study were to (1) compare atrophy rates associated with normal aging and Alzheimer disease (AD) using the semi-automated Boundary Shift Integral (BSI) method and manual tracing of the entorhinal cortex (ERC) and hippocampus and (2) calculate power of BSI vs. ERC and hippocampal volume changes for clinical trials in AD. We quantified whole brain and ventricular BSI atrophy rates and ERC and hippocampal atrophy rates from longitudinal MRI data in 20 AD patients and 22 age-matched healthy controls.

scholarly journals Neocortical Synapse Density and Braak Stage in the Lewy Body Variant of Alzheimer Disease: A Comparison with Classic Alzheimer Disease and Normal Aging

1998 ◽  
Vol 57 (10) ◽  
pp. 955-960 ◽  
Author(s):  
Daniel F. Brown ◽  
Richard C. Risser ◽  
Eileen H. Bigio ◽  
Patrick Tripp ◽  
Ashley Stiegler ◽  
...  
Keyword(s):  
Alzheimer Disease ◽  
Lewy Body ◽  
Normal Aging ◽  
Braak Stage ◽  
Synapse Density ◽  
Lewy Body Variant
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