Subunits of voltage-gated calcium channels in murine spiral ganglion cells

2007 ◽  
Vol 127 (1) ◽  
pp. 8-12 ◽  
Author(s):  
Dinghua Xie ◽  
Peng Hu ◽  
Zi'An Xiao ◽  
Weijing Wu ◽  
Yong Chen ◽  
...  
Keyword(s):  
Calcium Channels ◽  
Ganglion Cells ◽  
Spiral Ganglion ◽  
Voltage Gated ◽  
Voltage Gated Calcium Channels

scholarly journals Voltage-gated calcium channel subunit α2δ-3 shapes light responses of mouse retinal ganglion cells mainly in low and moderate light levels

2020 ◽  
Author(s):  
Hartwig Seitter ◽  
Vithiyanjali Sothilingam ◽  
Boris Benkner ◽  
Marina Garcia Garrido ◽  
Alexandra Kling ◽  
...  
Keyword(s):  
Calcium Channels ◽  
Retinal Ganglion Cells ◽  
Ganglion Cells ◽  
Horizontal Cell ◽  
Gaussian White Noise ◽  
Retinal Ganglion ◽  
Visual Responses ◽  
Electrode Arrays ◽  
Voltage Gated ◽  
Voltage Gated Calcium Channels

AbstractLittle is known about the function of the auxiliary α2δ subunits of voltage-gated calcium channels in the retina. We investigated the role of α2δ-3 (Cacna2d3) using a mouse in which α2δ-3 was knocked out by LacZ insertion. Behavior experiments indicated a normal optokinetic reflex in α2δ-3 knockout animals. Strong expression of α2δ-3 could be localized to horizontal cells using the LacZ-reporter, but horizontal cell mosaic and currents carried by horizontal cell voltage-gated calcium channels were unchanged by the α2δ-3 knockout. In vivo electroretinography revealed unaffected photoreceptor activity and signal transmission to depolarizing bipolar cells. We recorded visual responses of retinal ganglion cells with multi-electrode arrays in scotopic to photopic luminance levels and found subtle changes in α2δ-3 knockout retinas. Spontaneous activity in OFF ganglion cells was elevated in all luminance levels. Differential response strength to high- and low-contrast Gaussian white noise was compressed in ON ganglion cells during mesopic ambient luminance and in OFF ganglion cells during scotopic and mesopic ambient luminances. In a subset of ON ganglion cells, we found a sharp increase in baseline spiking after the presentation of drifting gratings in scotopic luminance. This increase happened after gratings of different spatial properties in knockout compared to wild type retinas. In a subset of ON ganglion cells of the α2δ-3 knockout, we found altered delays in rebound-like spiking to full-field contrast steps in scotopic luminance. In conclusion, α2δ-3 seems to participate in shaping visual responses mostly within brightness regimes when rods or both rods and cones are active.

Zinc (Zn2+) blocks voltage gated calcium channels in cultured rat dorsal root ganglion cells

1992 ◽  
Vol 593 (1) ◽  
pp. 77-81 ◽  
Author(s):  
Dietrich Büsselberg ◽  
Dagmar Michael ◽  
Martyn L. Evans ◽  
David O. Carpenter ◽  
Helmut L. Haas
Keyword(s):  
Dorsal Root Ganglion ◽  
Calcium Channels ◽  
Dorsal Root ◽  
Ganglion Cells ◽  
Voltage Gated ◽  
Voltage Gated Calcium Channels ◽  
Dorsal Root Ganglion Cells

scholarly journals Presynaptic Paraneoplastic Disorders of the Neuromuscular Junction: An Update

2021 ◽  
Vol 11 (8) ◽  
pp. 1035
Author(s):  
Maria Pia Giannoccaro ◽  
Patrizia Avoni ◽  
Rocco Liguori
Keyword(s):  
Potassium Channels ◽  
Neuromuscular Junction ◽  
Calcium Channels ◽  
Myasthenia Gravis ◽  
Neuromuscular Transmission ◽  
Voltage Gated ◽  
Voltage Gated Calcium Channels ◽  
Immune Mediated ◽  
Recent Developments ◽  
Myasthenic Syndrome

The neuromuscular junction (NMJ) is the target of a variety of immune-mediated disorders, usually classified as presynaptic and postsynaptic, according to the site of the antigenic target and consequently of the neuromuscular transmission alteration. Although less common than the classical autoimmune postsynaptic myasthenia gravis, presynaptic disorders are important to recognize due to the frequent association with cancer. Lambert Eaton myasthenic syndrome is due to a presynaptic failure to release acetylcholine, caused by antibodies to the presynaptic voltage-gated calcium channels. Acquired neuromyotonia is a condition characterized by nerve hyperexcitability often due to the presence of antibodies against proteins associated with voltage-gated potassium channels. This review will focus on the recent developments in the autoimmune presynaptic disorders of the NMJ.

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