scholarly journals Clustering of the Neural Cell Adhesion Molecule (NCAM) at the Neuronal Cell Surface Induces Caspase-8- and -3-dependent Changes of the Spectrin Meshwork Required for NCAM-mediated Neurite Outgrowth

2010 ◽  
Vol 285 (53) ◽  
pp. 42046-42057 ◽  
Author(s):  
Doreen Westphal ◽  
Vladimir Sytnyk ◽  
Melitta Schachner ◽  
Iryna Leshchyns'ka
Keyword(s):  
Cell Adhesion ◽  
Cell Surface ◽  
Neurite Outgrowth ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Neural Cell Adhesion Molecule ◽  
Neuronal Cell ◽  
Neural Cell ◽  
Caspase 8 ◽  
Neural Cell Adhesion

Enhancement of neurite outgrowth by the soluble form of human L1 (neural cell adhesion molecule)

Neuroreport ◽  
1997 ◽  
Vol 8 (14) ◽  
pp. 3157-3162 ◽  
Author(s):  
Makoto Sugawa ◽  
Katsuhiko Ono ◽  
Yukihiko Yasui ◽  
Toshiro Kishi ◽  
Toshiko Tsumori
Keyword(s):  
Cell Adhesion ◽  
Neurite Outgrowth ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Neural Cell Adhesion Molecule ◽  
Neural Cell ◽  
Soluble Form ◽  
Neural Cell Adhesion

Neural cell adhesion molecule-mediated neurite outgrowth is repressed by overexpression of HES-1

2002 ◽  
Vol 71 (1) ◽  
pp. 1-6 ◽  
Author(s):  
Ulla Jessen ◽  
Vera Novitskaya ◽  
Peter S. Walmod ◽  
Vladimir Berezin ◽  
Elisabeth Bock
Keyword(s):  
Cell Adhesion ◽  
Neurite Outgrowth ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Neural Cell Adhesion Molecule ◽  
Neural Cell ◽  
Neural Cell Adhesion

scholarly journals Ganglioside modulation of neural cell adhesion molecule and N-cadherin-dependent neurite outgrowth

1992 ◽  
Vol 117 (5) ◽  
pp. 1093-1099 ◽  
Author(s):  
P Doherty ◽  
SV Ashton ◽  
SD Skaper ◽  
A Leon ◽  
FS Walsh
Keyword(s):  
Cell Adhesion ◽  
Neurite Outgrowth ◽  
Pc12 Cells ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Neural Cell Adhesion Molecule ◽  
Calcium Influx ◽  
Neural Cell ◽  
3T3 Cells ◽  
Neural Cell Adhesion

We have used monolayers of control 3T3 cells and 3T3 cells expressing transfected human neural cell adhesion molecule (NCAM) or chick N-cadherin as a culture substrate for PC12 cells. NCAM and N-cadherin in the monolayer directly promote neurite outgrowth from PC12 cells via a G-protein-dependent activation of neuronal calcium channels. In the present study we show that ganglioside GM1 does not directly activate this pathway in PC12 cells. However, the presence of GM1 (12.5-100 micrograms/ml) in the co-culture was associated with a potentiation of NCAM and N-cadherin-dependent neurite outgrowth. Treatment of PC12 cells with GM1 (100 micrograms/ml) for 90 min led to trypsin-stable increases in both beta-cholera toxin binding to PC12 cells and an enhanced neurite outgrowth response to N-cadherin. The ganglioside response could be fully inhibited by treatment with pertussis toxin. These data are consistent with exogenous gangliosides enhancing neuritic growth by promoting cell adhesion molecule-induced calcium influx into neurons.

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