scholarly journals Role of Tom5 in Maintaining the Structural Stability of the TOM Complex of Mitochondria

2005 ◽  
Vol 280 (15) ◽  
pp. 14499-14506 ◽  
Author(s):  
Simone Schmitt ◽  
Uwe Ahting ◽  
Lutz Eichacker ◽  
Bernhard Granvogl ◽  
Nancy E. Go ◽  
...  
2021 ◽  
Vol 866 ◽  
pp. 158982
Author(s):  
Sourabh Wajhal ◽  
S.K. Mishra ◽  
A.B. Shinde ◽  
P.S.R. Krishna ◽  
R. Mittal

2013 ◽  
Vol 288 (23) ◽  
pp. 16451-16459 ◽  
Author(s):  
Thomas Becker ◽  
Susanne E. Horvath ◽  
Lena Böttinger ◽  
Natalia Gebert ◽  
Günther Daum ◽  
...  

The mitochondrial outer membrane contains proteinaceous machineries for the import and assembly of proteins, including TOM (translocase of the outer membrane) and SAM (sorting and assembly machinery). It has been shown that the dimeric phospholipid cardiolipin is required for the stability of TOM and SAM complexes and thus for the efficient import and assembly of β-barrel proteins and some α-helical proteins of the outer membrane. Here, we report that mitochondria deficient in phosphatidylethanolamine (PE), the second non-bilayer-forming phospholipid, are impaired in the biogenesis of β-barrel proteins, but not of α-helical outer membrane proteins. The stability of TOM and SAM complexes is not disturbed by the lack of PE. By dissecting the import steps of β-barrel proteins, we show that an early import stage involving translocation through the TOM complex is affected. In PE-depleted mitochondria, the TOM complex binds precursor proteins with reduced efficiency. We conclude that PE is required for the proper function of the TOM complex.


Geoderma ◽  
2001 ◽  
Vol 101 (3-4) ◽  
pp. 15-30 ◽  
Author(s):  
O Malam Issa ◽  
Y Le Bissonnais ◽  
C Défarge ◽  
J Trichet

2020 ◽  
Vol 12 (25) ◽  
pp. 28416-28425 ◽  
Author(s):  
Adara Babuji ◽  
Inés Temiño ◽  
Ana Pérez-Rodríguez ◽  
Olga Solomeshch ◽  
Nir Tessler ◽  
...  

2020 ◽  
Vol 118 (3) ◽  
pp. 181a-182a
Author(s):  
Christine Dunham ◽  
Eric D. Hoffer ◽  
Ha An Nguyen ◽  
Sunita Subramanian ◽  
Samuel Hong ◽  
...  

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