scholarly journals Cockayne syndrome group B protein enhances elongation by RNA polymerase II

1997 ◽  
Vol 94 (21) ◽  
pp. 11205-11209 ◽  
Author(s):  
C. P. Selby ◽  
A. Sancar
Keyword(s):  
Rna Polymerase ◽  
Rna Polymerase Ii ◽  
Cockayne Syndrome ◽  
Group B

scholarly journals The Stalling of Transcription at Abasic Sites Is Highly Mutagenic

2003 ◽  
Vol 23 (1) ◽  
pp. 382-388 ◽  
Author(s):  
Sung-Lim Yu ◽  
Sung-Keun Lee ◽  
Robert E. Johnson ◽  
Louise Prakash ◽  
Satya Prakash
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Rna Polymerase ◽  
Rna Polymerase Ii ◽  
Cockayne Syndrome ◽  
Abasic Sites ◽  
Dramatic Rise ◽  
Ap Sites ◽  
Group B

ABSTRACT Abasic (AP) sites represent one of the most frequently formed lesions in DNA. Here, we examine the consequences of the stalling of RNA polymerase II at AP sites in DNA in Saccharomyces cerevisiae. A severe inhibition of transcription occurs in strains that are defective in the removal of AP sites and that also lack the RAD26 gene, a homolog of the human Cockayne syndrome group B (CSB) gene, and, importantly, a dramatic rise in mutagenesis is incurred in such strains. From the various observations presented here, we infer that the stalling of transcription at AP sites is highly mutagenic.

scholarly journals Reduced RNA polymerase II transcription in intact and permeabilized Cockayne syndrome group B cells

1997 ◽  
Vol 94 (9) ◽  
pp. 4306-4311 ◽  
Author(s):  
A. S. Balajee ◽  
A. May ◽  
G. L. Dianov ◽  
E. C. Friedberg ◽  
V. A. Bohr
Keyword(s):  
B Cells ◽  
Rna Polymerase ◽  
Rna Polymerase Ii ◽  
Cockayne Syndrome ◽  
Group B ◽  
Rna Polymerase Ii Transcription

scholarly journals Evidence that the Transcription Elongation Function of Rpb9 Is Involved in Transcription-Coupled DNA Repair in Saccharomyces cerevisiae

2006 ◽  
Vol 26 (24) ◽  
pp. 9430-9441 ◽  
Author(s):  
Shisheng Li ◽  
Baojin Ding ◽  
Runqiang Chen ◽  
Christine Ruggiero ◽  
Xuefeng Chen
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Dna Repair ◽  
Rna Polymerase ◽  
Rna Polymerase Ii ◽  
Transcription Elongation ◽  
Elongation Factor ◽  
Complementation Group ◽  
Cockayne Syndrome ◽  
Transcription Repression ◽  
Group B

ABSTRACT Rpb9, a small nonessential subunit of RNA polymerase II, has been shown to have multiple transcription-related functions in Saccharomyces cerevisiae. These functions include promoting transcription elongation and mediating a subpathway of transcription-coupled repair (TCR) that is independent of Rad26, the homologue of human Cockayne syndrome complementation group B protein. Rpb9 is composed of three distinct domains: the N-terminal Zn1, the C-terminal Zn2, and the central linker. Here we show that the Zn1 and linker domains are essential, whereas the Zn2 domain is almost dispensable, for both transcription elongation and TCR functions. Impairment of transcription elongation, which does not dramatically compromise Rad26-mediated TCR, completely abolishes Rpb9-mediated TCR. Furthermore, Rpb9 appears to be dispensable for TCR if its transcription elongation function is compensated for by removing a transcription repression/elongation factor. Our data suggest that the transcription elongation function of Rpb9 is involved in TCR.

scholarly journals Recognition of RNA Polymerase II and Transcription Bubbles by XPG, CSB, and TFIIH: Insights for Transcription-Coupled Repair and Cockayne Syndrome

2005 ◽  
Vol 20 (2) ◽  
pp. 187-198 ◽  
Author(s):  
Altaf H. Sarker ◽  
Susan E. Tsutakawa ◽  
Seth Kostek ◽  
Cliff Ng ◽  
David S. Shin ◽  
...  
Keyword(s):  
Rna Polymerase ◽  
Rna Polymerase Ii ◽  
Cockayne Syndrome ◽  
Transcription Coupled Repair

scholarly journals The Cockayne syndrome group A gene encodes a WD repeat protein that interacts with CSB protein and a subunit of RNA polymerase II TFIIH

Cell ◽  
1995 ◽  
Vol 82 (4) ◽  
pp. 555-564 ◽  
Author(s):  
Karla A. Henning ◽  
Lei Li ◽  
Narayan Iyer ◽  
Lisa D. McDaniel ◽  
Michael S. Reagan ◽  
...  
Keyword(s):  
Rna Polymerase ◽  
Rna Polymerase Ii ◽  
Cockayne Syndrome ◽  
Repeat Protein ◽  
Group A ◽  
A Subunit ◽  
Wd Repeat

scholarly journals UV-induced proteolysis of RNA polymerase II is mediated by VCP/p97 segregase and timely orchestration by Cockayne syndrome B protein

Oncotarget ◽  
2016 ◽  
Vol 8 (7) ◽  
pp. 11004-11019 ◽  
Author(s):  
Jinshan He ◽  
Qianzheng Zhu ◽  
Gulzar Wani ◽  
Altaf A. Wani
Keyword(s):  
Rna Polymerase ◽  
Rna Polymerase Ii ◽  
Cockayne Syndrome
Sign in / Sign up

Export Citation Format

Share Document