scholarly journals Quantitative analysis of senile plaques in Alzheimer disease: observation of log-normal size distribution and molecular epidemiology of differences associated with apolipoprotein E genotype and trisomy 21 (Down syndrome).

1995 ◽  
Vol 92 (8) ◽  
pp. 3586-3590 ◽  
Author(s):  
B. T. Hyman ◽  
H. L. West ◽  
G. W. Rebeck ◽  
S. V. Buldyrev ◽  
R. N. Mantegna ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Quantitative Analysis ◽  
Alzheimer Disease ◽  
Apolipoprotein E ◽  
Molecular Epidemiology ◽  
Size Distribution ◽  
Trisomy 21 ◽  
Senile Plaques ◽  
Log Normal ◽  
Apolipoprotein E Genotype

Association of apolipoprotein E genotype with brain levels of apolipoprotein E and apolipoprotein J (clusterin) in Alzheimer disease

1995 ◽  
Vol 33 (1) ◽  
pp. 174-178 ◽  
Author(s):  
Philippe Bertrand ◽  
Judes Poirier ◽  
Tomiichiro Oda ◽  
Caleb E. Finch ◽  
Giulio Maria Pasinetti
Keyword(s):  
Alzheimer Disease ◽  
Apolipoprotein E ◽  
Brain Levels ◽  
Apolipoprotein J ◽  
Apolipoprotein E Genotype

Apolipoprotein E genotype and amyloid load in Alzheimer disease and control brains

1997 ◽  
Vol 18 (1) ◽  
pp. 121-127 ◽  
Author(s):  
T. Pirttilä ◽  
H. Soininen ◽  
P.D. Mehta ◽  
O. Heinonen ◽  
T. Lehtimäki ◽  
...  
Keyword(s):  
Alzheimer Disease ◽  
Apolipoprotein E ◽  
Amyloid Load ◽  
And Control ◽  
Apolipoprotein E Genotype

scholarly journals Apolipoprotein E Genotype and Deposits of Aβ40 and Aβ42 in Alzheimer Disease

1998 ◽  
Vol 55 (7) ◽  
pp. 1001 ◽  
Author(s):  
Megan J. McNamara ◽  
Teresa Gomez-Isla ◽  
Bradley T. Hyman
Keyword(s):  
Alzheimer Disease ◽  
Apolipoprotein E ◽  
Apolipoprotein E Genotype

Intraneuronal Aβ-Amyloid Precedes Development of Amyloid Plaques in Down Syndrome

2001 ◽  
Vol 125 (4) ◽  
pp. 489-492 ◽  
Author(s):  
Kymberly A. Gyure ◽  
Robert Durham ◽  
Walter F. Stewart ◽  
John E. Smialek ◽  
Juan C. Troncoso
Keyword(s):  
Down Syndrome ◽  
Alzheimer Disease ◽  
Neurofibrillary Tangles ◽  
Senile Plaques ◽  
Medical Examiner ◽  
Johns Hopkins Hospital ◽  
Sequence Of Events ◽  
Amyloid Deposits ◽  
Aβ Amyloid ◽  
Intraneuronal Aβ

Abstract Context.—Down syndrome patients who live to middle age invariably develop the neuropathologic features of Alzheimer disease, providing a unique situation in which to study the early and sequential development of these changes. Objective.—To study the development of amyloid deposits, senile plaques, astrocytic and microglial reactions, and neurofibrillary tangles in the brains of young individuals (<30 years of age) with Down syndrome. Methods.—Histologic and immunocytochemical study of a series of autopsy brains (n = 14, from subjects aged 11 months to 56 years, with 9 subjects <30 years) examined at the Office of the Chief Medical Examiner of the State of Maryland and The Johns Hopkins Hospital. Results.—The principal observations included the presence of intraneuronal Aβ immunostaining in the hippocampus and cerebral cortex of very young Down syndrome patients (preceding the extracellular deposition of Aβ) and the formation of senile plaques and neurofibrillary tangles. Conclusions.—We propose the following sequence of events in the development of neuropathologic changes of Alzheimer disease in Down syndrome: (1) intracellular accumulation of Aβ in neurons and astrocytes, (2) deposition of extracellular Aβ and formation of diffuse plaques, and (3) development of neuritic plaques and neurofibrillary tangles with activation of microglial cells.

scholarly journals Age and the association between apolipoprotein E genotype and Alzheimer disease: A cerebrospinal fluid biomarker–based case–control study

PLoS Medicine ◽  
2020 ◽  
Vol 17 (8) ◽  
pp. e1003289 ◽  
Author(s):  
Hana Saddiki ◽  
Aurore Fayosse ◽  
Emmanuel Cognat ◽  
Séverine Sabia ◽  
Sebastiaan Engelborghs ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Alzheimer Disease ◽  
Apolipoprotein E ◽  
Case Control Study ◽  
Case Control ◽  
Fluid Biomarker ◽  
Control Study ◽  
Apolipoprotein E Genotype

Apolipoprotein E Genotype Influences Presence and Severity of Delusions and Aggressive Behavior in Alzheimer Disease

2006 ◽  
Vol 23 (1) ◽  
pp. 42-46 ◽  
Author(s):  
Wiesje M. van der Flier ◽  
Salka Staekenborg ◽  
Yolande A.L. Pijnenburg ◽  
Freek Gillissen ◽  
Rolinka Romkes ◽  
...  
Keyword(s):  
Alzheimer Disease ◽  
Apolipoprotein E ◽  
Aggressive Behavior ◽  
Apolipoprotein E Genotype
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