scholarly journals Proliferating Cell Nuclear Antigen (PCNA)-binding Protein C1orf124 Is a Regulator of Translesion Synthesis

2012 ◽  
Vol 287 (41) ◽  
pp. 34225-34233 ◽  
Author(s):  
Gargi Ghosal ◽  
Justin Wai-Chung Leung ◽  
Binoj C. Nair ◽  
Ka-Wing Fong ◽  
Junjie Chen
Keyword(s):  
Proliferating Cell Nuclear Antigen ◽  
Binding Protein ◽  
Translesion Synthesis ◽  
Nuclear Antigen ◽  
Proliferating Cell

scholarly journals Structural Basis for Novel Interactions between Human Translesion Synthesis Polymerases and Proliferating Cell Nuclear Antigen

2009 ◽  
Vol 284 (16) ◽  
pp. 10552-10560 ◽  
Author(s):  
Asami Hishiki ◽  
Hiroshi Hashimoto ◽  
Tomo Hanafusa ◽  
Keijiro Kamei ◽  
Eiji Ohashi ◽  
...  
Keyword(s):  
Proliferating Cell Nuclear Antigen ◽  
Translesion Synthesis ◽  
Nuclear Antigen ◽  
Structural Basis ◽  
Novel Interactions ◽  
Proliferating Cell

scholarly journals The Hepatitis B Virus X Protein Functionally Interacts with CREB-binding Protein/p300 in the Regulation of CREB-mediated Transcription

2006 ◽  
Vol 282 (7) ◽  
pp. 4277-4287 ◽  
Author(s):  
Delphine Cougot ◽  
Yuanfei Wu ◽  
Stefano Cairo ◽  
Julie Caramel ◽  
Claire-Angélique Renard ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Proliferating Cell Nuclear Antigen ◽  
Binding Protein ◽  
Interleukin 8 ◽  
Nuclear Antigen ◽  
Creb Binding Protein ◽  
X Protein ◽  
B Virus ◽  
Proliferating Cell

The hepatitis B virus infects more than 350 million people worldwide and is a leading cause of liver cancer. The virus encodes a multifunctional regulator, the hepatitis B virus X protein (HBx), that is essential for virus replication. HBx is involved in modulating signal transduction pathways and transcription mediated by various factors, notably CREB that requires the recruitment of the co-activators CREB-binding protein (CBP)/p300. Here we investigated the role of HBx and its potential interaction with CBP/p300 in regulating CREB transcriptional activity. We show that HBx and CBP/p300 synergistically enhanced CREB activity and that CREB phosphorylation by protein kinase A was a prerequisite for the cooperative action of HBx and CBP/p300. We further show that HBx interacted directly with CBP/p300 in vitro and in vivo. Using chromatin immunoprecipitation, we provide evidence that HBx physically occupied the CREB-binding domain of CREB-responsive promoters of endogenous cellular genes such as interleukin 8 and proliferating cell nuclear antigen. Moreover expression of HBx increased the recruitment of p300 to the interleukin 8 and proliferating cell nuclear antigen promoters in cells, and this is associated with increased gene expression. As recruitment of CBP/p300 is known to represent the limiting event for activating CREB target genes, HBx may disrupt this cellular regulation, thus predisposing cells to transformation.

Interaction between proliferating cell nuclear antigen and JUN-activation-domain-binding protein 1 in the meristem of rice, Oryza sativa L.

Planta ◽  
2003 ◽  
Vol 217 (2) ◽  
pp. 175-183 ◽  
Author(s):  
Taichi Yamamoto ◽  
Seisuke Kimura ◽  
Yoko Mori ◽  
Yukinobu Uchiyama ◽  
Toyotaka Ishibashi ◽  
...  
Keyword(s):  
Oryza Sativa ◽  
Proliferating Cell Nuclear Antigen ◽  
Oryza Sativa L ◽  
Binding Protein ◽  
Nuclear Antigen ◽  
Activation Domain ◽  
Proliferating Cell
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