scholarly journals Serum Antibody Response to Five Streptococcus pneumoniae Proteins During Acute Otitis Media in Otitis-prone and Non–otitis-prone Children

2011 ◽  
Vol 30 (8) ◽  
pp. 645-650 ◽  
Author(s):  
Ravinder Kaur ◽  
Janet R. Casey ◽  
Michael E. Pichichero
Keyword(s):  
Streptococcus Pneumoniae ◽  
Antibody Response ◽  
Otitis Media ◽  
Serum Antibody ◽  
Acute Otitis Media ◽  
Serum Antibody Response

scholarly journals Serum antibody response to Moraxella catarrhalis proteins OMP CD, OppA, Msp22, Hag, and PilA2 after nasopharyngeal colonization and acute otitis media in children

Vaccine ◽  
2015 ◽  
Vol 33 (43) ◽  
pp. 5809-5814 ◽  
Author(s):  
Dabin Ren ◽  
Anthony L. Almudevar ◽  
Timothy F. Murphy ◽  
Eric R. Lafontaine ◽  
Anthony A. Campagnari ◽  
...  
Keyword(s):  
Antibody Response ◽  
Otitis Media ◽  
Moraxella Catarrhalis ◽  
Serum Antibody ◽  
Acute Otitis Media ◽  
Nasopharyngeal Colonization ◽  
Serum Antibody Response

scholarly journals Serum antibody response in adult volunteers elicited by injection of Streptococcus pneumoniae type 12F polysaccharide alone or conjugated to diphtheria toxoid.

1990 ◽  
Vol 58 (7) ◽  
pp. 2309-2312 ◽  
Author(s):  
A Fattom ◽  
C Lue ◽  
S C Szu ◽  
J Mestecky ◽  
G Schiffman ◽  
...  
Keyword(s):  
Streptococcus Pneumoniae ◽  
Antibody Response ◽  
Serum Antibody ◽  
Diphtheria Toxoid ◽  
Serum Antibody Response ◽  
Adult Volunteers

Serum antibody response to pneumococcal otitis media

1982 ◽  
Vol 1 (4) ◽  
pp. 245-252 ◽  
Author(s):  
MARKKU KOSKELA ◽  
MAIJA LEINONEN ◽  
JUKKA LUOTONEN
Keyword(s):  
Antibody Response ◽  
Otitis Media ◽  
Serum Antibody ◽  
Serum Antibody Response

Serum antibody response to Opisthorchis viverrini antigen as a marker for opisthorchiasis-associated cholangiocarcinoma

1994 ◽  
Vol 88 (4) ◽  
pp. 471-474 ◽  
Author(s):  
P.S. Akai ◽  
S. Pungpak ◽  
W. Chaicumpa ◽  
K. Viroj ◽  
D. Bunnag ◽  
...  
Keyword(s):  
Antibody Response ◽  
Serum Antibody ◽  
Opisthorchis Viverrini ◽  
Serum Antibody Response

scholarly journals Comparison of Newcastle disease vaccine administered as powder or liquid in relation to the serum antibody response and adverse vaccinal reactions in broilers

2015 ◽  
Vol 44 (2) ◽  
pp. 114-123 ◽  
Author(s):  
W. J. M. Landman ◽  
K. Huyge ◽  
J. P. Remon ◽  
C. Vervaet ◽  
J. H. H. van Eck
Keyword(s):  
Antibody Response ◽  
Newcastle Disease ◽  
Serum Antibody ◽  
Serum Antibody Response ◽  
Newcastle Disease Vaccine

Study of Antibody Levels in Children with Purulent Otitis Media

1980 ◽  
Vol 89 (3_suppl) ◽  
pp. 117-120 ◽  
Author(s):  
P. Branefors ◽  
T. Dahlberg ◽  
O. Nylén
Keyword(s):  
Otitis Media ◽  
Serum Antibody ◽  
Acute Otitis Media ◽  
High Serum ◽  
Haemophilus Influenzae Type ◽  
Enzyme Linked Immunosorbent Assay ◽  
Polysaccharide Antigens ◽  
Antibody Titers ◽  
Iga Antibody ◽  
Antibody Levels

A series of episodes of acute otitis media were studied with reference to the bacterial findings in the nasopharynx and the specific antibody response in a group of children nine months to ten years of age, with previous frequent episodes of acute otitis media, Serum IgG, IgM and IgA antibody levels against five polysaccharide antigens, namely Haemophilus influenzae type b and Streptococcus pneumoniae types 3, 6, 19 and 23, were studied by means of an enzyme-linked immunosorbent assay. The selection of polysaccharide antigens was based on isolation frequency. The sera to be tested were tenfold serially diluted. An extinction of 0.2 over the base was taken as the end-point titer and expressed as in-log10. The results showed that most children including those under three years of age showed increasing homologous antibody titers at an infection, or had already initially very high antibody titers, especially of the IgG class. The titers reached levels of 104 to 105. In some cases, however, it could be shown that high serum antibody titers did not give protection against a new infection with the same serological type of bacteria. It was also demonstrated that most children, regardless of age, had IgG and IgM titers against the heterologous antigens. In some cases the levels were quite high (103 to 104). However, the IgA antibody levels were lower and in a considerable number of samples antibodies were not even detectable.

scholarly journals Systemic Inflammatory Responses in Children with Acute Otitis Media Due to Streptococcus pneumoniae and the Impact of Treatment with Clarithromycin

2003 ◽  
Vol 10 (4) ◽  
pp. 721-724 ◽  
Author(s):  
Gunter Scharer ◽  
Frank Zaldivar ◽  
Guillermo Gonzalez ◽  
Ofelia Vargas-Shiraishi ◽  
Jasjit Singh ◽  
...  
Keyword(s):  
Streptococcus Pneumoniae ◽  
Otitis Media ◽  
Antibiotic Treatment ◽  
Statistical Significance ◽  
Objective Assessment ◽  
Acute Otitis Media ◽  
Serum Levels ◽  
Asymptomatic Children ◽  
Tnf Α ◽  
The Impact

ABSTRACT This pilot study was designed to determine the serum cytokine profile of acute otitis media (AOM) due to Streptococcus pneumoniae and the impact of clarithromycin (Abbott Laboratories, Inc). Serum levels of interleukin-1β (IL-1β), tumor necrosis factor alpha (TNF-α), IL-6, and IL-8 were measured at diagnosis and 3 to 5 days after start of antibiotic treatment in 10 patients (mean age, 18.3 ± 13.9 months) who had middle ear fluid culture positive for S. pneumoniae. The mean concentrations of all cytokines were elevated at diagnosis of AOM compared to levels in healthy controls, yet only IL-6 reached statistical significance (P = 0.05). IL-6 showed a statistically significant decrease in mean serum concentration at visit 2 (P = 0.03). IL-8 displayed a similar pattern to IL-6, but the difference between samples from day 1 and day 2 did not reach statistical significance. The cytokines IL-1β and TNF-α appear to be elevated in the serum of patients with S. pneumoniae AOM, but there was no significant change between mean serum levels obtained pre- and postinitiation of antibiotic treatment in the time frame studied. The results suggest a systemic inflammatory response as evidenced by increased IL-6. A significant decrease of IL-6 and improvement of clinical symptoms were observed. Determining cytokine levels, especially IL-6, in AOM could offer a powerful tool for objective assessment of response to treatment, minimizing unnecessary treatment of asymptomatic children who may still have some otoscopic findings suggestive of AOM at follow-up visits.

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