scholarly journals Coordinated Activation of the Origin Licensing Factor CDC6 and CDK2 in Resting Human Fibroblasts Expressing SV40 Small T Antigen and Cyclin E

2009 ◽  
Vol 284 (21) ◽  
pp. 14126-14135 ◽  
Author(s):  
Elena Sotillo ◽  
Judit Garriga ◽  
Amol Padgaonkar ◽  
Alison Kurimchak ◽  
Jeanette Gowen Cook ◽  
...  
Keyword(s):  
Cyclin E ◽  
Human Fibroblasts ◽  
T Antigen ◽  
Origin Licensing ◽  
Licensing Factor ◽  
Small T Antigen ◽  
Sv40 Small T

scholarly journals Cyclin E and SV40 Small t Antigen Cooperate to Bypass Quiescence and Contribute to Transformation by Activating CDK2 in Human Fibroblasts

2008 ◽  
Vol 283 (17) ◽  
pp. 11280-11292 ◽  
Author(s):  
Elena Sotillo ◽  
Judit Garriga ◽  
Alison Kurimchak ◽  
Xavier Graña
Keyword(s):  
Cyclin E ◽  
Human Fibroblasts ◽  
T Antigen ◽  
Small T Antigen ◽  
Sv40 Small T

scholarly journals Overexpression of Simian Virus 40 Small-T Antigen Blocks Centrosome Function and Mitotic Progression in Human Fibroblasts

2001 ◽  
Vol 75 (20) ◽  
pp. 9799-9807 ◽  
Author(s):  
Stéphanie Gaillard ◽  
Kelly M. Fahrbach ◽  
Rajini Parkati ◽  
Kathleen Rundell
Keyword(s):  
Cell Cycle ◽  
Human Fibroblasts ◽  
Simian Virus 40 ◽  
Simian Virus ◽  
T Antigen ◽  
Human Diploid Fibroblasts ◽  
Biochemical Status ◽  
Phosphatase 2A ◽  
Small T Antigen ◽  
Sv40 Small T

ABSTRACT Recombinant adenoviruses that express high levels of the simian virus 40 (SV40) small-t (ST) antigen have been used to study the requirement for ST to drive cell cycle proliferation of confluent human diploid fibroblasts. This occurs when either large-T (LT) antigen or serum is added to provide a second signal. While cells readily completed S phase in these experiments, they were found to accumulate with 4N DNA content. Cellular and nuclear morphology, as well as the biochemical status of cyclin B complexes, showed that these cells entered mitosis but were blocked prior to mitotic metaphase. The defect appears to reflect an inability of cells overexpressing ST to form organized centrosomes that duplicate and separate normally during the cell cycle and, therefore, the absence of a mitotic spindle. The ability of ST to bind protein phosphatase 2A was required for this pattern, suggesting that altered phosphorylation of key centrosomal components may occur when ST is overexpressed. Although the possible significance of ST effects on the centrosome cycle is not fully understood, these findings suggest that ST could influence chromosomal instability patterns that are a hallmark of SV40-transformed cells and LT expression.

The SV40 small t antigen is essential for the morphological transformation of human fibroblasts

Virology ◽  
1989 ◽  
Vol 171 (1) ◽  
pp. 260-263 ◽  
Author(s):  
A. De Ronde ◽  
C.J.A. Sol ◽  
A. Van Strien ◽  
J. Ter Schegget ◽  
J. Van Der Noordaa
Keyword(s):  
Human Fibroblasts ◽  
T Antigen ◽  
Morphological Transformation ◽  
Small T Antigen ◽  
Sv40 Small T

SV40 small t antigen enhances the transformation activity of limiting concentrations of SV40 large T antigen

Cell ◽  
1987 ◽  
Vol 48 (2) ◽  
pp. 321-330 ◽  
Author(s):  
Ilan Bikel ◽  
Ximena Montano ◽  
Mounzer E. Agha ◽  
Myles Brown ◽  
Melissa McCormack ◽  
...  
Keyword(s):  
T Antigen ◽  
Large T Antigen ◽  
Sv40 Large T Antigen ◽  
Transformation Activity ◽  
Small T Antigen ◽  
Sv40 Small T

A fail-safe system to prevent oncogenesis by senescence is targeted by SV40 small T antigen

Oncogene ◽  
2019 ◽  
Vol 39 (10) ◽  
pp. 2170-2186 ◽  
Author(s):  
Kiyotaka Oshikawa ◽  
Masaki Matsumoto ◽  
Manabu Kodama ◽  
Hideyuki Shimizu ◽  
Keiichi I. Nakayama
Keyword(s):  
T Antigen ◽  
Small T Antigen ◽  
Fail Safe ◽  
Sv40 Small T

SV40 Small T Antigen Enhances Progression to >G2 during Lytic Infection

1999 ◽  
Vol 251 (1) ◽  
pp. 121-127 ◽  
Author(s):  
Brian Whalen ◽  
Judith Laffin ◽  
Thomas D. Friedrich ◽  
John M. Lehman
Keyword(s):  
T Antigen ◽  
Lytic Infection ◽  
Small T Antigen ◽  
Sv40 Small T

Hepatic Expression of SV40 Small-t Antigen Blocks the in Vivo CD95-Mediated Apoptosis

2001 ◽  
Vol 284 (2) ◽  
pp. 369-376 ◽  
Author(s):  
Raphaëlle Gillet ◽  
Catherine Cavard ◽  
Gisèle Grimber ◽  
Pascale Briand ◽  
Virginie Joulin
Keyword(s):  
T Antigen ◽  
Hepatic Expression ◽  
Small T Antigen ◽  
Sv40 Small T
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