scholarly journals Actions Downstream of Cyclic GMP/Protein Kinase G Can Reverse Protein Kinase C-mediated Phosphorylation of CPI-17 and Ca2+Sensitization in Smooth Muscle

2004 ◽  
Vol 279 (28) ◽  
pp. 28998-29003 ◽  
Author(s):  
Johan Bonnevier ◽  
Anders Arner
Keyword(s):  
Smooth Muscle ◽  
Protein Kinase C ◽  
Protein Kinase ◽  
Cyclic Gmp ◽  
Protein Kinase G ◽  
Kinase C

Cyclic GMP and protein kinase G inhibit the quantal transmitter release induced by protein kinase C

1988 ◽  
Vol 4 (3) ◽  
pp. 263-266 ◽  
Author(s):  
Dimitrie D. Brǎnişteanu ◽  
Laurenţiu M. Popescu ◽  
Dumitru D. Brǎnişteanu ◽  
Ion D. Haulicǎ
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Cyclic Gmp ◽  
Transmitter Release ◽  
Protein Kinase G ◽  
Kinase C ◽  
Quantal Transmitter Release

scholarly journals An activator of protein kinase C (phorbol dibutyrate) attenuates atrial-natriuretic-factor-stimulated cyclic GMP accumulation in smooth-muscle cells

1987 ◽  
Vol 244 (2) ◽  
pp. 481-484 ◽  
Author(s):  
P Nambi ◽  
M Whitman ◽  
N Aiyar ◽  
F Stassen ◽  
S T Crooke
Keyword(s):  
Smooth Muscle ◽  
Protein Kinase C ◽  
Protein Kinase ◽  
Smooth Muscle Cells ◽  
Cyclic Gmp ◽  
Atrial Natriuretic Factor ◽  
Muscle Cells ◽  
Phorbol Dibutyrate ◽  
Kinase C ◽  
Natriuretic Factor

Rat thoracic aortic smooth-muscle cells (A-10; A.T.C.C. CRL 1476) displays a high density of vasopressin and atrial-natriuretic-factor (ANF) receptors and a low density of beta-adrenergic receptors. ANF stimulates cGMP (cyclic GMP) accumulation in a time- and dose-dependent fashion. Pretreatment of these cells with phorbol dibutyrate (PDBu), a known activator of protein kinase C, attenuated ANF-stimulated cGMP accumulation without affecting basal cGMP concentrations. This effect was concentration-dependent and was observed as early as 2 min after treatment. 4 alpha-Phorbol 12, 13-didecanoate (alpha PDD), which does not activate protein kinase C, did not inhibit the cGMP accumulation. PDBu pretreatment did not affect the density and affinity of ANF receptors. These data suggest that PDBu, presumably via activation of protein kinase C, might stimulate phosphorylation of a key regulatory protein in the ANF/cGMP pathway.

Regulation of Scavenger Receptor Expression in Smooth Muscle Cells by Protein Kinase C

1997 ◽  
Vol 17 (5) ◽  
pp. 969-978 ◽  
Author(s):  
Michele Mietus-Snyder ◽  
Annabelle Friera ◽  
Christopher K. Glass ◽  
Robert E. Pitas
Keyword(s):  
Smooth Muscle ◽  
Protein Kinase C ◽  
Protein Kinase ◽  
Smooth Muscle Cells ◽  
Scavenger Receptor ◽  
Muscle Cells ◽  
Receptor Expression ◽  
Kinase C

Antiproliferative action of protein kinase C in cultured rabbit aortic smooth muscle cells

1987 ◽  
Vol 173 (2) ◽  
pp. 504-514 ◽  
Author(s):  
Ken-Ichi Kariya ◽  
Yasuo Fukumoto ◽  
Terutaka Tsuda ◽  
Takeshi Yamamoto ◽  
Yasuhiro Kawahara ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Protein Kinase C ◽  
Protein Kinase ◽  
Smooth Muscle Cells ◽  
Muscle Cells ◽  
Aortic Smooth Muscle Cells ◽  
Aortic Smooth Muscle ◽  
Kinase C ◽  
Antiproliferative Action
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