Mechanism by Which Fatty Acids Inhibit Insulin Activation of Insulin Receptor Substrate-1 (IRS-1)-associated Phosphatidylinositol 3-Kinase Activity in Muscle

Journal of Biological Chemistry ◽

10.1074/jbc.m200958200 ◽

2002 ◽

Vol 277 (52) ◽

pp. 50230-50236 ◽

Cited By ~ 1024

Author(s):

Chunli Yu ◽

Yan Chen ◽

Gary W. Cline ◽

Dongyan Zhang ◽

Haihong Zong ◽

...

Keyword(s):

Fatty Acids ◽

Insulin Receptor ◽

Kinase Activity ◽

Insulin Receptor Substrate ◽

Phosphatidylinositol 3 Kinase ◽

Insulin Receptor Substrate 1 ◽

Phosphatidylinositol 3

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Insulin Receptor Substrate-1 Phosphorylation and Phosphatidylinositol 3-Kinase Activity in Skeletal Muscle From NIDDM Subjects After In Vivo Insulin Stimulation

Diabetes ◽

10.2337/diab.46.3.524 ◽

1997 ◽

Vol 46 (3) ◽

pp. 524-527 ◽

Author(s):

M. Bjornholm ◽

Y. Kawano ◽

M. Lehtihet ◽

J. R. Zierath

Keyword(s):

Skeletal Muscle ◽

Insulin Receptor ◽

Kinase Activity ◽

Insulin Receptor Substrate ◽

Phosphatidylinositol 3 Kinase ◽

Insulin Stimulation ◽

Insulin Receptor Substrate 1 ◽

Phosphatidylinositol 3

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14-3-3β Protein Associates with Insulin Receptor Substrate 1 and Decreases Insulin-stimulated Phosphatidylinositol 3′-Kinase Activity in 3T3L1 Adipocytes

Journal of Biological Chemistry ◽

10.1074/jbc.273.2.940 ◽

1998 ◽

Vol 273 (2) ◽

pp. 940-944 ◽

Author(s):

Atsushi Kosaki ◽

Kazunori Yamada ◽

Junko Suga ◽

Akira Otaka ◽

Hideshi Kuzuya

Keyword(s):

Insulin Receptor ◽

Kinase Activity ◽

Insulin Receptor Substrate ◽

Phosphatidylinositol 3 Kinase ◽

Insulin Receptor Substrate 1 ◽

Phosphatidylinositol 3

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Insulin stimulation of phosphatidylinositol 3-kinase activity and association with insulin receptor substrate 1 in liver and muscle of the intact rat.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(18)41650-x ◽

1992 ◽

Vol 267 (31) ◽

pp. 22171-22177 ◽

Author(s):

F Folli ◽

M.J. Saad ◽

J.M. Backer ◽

C.R. Kahn

Keyword(s):

Insulin Receptor ◽

Kinase Activity ◽

Insulin Receptor Substrate ◽

Phosphatidylinositol 3 Kinase ◽

Insulin Stimulation ◽

Insulin Receptor Substrate 1 ◽

Stimulation Of ◽

Phosphatidylinositol 3

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Insulin receptor phosphorylation, insulin receptor substrate-1 phosphorylation, and phosphatidylinositol 3-kinase activity are decreased in intact skeletal muscle strips from obese subjects.

Journal of Clinical Investigation ◽

10.1172/jci117909 ◽

1995 ◽

Vol 95 (5) ◽

pp. 2195-2204 ◽

Author(s):

L J Goodyear ◽

F Giorgino ◽

L A Sherman ◽

J Carey ◽

R J Smith ◽

...

Keyword(s):

Skeletal Muscle ◽

Insulin Receptor ◽

Kinase Activity ◽

Insulin Receptor Substrate ◽

Phosphatidylinositol 3 Kinase ◽

Insulin Receptor Substrate 1 ◽

Receptor Phosphorylation ◽

Obese Subjects ◽

Phosphatidylinositol 3

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Tyr612 and Tyr632 in Human Insulin Receptor Substrate-1 Are Important for Full Activation of Insulin-Stimulated Phosphatidylinositol 3-Kinase Activity and Translocation of GLUT4 in Adipose Cells*

Endocrinology ◽

10.1210/endo.142.7.8283 ◽

2001 ◽

Vol 142 (7) ◽

pp. 2833-2840 ◽

Author(s):

Diana L. Esposito ◽

Yunhua Li ◽

Alessandro Cama ◽

Michael J. Quon

Keyword(s):

