The Low Density Lipoprotein Receptor-related Protein Is a Motogenic Receptor for Plasminogen Activator Inhibitor-1

Bernard Degryse; Jaap G. Neels; Ralf-Peter Czekay; Kathleen Aertgeerts; Yu-ichi Kamikubo; David J. Loskutoff

doi:10.1074/jbc.m313004200

The Low Density Lipoprotein Receptor-related Protein Is a Motogenic Receptor for Plasminogen Activator Inhibitor-1

Journal of Biological Chemistry ◽

10.1074/jbc.m313004200 ◽

2004 ◽

Vol 279 (21) ◽

pp. 22595-22604 ◽

Cited By ~ 125

Author(s):

Bernard Degryse ◽

Jaap G. Neels ◽

Ralf-Peter Czekay ◽

Kathleen Aertgeerts ◽

Yu-ichi Kamikubo ◽

...

Keyword(s):

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Plasminogen Activator Inhibitor ◽

Low Density ◽

Lipoprotein Receptor ◽

Related Protein ◽

Plasminogen Activator Inhibitor 1 ◽

Density Lipoprotein Receptor ◽

Lipoprotein Receptor Related Protein ◽

Activator Inhibitor

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Plasma plasminogen activator inhibitor-1 level is not regulated by the hepatic low-density lipoprotein receptor-related protein

Journal of Thrombosis and Haemostasis ◽

10.1111/j.1538-7836.2007.02733.x ◽

2007 ◽

Vol 5 (11) ◽

pp. 2301-2304

Author(s):

L. HU ◽

N. BOVENSCHEN ◽

L. M. HAVEKES ◽

B. J. M. VAN VLIJMEN ◽

J. T. TAMSMA

Keyword(s):

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Plasminogen Activator Inhibitor ◽

Low Density ◽

Lipoprotein Receptor ◽

Related Protein ◽

Plasminogen Activator Inhibitor 1 ◽

Density Lipoprotein Receptor ◽

Lipoprotein Receptor Related Protein ◽

Activator Inhibitor

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Low density lipoprotein receptor-related protein and gp330 bind similar ligands, including plasminogen activator-inhibitor complexes and lactoferrin, an inhibitor of chylomicron remnant clearance.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(18)35732-6 ◽

1992 ◽

Vol 267 (36) ◽

pp. 26172-26180 ◽

Cited By ~ 25

Author(s):

T.E. Willnow ◽

J.L. Goldstein ◽

K Orth ◽

M.S. Brown ◽

J Herz

Keyword(s):

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Plasminogen Activator Inhibitor ◽

Low Density ◽

Lipoprotein Receptor ◽

Chylomicron Remnant ◽

Related Protein ◽

Density Lipoprotein Receptor ◽

Lipoprotein Receptor Related Protein ◽

Activator Inhibitor

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Vitronectin inhibits plasminogen activator inhibitor-1-induced signalling and chemotaxis by blocking plasminogen activator inhibitor-1 binding to the low-density lipoprotein receptor-related protein

The International Journal of Biochemistry & Cell Biology ◽

10.1016/j.biocel.2008.07.006 ◽

2009 ◽

Vol 41 (3) ◽

pp. 578-585 ◽

Cited By ~ 24

Author(s):

Yuichi Kamikubo ◽

Jaap G. Neels ◽

Bernard Degryse

Keyword(s):

Plasminogen Activator ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Plasminogen Activator Inhibitor ◽

Lipoprotein Receptor ◽

Related Protein ◽

Plasminogen Activator Inhibitor 1 ◽

Density Lipoprotein Receptor ◽

Lipoprotein Receptor Related Protein ◽

Activator Inhibitor

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Clearance of plasminogen activator inhibitor-1 in low-density lipoprotein receptor-related protein deficient mice

Vascular Pharmacology ◽

10.1016/j.vph.2006.08.388 ◽

2006 ◽

Vol 45 (3) ◽

pp. e149

Author(s):

Lihui Hu ◽

Bart J.M. van Vlijmen ◽

Niels Bovenschen ◽

Menno V. Huisman ◽

Louis M. Havekes ◽

...

Keyword(s):

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Plasminogen Activator Inhibitor ◽

Lipoprotein Receptor ◽

Related Protein ◽

Plasminogen Activator Inhibitor 1 ◽

Density Lipoprotein Receptor ◽

Lipoprotein Receptor Related Protein ◽

Deficient Mice ◽

Activator Inhibitor

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Analysis of the Binding of Pro-urokinase and Urokinase-Plasminogen Activator Inhibitor-1 Complex to the Low Density Lipoprotein Receptor-related Protein Using a Fab Fragment Selected from a Phage-displayed Fab Library

Journal of Biological Chemistry ◽

10.1074/jbc.270.20.11770 ◽

1995 ◽

Vol 270 (20) ◽

pp. 11770-11775 ◽

Cited By ~ 16

Author(s):

Ivo R. Horn ◽

SK. Moestrup ◽

Birgit M. M. van den Berg ◽

Hans Pannekoek ◽

Morten S. Nielsen ◽

...

