Antigenicity and Predefined Specificities of the Multi-Epitope Vaccine in Candidate Consisting of Neutralizing Epitope and Mutated Epitopes Suggested a New Way against HIV-1 Mutation

Immunobiology ◽  
2001 ◽  
Vol 204 (4) ◽  
pp. 434-441 ◽  
Author(s):  
H TIAN
Keyword(s):  
Neutralizing Epitope ◽  
Epitope Vaccine ◽  
Hiv 1

scholarly journals Human immunodeficiency virus 1. Predominance of a group-specific neutralizing epitope that persists despite genetic variation.

1989 ◽  
Vol 170 (5) ◽  
pp. 1681-1695 ◽  
Author(s):  
I Berkower ◽  
G E Smith ◽  
C Giri ◽  
D Murphy
Keyword(s):  
Genetic Diversity ◽  
Human Immunodeficiency Virus ◽  
Neutralizing Antibodies ◽  
Neutralizing Epitope ◽  
Vaccine Strategy ◽  
Disease Pathogenesis ◽  
Immunodeficiency Virus ◽  
High Degree ◽  
Hiv 1 ◽  
Human Immunodeficiency Virus 1

HIV-1 is known to show a high degree of genetic diversity, which may have major implications for disease pathogenesis and prevention. If every divergent isolate represented a distinct serotype, then effective vaccination might be impossible. However, using a sensitive new plaque-forming assay for HIV-1, we have found that most infected patients make neutralizing antibodies, predominantly to a group-specific epitope shared among three highly divergent isolates. This epitope persists among divergent isolates and rarely mutates, despite the rapid overall mutation rate of HIV-1, suggesting that it may participate in an essential viral function. These findings, plus the rarity of reinfections among these patients, suggest that HIV-1 may be more susceptible to a vaccine strategy based on a group-specific neutralizing epitope than was previously suspected.

scholarly journals Loss of a neutralizing epitope by a spontaneous point mutation in the V3 loop of HIV-1 isolated from an infected laboratory worker.

1993 ◽  
Vol 268 (34) ◽  
pp. 25894-25901
Author(s):  
F di Marzo Veronese ◽  
M S Reitz ◽  
G Gupta ◽  
M Robert-Guroff ◽  
C Boyer-Thompson ◽  
...  
Keyword(s):  
Point Mutation ◽  
V3 Loop ◽  
Neutralizing Epitope ◽  
Laboratory Worker ◽  
Hiv 1

scholarly journals Focusing the immune response on the V3 loop, a neutralizing epitope of the HIV-1 gp120 envelope

Virology ◽  
2008 ◽  
Vol 372 (2) ◽  
pp. 233-246 ◽  
Author(s):  
Susan Zolla-Pazner ◽  
Sandra Sharpe Cohen ◽  
Chavdar Krachmarov ◽  
Shixia Wang ◽  
Abraham Pinter ◽  
...  
Keyword(s):  
Immune Response ◽  
V3 Loop ◽  
Neutralizing Epitope ◽  
Gp120 Envelope ◽  
Hiv 1

scholarly journals The Caveolin-1 Binding Domain of HIV-1 Glycoprotein gp41 Is an Efficient B Cell Epitope Vaccine Candidate against Virus Infection

Immunity ◽  
2004 ◽  
Vol 21 (5) ◽  
pp. 617-627 ◽  
Author(s):  
Ara G. Hovanessian ◽  
Jean-Paul Briand ◽  
Elias A. Said ◽  
Josette Svab ◽  
Stephane Ferris ◽  
...  
Keyword(s):  
Virus Infection ◽  
B Cell ◽  
Vaccine Candidate ◽  
Cell Epitope ◽  
Binding Domain ◽  
Epitope Vaccine ◽  
Caveolin 1 ◽  
B Cell Epitope ◽  
Glycoprotein Gp41 ◽  
Hiv 1

scholarly journals Bispecific Engineered Antibody Domains (Nanoantibodies) That Interact Noncompetitively with an HIV-1 Neutralizing Epitope and FcRn

PLoS ONE ◽  
2012 ◽  
Vol 7 (8) ◽  
pp. e42288 ◽  
Author(s):  
Rui Gong ◽  
Yanping Wang ◽  
Tianlei Ying ◽  
Dimiter S. Dimitrov
Keyword(s):  
Neutralizing Epitope ◽  
Hiv 1
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