The Alteration of Penicillin-Binding Proteins (PBPs) in Drug-resistant Streptococcus pneumoniae Isolated from Acute Otitis Media

1999 ◽  
Vol 119 (540) ◽  
pp. 67-71
Author(s):  
Yuichi Tsurusako, Kunihiro Fukushima, Kazu
Keyword(s):  
Streptococcus Pneumoniae ◽  
Otitis Media ◽  
Binding Proteins ◽  
Acute Otitis Media ◽  
Drug Resistant ◽  
Penicillin Binding Proteins

scholarly journals Increasing Ceftriaxone Resistance and Multiple Alterations of Penicillin-Binding Proteins among Penicillin-Resistant Streptococcus pneumoniae Isolates in Taiwan

2007 ◽  
Vol 51 (9) ◽  
pp. 3404-3406 ◽  
Author(s):  
Cheng-Hsun Chiu ◽  
Lin-Hui Su ◽  
Yhu-Chering Huang ◽  
Jui-Chia Lai ◽  
Hsiu-Ling Chen ◽  
...  
Keyword(s):  
Streptococcus Pneumoniae ◽  
Amino Acid ◽  
Binding Proteins ◽  
Binding Protein ◽  
Penicillin Binding Protein ◽  
Penicillin Binding Proteins

ABSTRACT The rate of nonsusceptibility of penicillin-resistant Streptococcus pneumoniae strains to ceftriaxone increased significantly in Taiwan in 2005. Approximately 90% of the ceftriaxone-nonsusceptible isolates were found to be of four major serotypes (serotypes 6B, 14, 19F, and 23F). Seven amino acid alterations in the penicillin-binding protein 2B transpeptidase-encoding region specifically contributed to the resistance.

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