Insulin Receptor ◽

Human Insulin ◽

Kinase Activity ◽

Insulin Receptor Substrate ◽

Phosphatidylinositol 3 Kinase ◽

Insulin Receptor Substrate 1 ◽

Human Insulin Receptor ◽

Adipose Cells ◽

Full Activation ◽

Phosphatidylinositol 3

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Expression of Dominant Negative Mutant SHPTP2 Attenuates Phosphatidylinositol 3′-Kinase Activity via Modulation of Phosphorylation of Insulin Receptor Substrate-1

Journal of Biological Chemistry ◽

10.1074/jbc.271.21.12595 ◽

1996 ◽

Vol 271 (21) ◽

pp. 12595-12602 ◽

Author(s):

Satoshi Ugi ◽

Hiroshi Maegawa ◽

Atsunori Kashiwagi ◽

Masaaki Adachi ◽

Jerrold M. Olefsky ◽

...

Keyword(s):

Insulin Receptor ◽

Kinase Activity ◽

Dominant Negative ◽

Dominant Negative Mutant ◽

Insulin Receptor Substrate ◽

Phosphatidylinositol 3 Kinase ◽

Insulin Receptor Substrate 1 ◽

Negative Mutant ◽

Phosphatidylinositol 3

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Insulin receptor substrate-1 phosphorylation and phosphatidylinositol 3-kinase activity in skeletal muscle from NIDDM subjects after in vivo insulin stimulation

Diabetes ◽

10.2337/diabetes.46.3.524 ◽

1997 ◽

Vol 46 (3) ◽

pp. 524-527 ◽

Author(s):

M. Bjornholm ◽

Y. Kawano ◽

M. Lehtihet ◽

J. R. Zierath

Keyword(s):

Skeletal Muscle ◽

Insulin Receptor ◽

Kinase Activity ◽

Insulin Receptor Substrate ◽

Phosphatidylinositol 3 Kinase ◽

Insulin Stimulation ◽

Insulin Receptor Substrate 1 ◽

Phosphatidylinositol 3

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Persistent Activation of Phosphatidylinositol 3-Kinase Causes Insulin Resistance Due to Accelerated Insulin-Induced Insulin Receptor Substrate-1 Degradation in 3T3-L1 Adipocytes*

Endocrinology ◽

10.1210/endo.141.6.7516 ◽

2000 ◽

Vol 141 (6) ◽

pp. 1930-1935 ◽

Author(s):

Katsuya Egawa ◽

Naoki Nakashima ◽

Prem M. Sharma ◽

Hiroshi Maegawa ◽

Yoshio Nagai ◽

...

Keyword(s):

Insulin Resistance ◽

Insulin Receptor ◽

Insulin Receptor Substrate ◽

Phosphatidylinositol 3 Kinase ◽

Insulin Receptor Substrate 1 ◽

Phosphatidylinositol 3

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Platelet-derived Growth Factor Inhibits Insulin Stimulation of Insulin Receptor Substrate-1-associated Phosphatidylinositol 3-Kinase in 3T3-L1 Adipocytes without Affecting Glucose Transport

Journal of Biological Chemistry ◽

10.1074/jbc.273.39.25139 ◽

1998 ◽

Vol 273 (39) ◽

pp. 25139-25147 ◽

Author(s):

Patricia A. Staubs ◽

James G. Nelson ◽

Donna R. Reichart ◽

Jerrold M. Olefsky

Keyword(s):

Growth Factor ◽

Insulin Receptor ◽

Glucose Transport ◽

Platelet Derived Growth Factor ◽

Insulin Receptor Substrate ◽

Phosphatidylinositol 3 Kinase ◽

Insulin Stimulation ◽

Insulin Receptor Substrate 1 ◽

Stimulation Of ◽

Phosphatidylinositol 3

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Insulin-induced egr-1 and c-fos expression in 32D cells requires insulin receptor, Shc, and mitogen-activated protein kinase, but not insulin receptor substrate-1 and phosphatidylinositol 3-kinase activation.

Journal of Biological Chemistry ◽

10.1074/s0021-9258(19)67421-1 ◽

2001 ◽

Vol 272 (5) ◽

pp. 3124

Author(s):

Shuko Harada ◽

Robert M. Smith ◽

Judith A. Smith ◽

Morris F. White ◽

Leonard Jarett

Keyword(s):

Protein Kinase ◽

Insulin Receptor ◽

Mitogen Activated Protein Kinase ◽

Insulin Receptor Substrate ◽

Phosphatidylinositol 3 Kinase ◽

Insulin Receptor Substrate 1 ◽

Kinase Activation ◽

Mitogen Activated Protein ◽

Fos Expression ◽

Phosphatidylinositol 3

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