Complementary Acupuncture Treatment Increases Cerebral Metabolism in Patients with Parkinson's Disease

2009 ◽  
Vol 119 (8) ◽  
pp. 1190-1197 ◽  
Author(s):  
Yong Huang ◽  
Xuemei Jiang ◽  
Ying Zhuo ◽  
Anwu Tang ◽  
Gustav Wik
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Acupuncture Treatment ◽  
Cerebral Metabolism

scholarly journals The development of visual neuroimaging research of acupuncture in the treatment of Parkinson’s disease

2019 ◽  
Vol 5 (3) ◽  
pp. 161-168 ◽  
Author(s):  
Yuan Yang ◽  
Suhua Miao ◽  
Rongsong Zhou ◽  
Yu Ma ◽  
Yuqi Zhang
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Neuronal Activity ◽  
Structural Changes ◽  
Neurodegenerative Disorder ◽  
Cerebral Metabolism ◽  
Experimental Studies ◽  
Brain Regions ◽  
Imaging Studies ◽  
Surgical Treatments

Parkinson’s disease (PD) is a progressive neurodegenerative disorder commonly observed in middle-aged and elderly. Currently, its etiology and pathogenesis are still not completely understood. It is associated with many symptoms that severely affect patients’ health and quality of life. At present, the PD clinical treatment mainly aimed to alleviate symptoms, and both medicinal and surgical treatments have side effects and treatment blind spots. The use of acupuncture for the treatment of PD is relatively widespread, and its safety and efficacy have been gradually accepted by the public and medical professions. However, the efficacy of acupuncture in experimental studies remains controversial. Therefore, this paper reviews imaging studies on the use of acupuncture for the treatment of PD. From the study, it shows that acupuncture can improve the neuronal activity, activate the neuronal activity in damaged brain regions, affect relevant neural networks and brain circulation, improve cerebral metabolism, and cause structural changes in related brain regions. Intuitive and visible imaging studies provide objective bases on the use of acupuncture for the treatment of PD.

Effect of Pallidotomy on Cerebral Metabolism in Parkinson's Disease

NeuroImage ◽  
1998 ◽  
Vol 7 (4) ◽  
pp. S999
Author(s):  
M.L. Giroux ◽  
S.T. Grafton ◽  
J.L. Vitek ◽  
J.R. Votaw ◽  
M.L. DeLong ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cerebral Metabolism

scholarly journals Investigation of Therapeutic Response Markers for Acupuncture in Parkinson’s Disease: An Exploratory Pilot Study

Diagnostics ◽  
2021 ◽  
Vol 11 (9) ◽  
pp. 1697
Author(s):  
Sangmin Park ◽  
Aeyung Kim ◽  
Gunhyuk Park ◽  
Ojin Kwon ◽  
Sangsoo Park ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Pilot Study ◽  
Therapeutic Response ◽  
Acupuncture Treatment ◽  
Gene Marker ◽  
Dopaminergic Therapy ◽  
Gait Parameters ◽  
Repeat Domain ◽  
Previous Clinical Trial

In this preliminary pilot study, we investigated the specific genes implicated in the therapeutic response to acupuncture in patients with Parkinson’s disease (PD). Transcriptome alterations following acupuncture in blood samples collected during our previous clinical trial were analyzed along with the clinical data of six patients with PD, of which a representative patient was selected for transcriptomic analysis following acupuncture. We also examined the changes in the expression of PD biomarker genes known to be dysregulated in both the brain and blood of patients with PD. We validated these gene expression changes using quantitative real-time polymerase chain reaction (qPCR) in the blood of the remaining five patients with PD who received acupuncture treatment. Following acupuncture treatment, the transcriptomic alterations in the representative patient were similar to those induced by dopaminergic therapy. Among the PD biomarkers, ankyrin repeat domain 22 (ANKRD22), upregulated following dopaminergic therapy, and synapsin 1 (SYN1), a common gene marker for synaptic dysfunction in PD, were upregulated following acupuncture. These alterations correlated with changes in gait parameters in patients with PD. Our data suggest ANKRD22 and SYN1 as potential biomarkers to predict/monitor therapeutic responses to acupuncture in patients with PD, especially in those with gait disturbance. Further research is needed to confirm these findings in a large sample of patients with PD.

Direct comparison between regional cerebral metabolism in progressive supranuclear palsy and Parkinson's disease

2005 ◽  
Vol 20 (8) ◽  
pp. 1021-1030 ◽  
Author(s):  
Reinoud C. Klein ◽  
Bauke M. de Jong ◽  
Joeke J. de Vries ◽  
Klaus L. Leenders
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Progressive Supranuclear Palsy ◽  
Cerebral Metabolism

scholarly journals Effects of Acupuncture Treatment on Functional Brain Networks of Parkinson’s Disease Patients during Treadmill Walking: An fNIRS Study

2020 ◽  
Vol 10 (24) ◽  
pp. 8954
Author(s):  
Seung Hyun Lee ◽  
Sang-Soo Park ◽  
Jung-hee Jang ◽  
Sang Hyeon Jin ◽  
Young-Soo Baik ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Neural Plasticity ◽  
Primary Motor Cortex ◽  
Evaluation Method ◽  
Acupuncture Treatment ◽  
Block Design ◽  
Intervention Group ◽  
Cortical Activation ◽  
Functional Near Infrared Spectroscopy

Acupuncture is increasingly being used as an alternative treatment for patients with Parkinson’s disease (PD). We aimed to evaluate the effects of acupuncture on gait-related brain function in patients with PD using functional near-infrared spectroscopy (fNIRS). Twenty-four patients with PD were randomly assigned to intervention (acupuncture twice a week for 4 weeks) or control (non-treatment) groups. fNIRS experiments applying a block design were performed at baseline (0 weeks) and 4- and 8-week follow-up and cortical activation and connectivity were evaluated. After acupuncture treatment, oxy-hemoglobin (HbO) levels in the intervention group were significantly increased in the primary motor cortex (M1), supplementary motor area (SMA), and prefrontal cortex (PFC). Furthermore, following acupuncture treatment in the intervention group, the connectivities in the M1 and PFC regions increased. The results show that acupuncture may be a useful complementary treatment for gait disturbances in patients with PD, and fNIRS can be applicable to evaluate neural plasticity directly. The evaluation method in this paper can be used to assess the neural plasticity related to various rehabilitation techniques.

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