Subunit Interface Selectivity of the α-Neurotoxins for the Nicotinic Acetylcholine Receptor

Journal of Biological Chemistry ◽

10.1074/jbc.274.14.9581 ◽

1999 ◽

Vol 274 (14) ◽

pp. 9581-9586 ◽

Author(s):

Hitoshi Osaka ◽

Siobhan Malany ◽

Joan R. Kanter ◽

Steven M. Sine ◽

Palmer Taylor

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Nicotinic Acetylcholine ◽

Subunit Interface

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A Transmembrane Binding Site at a Subunit Interface for Torpedo Nicotinic Acetylcholine Receptor Potentiators And Inhibitors

Biophysical Journal ◽

10.1016/j.bpj.2009.12.708 ◽

2010 ◽

Vol 98 (3) ◽

pp. 131a

Author(s):

Ayman K. Hamouda ◽

Deidre Stewart ◽

S. Shaukat Husain ◽

Jonathan B. Cohen

Keyword(s):

Binding Site ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Nicotinic Acetylcholine ◽

Subunit Interface ◽

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Subunit interface selective toxins as probes of nicotinic acetylcholine receptor structure

Pflügers Archiv - European Journal of Physiology ◽

10.1007/s004240000028 ◽

2000 ◽

Vol 440 (S1) ◽

pp. R115-R117 ◽

Author(s):

Palmer Taylor ◽

Siobhan Malany ◽

Brian E. Molles ◽

Hitoshi Osaka ◽

Igor Tsigelny

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Nicotinic Acetylcholine ◽

Receptor Structure ◽

Subunit Interface

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A high-affinity site for acetylcholine occurs close to the .alpha.-.gamma. subunit interface of Torpedo nicotinic acetylcholine receptor

Biochemistry ◽

10.1021/bi00084a032 ◽

1993 ◽

Vol 32 (33) ◽

pp. 8616-8621 ◽

Author(s):

Susan M. J. Dunn ◽

Bianca M. Conti-Tronconi ◽

Michael A. Raftery

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Nicotinic Acetylcholine ◽

Gamma Subunit ◽

High Affinity ◽

Subunit Interface ◽

High Affinity Site

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Residues in the ε Subunit of the Nicotinic Acetylcholine Receptor Interact To Confer Selectivity of Waglerin-1 for the α−ε Subunit Interface Site†

Biochemistry ◽

10.1021/bi025732d ◽

2002 ◽

Vol 41 (25) ◽

pp. 7895-7906 ◽

Author(s):

Brian E. Molles ◽

Igor Tsigelny ◽

Phuong D. Nguyen ◽

Sarah X. Gao ◽

Steven M. Sine ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Nicotinic Acetylcholine ◽

Subunit Interface

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Efficacy of Varenicline, an α4β2 Nicotinic Acetylcholine Receptor Partial Agonist, vs Placebo or Sustained-Release Bupropion for Smoking Cessation: A Randomized Controlled Trial

Yearbook of Pulmonary Disease ◽

10.1016/s8756-3452(08)70598-x ◽

2008 ◽

Vol 2008 ◽

pp. 109-110

Author(s):

L.T. Tanoue

Keyword(s):

Randomized Controlled Trial ◽

Smoking Cessation ◽

Sustained Release ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Partial Agonist ◽

Controlled Trial ◽

Nicotinic Acetylcholine ◽

Randomized Controlled

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Varenicline, an α4β2 Nicotinic Acetylcholine Receptor Partial Agonist, vs Sustained-Release Bupropion and Placebo for Smoking Cessation: A Randomized Controlled Trial

Yearbook of Medicine ◽

10.1016/s0084-3873(08)70096-8 ◽

2007 ◽

Vol 2007 ◽

pp. 143-145

Author(s):

N.H. Hanna

Keyword(s):

Randomized Controlled Trial ◽

Smoking Cessation ◽

Sustained Release ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Partial Agonist ◽

Controlled Trial ◽

Nicotinic Acetylcholine ◽

Randomized Controlled

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Faculty Opinions recommendation of Decreased signs of nicotine withdrawal in mice null for the beta4 nicotinic acetylcholine receptor subunit.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1022312.254647 ◽

2004 ◽

Author(s):

Marina Picciotto

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Nicotine Withdrawal ◽

Receptor Subunit ◽

Nicotinic Acetylcholine

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Faculty Opinions recommendation of Peptide-toxin tools for probing the expression and function of fetal and adult subtypes of the nicotinic acetylcholine receptor.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1116372.572388 ◽

2008 ◽

Author(s):

David J Adams

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Nicotinic Acetylcholine ◽

Peptide Toxin ◽

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Faculty Opinions recommendation of Alpha7 nicotinic acetylcholine receptor activation ameliorates scopolamine-induced behavioural changes in a modified continuous Y-maze task in mice.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1146929.604026 ◽

2009 ◽

Author(s):

Jerry Buccafusco

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Receptor Activation ◽

Maze Task ◽

Nicotinic Acetylcholine ◽

Alpha7 Nicotinic Acetylcholine Receptor ◽

Behavioural Changes ◽

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Faculty Opinions recommendation of A novel nicotinic acetylcholine receptor subtype in basal forebrain cholinergic neurons with high sensitivity to amyloid peptides.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1147992.605097 ◽

2009 ◽

Author(s):

Jerry Buccafusco

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Basal Forebrain ◽

Cholinergic Neurons ◽

High Sensitivity ◽

Receptor Subtype ◽

Nicotinic Acetylcholine ◽

Amyloid Peptides ◽

Basal Forebrain Cholinergic Neurons

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