scholarly journals Role of Human DNA Glycosylase Nei-like 2 (NEIL2) and Single Strand Break Repair Protein Polynucleotide Kinase 3′-Phosphatase in Maintenance of Mitochondrial Genome

2011 ◽  
Vol 287 (4) ◽  
pp. 2819-2829 ◽  
Author(s):  
Santi M. Mandal ◽  
Muralidhar L. Hegde ◽  
Arpita Chatterjee ◽  
Pavana M. Hegde ◽  
Bartosz Szczesny ◽  
...  
Keyword(s):  
Mitochondrial Genome ◽  
Strand Break ◽  
Single Strand ◽  
Dna Glycosylase ◽  
Single Strand Break ◽  
Human Dna ◽  
Single Strand Break Repair ◽  
Repair Protein ◽  
Polynucleotide Kinase

scholarly journals XRCC1 Stimulates Human Polynucleotide Kinase Activity at Damaged DNA Termini and Accelerates DNA Single-Strand Break Repair

Cell ◽  
2001 ◽  
Vol 104 (1) ◽  
pp. 107-117 ◽  
Author(s):  
Claire J Whitehouse ◽  
Richard M Taylor ◽  
Angela Thistlethwaite ◽  
Hong Zhang ◽  
Feridoun Karimi-Busheri ◽  
...  
Keyword(s):  
Kinase Activity ◽  
Strand Break ◽  
Single Strand ◽  
Single Strand Break ◽  
Single Strand Break Repair ◽  
Polynucleotide Kinase ◽  
Break Repair ◽  
Damaged Dna

End-damage-specific proteins facilitate recruitment or stability of X-ray cross-complementing protein 1 at the sites of DNA single-strand break repair

FEBS Journal ◽  
2005 ◽  
Vol 272 (22) ◽  
pp. 5753-5763 ◽  
Author(s):  
Jason L. Parsons ◽  
Irina I. Dianova ◽  
Emma Boswell ◽  
Michael Weinfeld ◽  
Grigory L. Dianov
Keyword(s):  
Strand Break ◽  
Single Strand ◽  
Single Strand Break ◽  
X Ray ◽  
Single Strand Break Repair ◽  
Specific Proteins ◽  
Break Repair

Motor Coordination in Space: An Analysis of the Effects of Microgravity on XRCCI DNA Repair Protein Function

2020 ◽  
Author(s):  
Vishruth Nagam
Keyword(s):  
Dna Damage ◽  
Dna Repair ◽  
Protein Function ◽  
Motor Coordination ◽  
Strand Break ◽  
Single Strand Break ◽  
Single Strand Break Repair ◽  
Repair Protein ◽  
Mature Neurons ◽  
Microgravity Conditions

Abstract While in space, astronauts have been known to face exposure to stressors that may increase susceptibility to DNA damage. If DNA repair proteins are defective or nonexistent, DNA mutations may accumulate, causing increasingly abnormal function as one ages [1]. The DNA single-strand break repair protein XRCC1 is important for cerebellar neurogenesis and interneuron development [2]. According to previous studies, a deficiency of XRCC1 can lead to an increase in DNA damage, in mature neurons, and ataxia (a progressive loss of motor coordination) [2]. I propose to address how XRCC1’s efficiency can change in microgravity conditions. This experiment’s relevance is underscored by the importance of motor coordination and physical fitness for astronauts; determining the potential effects of microgravity on XRCC1 is crucial for future space exploration.

scholarly journals Efficient Single-Strand Break Repair Requires Binding to Both Poly(ADP-Ribose) and DNA by the Central BRCT Domain of XRCC1

Cell Reports ◽  
2019 ◽  
Vol 26 (3) ◽  
pp. 573-581.e5 ◽  
Author(s):  
Luis M. Polo ◽  
Yingqi Xu ◽  
Peter Hornyak ◽  
Fernando Garces ◽  
Zhihong Zeng ◽  
...  
Keyword(s):  
Strand Break ◽  
Single Strand ◽  
Brct Domain ◽  
Single Strand Break ◽  
Single Strand Break Repair ◽  
Break Repair

scholarly journals TDP1 facilitates chromosomal single-strand break repair in neurons and is neuroprotective in vivo

2007 ◽  
Vol 26 (22) ◽  
pp. 4720-4731 ◽  
Author(s):  
Sachin Katyal ◽  
Sherif F El-Khamisy ◽  
Helen R Russell ◽  
Yang Li ◽  
Limei Ju ◽  
...  
Keyword(s):  
Strand Break ◽  
Single Strand ◽  
Single Strand Break ◽  
Single Strand Break Repair ◽  
Break Repair
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