A high-affinity site for acetylcholine occurs close to the .alpha.-.gamma. subunit interface of Torpedo nicotinic acetylcholine receptor

Biochemistry ◽  
1993 ◽  
Vol 32 (33) ◽  
pp. 8616-8621 ◽  
Author(s):  
Susan M. J. Dunn ◽  
Bianca M. Conti-Tronconi ◽  
Michael A. Raftery
Keyword(s):  
Acetylcholine Receptor ◽  
Nicotinic Acetylcholine Receptor ◽  
Nicotinic Acetylcholine ◽  
Gamma Subunit ◽  
High Affinity ◽  
Subunit Interface ◽  
High Affinity Site

Subunit interface selective toxins as probes of nicotinic acetylcholine receptor structure

2000 ◽  
Vol 440 (S1) ◽  
pp. R115-R117 ◽  
Author(s):  
Palmer Taylor ◽  
Siobhan Malany ◽  
Brian E. Molles ◽  
Hitoshi Osaka ◽  
Igor Tsigelny
Keyword(s):  
Acetylcholine Receptor ◽  
Nicotinic Acetylcholine Receptor ◽  
Nicotinic Acetylcholine ◽  
Receptor Structure ◽  
Subunit Interface

scholarly journals Subunit Interface Selectivity of the α-Neurotoxins for the Nicotinic Acetylcholine Receptor

1999 ◽  
Vol 274 (14) ◽  
pp. 9581-9586 ◽  
Author(s):  
Hitoshi Osaka ◽  
Siobhan Malany ◽  
Joan R. Kanter ◽  
Steven M. Sine ◽  
Palmer Taylor
Keyword(s):  
Acetylcholine Receptor ◽  
Nicotinic Acetylcholine Receptor ◽  
Nicotinic Acetylcholine ◽  
Subunit Interface

scholarly journals Insecticidal spider toxins are high affinity positive allosteric modulators of the nicotinic acetylcholine receptor

FEBS Letters ◽  
2019 ◽  
Vol 593 (12) ◽  
pp. 1336-1350 ◽  
Author(s):  
Chris Chambers ◽  
Penny Cutler ◽  
Yen‐Hua Huang ◽  
James A. Goodchild ◽  
Judith Blythe ◽  
...  
Keyword(s):  
Acetylcholine Receptor ◽  
Nicotinic Acetylcholine Receptor ◽  
Allosteric Modulators ◽  
Nicotinic Acetylcholine ◽  
High Affinity ◽  
Spider Toxins ◽  
Positive Allosteric Modulators
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