Cyclic guanosine monophosphate signalling pathway plays a role in neural cell adhesion molecule-mediated neurite outgrowth and survival

2007 ◽  
Vol 85 (4) ◽  
pp. 703-711 ◽  
Author(s):  
Dorte Kornerup Ditlevsen ◽  
Lene Boding Køhler ◽  
Vladimir Berezin ◽  
Elisabeth Bock
Keyword(s):  
Cell Adhesion ◽  
Neurite Outgrowth ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Neural Cell Adhesion Molecule ◽  
Cyclic Guanosine Monophosphate ◽  
Neural Cell ◽  
Signalling Pathway ◽  
Guanosine Monophosphate ◽  
Neural Cell Adhesion

Enhancement of neurite outgrowth by the soluble form of human L1 (neural cell adhesion molecule)

Neuroreport ◽  
1997 ◽  
Vol 8 (14) ◽  
pp. 3157-3162 ◽  
Author(s):  
Makoto Sugawa ◽  
Katsuhiko Ono ◽  
Yukihiko Yasui ◽  
Toshiro Kishi ◽  
Toshiko Tsumori
Keyword(s):  
Cell Adhesion ◽  
Neurite Outgrowth ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Neural Cell Adhesion Molecule ◽  
Neural Cell ◽  
Soluble Form ◽  
Neural Cell Adhesion

Neural cell adhesion molecule-mediated neurite outgrowth is repressed by overexpression of HES-1

2002 ◽  
Vol 71 (1) ◽  
pp. 1-6 ◽  
Author(s):  
Ulla Jessen ◽  
Vera Novitskaya ◽  
Peter S. Walmod ◽  
Vladimir Berezin ◽  
Elisabeth Bock
Keyword(s):  
Cell Adhesion ◽  
Neurite Outgrowth ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Neural Cell Adhesion Molecule ◽  
Neural Cell ◽  
Neural Cell Adhesion

scholarly journals Ganglioside modulation of neural cell adhesion molecule and N-cadherin-dependent neurite outgrowth

1992 ◽  
Vol 117 (5) ◽  
pp. 1093-1099 ◽  
Author(s):  
P Doherty ◽  
SV Ashton ◽  
SD Skaper ◽  
A Leon ◽  
FS Walsh
Keyword(s):  
Cell Adhesion ◽  
Neurite Outgrowth ◽  
Pc12 Cells ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Neural Cell Adhesion Molecule ◽  
Calcium Influx ◽  
Neural Cell ◽  
3T3 Cells ◽  
Neural Cell Adhesion

We have used monolayers of control 3T3 cells and 3T3 cells expressing transfected human neural cell adhesion molecule (NCAM) or chick N-cadherin as a culture substrate for PC12 cells. NCAM and N-cadherin in the monolayer directly promote neurite outgrowth from PC12 cells via a G-protein-dependent activation of neuronal calcium channels. In the present study we show that ganglioside GM1 does not directly activate this pathway in PC12 cells. However, the presence of GM1 (12.5-100 micrograms/ml) in the co-culture was associated with a potentiation of NCAM and N-cadherin-dependent neurite outgrowth. Treatment of PC12 cells with GM1 (100 micrograms/ml) for 90 min led to trypsin-stable increases in both beta-cholera toxin binding to PC12 cells and an enhanced neurite outgrowth response to N-cadherin. The ganglioside response could be fully inhibited by treatment with pertussis toxin. These data are consistent with exogenous gangliosides enhancing neuritic growth by promoting cell adhesion molecule-induced calcium influx into neurons.

scholarly journals Synergic interaction between amyloid precursor protein and neural cell adhesion molecule promotes neurite outgrowth

Oncotarget ◽  
2016 ◽  
Vol 7 (12) ◽  
pp. 14199-14206 ◽  
Author(s):  
Keping Chen ◽  
Huixia Lu ◽  
Tianli Gao ◽  
Xiulei Xue ◽  
Chunling Wang ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Amyloid Precursor Protein ◽  
Neurite Outgrowth ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Neural Cell Adhesion Molecule ◽  
Neural Cell ◽  
Precursor Protein ◽  
Neural Cell Adhesion

scholarly journals Neural cell adhesion molecule (NCAM) association with PKCβ2 via βI spectrin is implicated in NCAM-mediated neurite outgrowth

2003 ◽  
Vol 161 (3) ◽  
pp. 625-639 ◽  
Author(s):  
Iryna Leshchyns'ka ◽  
Vladimir Sytnyk ◽  
Jon S. Morrow ◽  
Melitta Schachner
Keyword(s):  
Cell Adhesion ◽  
Neurite Outgrowth ◽  
Lipid Rafts ◽  
Adhesion Molecule ◽  
Hippocampal Neurons ◽  
Cell Adhesion Molecule ◽  
Neural Cell Adhesion Molecule ◽  
Neural Cell ◽  
Dominant Negative ◽  
Neural Cell Adhesion

In hippocampal neurons and transfected CHO cells, neural cell adhesion molecule (NCAM) 120, NCAM140, and NCAM180 form Triton X-100–insoluble complexes with βI spectrin. Heteromeric spectrin (αIβI) binds to the intracellular domain of NCAM180, and isolated spectrin subunits bind to both NCAM180 and NCAM140, as does the βI spectrin fragment encompassing second and third spectrin repeats (βI2–3). In NCAM120-transfected cells, βI spectrin is detectable predominantly in lipid rafts. Treatment of cells with methyl-β-cyclodextrin disrupts the NCAM120–spectrin complex, implicating lipid rafts as a platform linking NCAM120 and spectrin. NCAM140/NCAM180–βI spectrin complexes do not depend on raft integrity and are located both in rafts and raft-free membrane domains. PKCβ2 forms detergent-insoluble complexes with NCAM140/NCAM180 and spectrin. Activation of NCAM enhances the formation of NCAM140/NCAM180–spectrin–PKCβ2 complexes and results in their redistribution to lipid rafts. The complex is disrupted by the expression of dominant-negative βI2–3, which impairs binding of spectrin to NCAM, implicating spectrin as the bridge between PKCβ2 and NCAM140 or NCAM180. Redistribution of PKCβ2 to NCAM–spectrin complexes is also blocked by a specific fibroblast growth factor receptor inhibitor. Furthermore, transfection with βI2–3 inhibits NCAM-induced neurite outgrowth, showing that formation of the NCAM–spectrin–PKCβ2 complex is necessary for NCAM-mediated neurite outgrowth.

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