Keyword(s):

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Plasminogen Activator Inhibitor ◽

Lipoprotein Receptor ◽

Related Protein ◽

Plasminogen Activator Inhibitor 1 ◽

Fab Fragment ◽

Density Lipoprotein Receptor ◽

Lipoprotein Receptor Related Protein ◽

Activator Inhibitor

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Specificity of Binding of the Low Density Lipoprotein Receptor-related Protein to Different Conformational States of the Clade E Serpins Plasminogen Activator Inhibitor-1 and Proteinase Nexin-1

Journal of Biological Chemistry ◽

10.1074/jbc.m109.009530 ◽

2009 ◽

Vol 284 (27) ◽

pp. 17989-17997 ◽

Cited By ~ 22

Author(s):

Jan K. Jensen ◽

Klavs Dolmer ◽

Peter G. W. Gettins

Keyword(s):

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Plasminogen Activator Inhibitor ◽

Lipoprotein Receptor ◽

Related Protein ◽

Plasminogen Activator Inhibitor 1 ◽

Density Lipoprotein Receptor ◽

Specificity Of Binding ◽

Lipoprotein Receptor Related Protein ◽

Activator Inhibitor

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Plasminogen Activator Inhibitor-1 Contains a Cryptic High Affinity Binding Site for the Low Density Lipoprotein Receptor-related Protein

Journal of Biological Chemistry ◽

10.1074/jbc.273.11.6358 ◽

1998 ◽

Vol 273 (11) ◽

pp. 6358-6366 ◽

Cited By ~ 97

Author(s):

Steingrimur Stefansson ◽

Shabazz Muhammad ◽

Xiang-Fei Cheng ◽

Frances D. Battey ◽

Dudley K. Strickland ◽

...

Keyword(s):

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Plasminogen Activator Inhibitor ◽

Lipoprotein Receptor ◽

Related Protein ◽

Plasminogen Activator Inhibitor 1 ◽

High Affinity Binding Site ◽

Density Lipoprotein Receptor ◽

Lipoprotein Receptor Related Protein ◽

Activator Inhibitor

Download Full-text

The High Affinity Binding Site on Plasminogen Activator Inhibitor-1 (PAI-1) for the Low Density Lipoprotein Receptor-related Protein (LRP1) Is Composed of Four Basic Residues

Journal of Biological Chemistry ◽

10.1074/jbc.m115.688820 ◽

2015 ◽

Vol 291 (2) ◽

pp. 800-812 ◽

Cited By ~ 7

Author(s):

Peter G. W. Gettins ◽

Klavs Dolmer

Keyword(s):

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Plasminogen Activator Inhibitor ◽

Lipoprotein Receptor ◽

Plasminogen Activator Inhibitor 1 ◽

High Affinity Binding Site ◽

Density Lipoprotein Receptor ◽

Lipoprotein Receptor Related Protein ◽

Activator Inhibitor ◽

Pai 1

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Plasminogen Activator Inhibitor-1 and Vitronectin Promote the Cellular Clearance of Thrombin by Low Density Lipoprotein Receptor-related Proteins 1 and 2

Journal of Biological Chemistry ◽

10.1074/jbc.271.14.8215 ◽

1996 ◽

Vol 271 (14) ◽

pp. 8215-8220 ◽

Cited By ~ 45

Author(s):

Steingrimur Stefansson ◽

Daniel A. Lawrence ◽

W. Scott Argraves

Keyword(s):

Plasminogen Activator ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Plasminogen Activator Inhibitor ◽

Low Density ◽

Lipoprotein Receptor ◽

Plasminogen Activator Inhibitor 1 ◽

Density Lipoprotein Receptor ◽

Related Proteins ◽

Activator Inhibitor

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132 Plasminogen activator inhibitor-1 (PAI-1) a molecular switch that contains a cryptic high affinity binding site for the low density lipoprotein receptor related protein (LRP)

Fibrinolysis and Proteolysis ◽

10.1016/s0268-9499(97)80248-2 ◽

1997 ◽

Vol 11 ◽

pp. 37

Author(s):

S. Stefansson ◽

S. Muhammad ◽

F.D. Battey ◽

D.K. Strickland ◽

D.A. Lawrence

Keyword(s):

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Plasminogen Activator Inhibitor ◽

Lipoprotein Receptor ◽

Plasminogen Activator Inhibitor 1 ◽

High Affinity Binding Site ◽

Density Lipoprotein Receptor ◽

Lipoprotein Receptor Related Protein ◽

Activator Inhibitor ◽

Pai 1

Download Full-text