scholarly journals The Ath5 proneural genes function upstream of Brn3 POU domain transcription factor genes to promote retinal ganglion cell development

2001 ◽  
Vol 98 (4) ◽  
pp. 1649-1654 ◽  
Author(s):  
W. Liu ◽  
Z. Mo ◽  
M. Xiang
Keyword(s):  
Transcription Factor ◽  
Ganglion Cell ◽  
Retinal Ganglion Cell ◽  
Cell Development ◽  
Retinal Ganglion ◽  
Proneural Genes ◽  
Pou Domain ◽  
Transcription Factor Genes

All Brn3 genes can promote retinal ganglion cell differentiation in the chick

Development ◽  
2000 ◽  
Vol 127 (15) ◽  
pp. 3237-3247 ◽  
Author(s):  
W. Liu ◽  
S.L. Khare ◽  
X. Liang ◽  
M.A. Peters ◽  
X. Liu ◽  
...  
Keyword(s):  
Ganglion Cell ◽  
Retinal Ganglion Cell ◽  
Ganglion Cells ◽  
Cell Development ◽  
Large Set ◽  
Retinal Ganglion ◽  
Pou Domain ◽  
Temporal Expression Pattern ◽  
Cell Genesis

Targeted gene disruption studies in the mouse have demonstrated crucial roles for the Brn3 POU domain transcription factor genes, Brn3a, Brn3b, Brn3c (now called Pou4f1, Pou4f2, Pou4f3, respectively) in sensorineural development and survival. During mouse retinogenesis, the Brn3b gene is expressed in a large set of postmitotic ganglion cell precursors and is required for their early and terminal differentiation. In contrast, the Brn3a and Brn3c genes, which are expressed later in ganglion cells, appear to be dispensable for ganglion cell development. To understand the mechanism that causes the functional differences of Brn3 genes in retinal development, we employed a gain-of-function approach in the chick embryo. We find that Brn3b(l) and Brn3b(s), the two isoforms encoded by the Brn3b gene, as well as Brn3a and Brn3c all have similar DNA-binding and transactivating activities. We further find that the POU domain is minimally required for these activities. Consequently, we show that all these Brn3 proteins have a similar ability to promote development of ganglion cells when ectopically expressed in retinal progenitors. During chick retinogenesis, cBrn3c instead of cBrn3b exhibits a spatial and temporal expression pattern characteristic of ganglion cell genesis and its misexpression can also increase ganglion cell production. Based on these data, we propose that all Brn3 factors are capable of promoting retinal ganglion cell development, and that this potential may be limited by the order of expression in vivo.

Author response for "Identification of Retinal Ganglion Cell Types and Brain Nuclei expressing the transcription factor Brn3c/Pou4f3 using a Cre recombinase knock‐in allele"

2020 ◽  
Author(s):  
Nadia Parmhans ◽  
Anne Drury Fuller ◽  
Eileen Nguyen ◽  
Katherine Chuang ◽  
David Swygart ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Ganglion Cell ◽  
Retinal Ganglion Cell ◽  
Cell Types ◽  
Cre Recombinase ◽  
Author Response ◽  
Retinal Ganglion ◽  
Brain Nuclei

Identification of retinal ganglion cell types expressing the transcription factor Satb2 in three primate species

2021 ◽  
Author(s):  
Subha Nasir‐Ahmad ◽  
Sammy C. S. Lee ◽  
Paul R. Martin ◽  
Ulrike Grünert
Keyword(s):  
Transcription Factor ◽  
Ganglion Cell ◽  
Retinal Ganglion Cell ◽  
Cell Types ◽  
Primate Species ◽  
Retinal Ganglion

Pou4f2-GFPknock-in mouse line: A model for studying retinal ganglion cell development

genesis ◽  
2016 ◽  
Vol 54 (10) ◽  
pp. 534-541 ◽  
Author(s):  
Dongwang Zheng ◽  
Xiaoyan Yang ◽  
Donglai Sheng ◽  
Dongliang Yu ◽  
Guoqing Liang ◽  
...  
Keyword(s):  
Ganglion Cell ◽  
Retinal Ganglion Cell ◽  
Cell Development ◽  
Retinal Ganglion ◽  
Mouse Line

scholarly journals Molecular characterization and mapping of ATOH7, a human atonal homolog with a predicted role in retinal ganglion cell development

2002 ◽  
Vol 13 (2) ◽  
pp. 95-101 ◽  
Author(s):  
Nadean L. Brown ◽  
Susan L. Dagenais ◽  
Chuan-Min Chen ◽  
Tom Glaser
Keyword(s):  
Ganglion Cell ◽  
Molecular Characterization ◽  
Retinal Ganglion Cell ◽  
Cell Development ◽  
Retinal Ganglion

scholarly journals Two new genetically modified mouse alleles labeling distinct phases of retinal ganglion cell development by fluorescent proteins

2020 ◽  
Vol 249 (12) ◽  
pp. 1514-1528 ◽  
Author(s):  
Yichen Ge ◽  
Fuguo Wu ◽  
Mobin Cheng ◽  
Jonathan Bard ◽  
Xiuqian Mu
Keyword(s):  
Ganglion Cell ◽  
Retinal Ganglion Cell ◽  
Fluorescent Proteins ◽  
Genetically Modified ◽  
Cell Development ◽  
Retinal Ganglion

scholarly journals Disease Gene Candidates Revealed by Expression Profiling of Retinal Ganglion Cell Development

2007 ◽  
Vol 27 (32) ◽  
pp. 8593-8603 ◽  
Author(s):  
J. T. Wang ◽  
N. J. Kunzevitzky ◽  
J. C. Dugas ◽  
M. Cameron ◽  
B. A. Barres ◽  
...  
Keyword(s):  
Ganglion Cell ◽  
Retinal Ganglion Cell ◽  
Expression Profiling ◽  
Disease Gene ◽  
Cell Development ◽  
Retinal Ganglion
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