Flow‐Injection Spectrophotometric Determination of N‐acetylcysteine in Pharmaceutical Formulations with On‐Line Solid‐Phase Reactor Containing Zn(II) Phosphate Immobilized in a Polyester Resin

2007 ◽  
Vol 40 (18) ◽  
pp. 3417-3429 ◽  
Author(s):  
Willian Toito Suarez ◽  
Alexandro Alves Madi ◽  
Fernando Campanhã Vicentini ◽  
Orlando Fatibello‐Filho
Keyword(s):  
Spectrophotometric Determination ◽  
Flow Injection ◽  
Polyester Resin ◽  
Solid Phase ◽  
Pharmaceutical Formulations ◽  
Solid Phase Reactor ◽  
On Line

scholarly journals Flow-injection spectrophotometric determination of captopril in pharmaceutical formulations using a new solid-phase reactor containing AgSCN immobilized in a polyurethane resin

2012 ◽  
Vol 48 (2) ◽  
pp. 325-333 ◽  
Author(s):  
Fernando Campanhã Vicentini ◽  
Willian Toito Suarez ◽  
Éder Tadeu Gomes Cavalheiro ◽  
Orlando Fatibello-Filho
Keyword(s):  
Flow Injection ◽  
Solid Phase ◽  
Pharmaceutical Formulations ◽  
Analysis Procedure ◽  
Polyurethane Resin ◽  
Analytical Curve ◽  
Relative Standard ◽  
Solid Phase Reactor ◽  
Simple Flow

A simple flow-injection analysis procedure was developed for determining captopril in pharmaceutical formulations employing a novel solid-phase reactor containing silver thiocyanate immobilized in a castor oil derivative polyurethane resin. The method was based on silver mercaptide formation between the captopril and Ag(I) in the solid-phase reactor. During such a reaction, the SCN- anion was released and reacted with Fe3+, which generated the FeSCN2+ complex that was continuously monitored at 480 nm. The analytical curve was linear in the captopril concentration range from 3.0 × 10-4 mol L-1 to 1.1 × 10-3 mol L-1 with a detection limit of 8.0 × 10-5 mol L-1. Recoveries between 97.5% and 103% and a relative standard deviation of 2% for a solution containing 6.0 × 10-4 mol L-1 captopril (n = 12) were obtained. The sample throughput was 40 h-1 and the results obtained for captopril in pharmaceutical formulations using this procedure and those obtained using a pharmacopoeia procedure were in agreement at a 95% confidence level.

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