Lysergic Acid Diethylamide (LSD-25): XXIX. The Response Index as a Measure of Threshold Activity of Psychotropic Drugs in Man

1959 ◽  
Vol 48 (1) ◽  
pp. 65-78 ◽  
Author(s):  
H. A. Abramson
Keyword(s):  
Psychotropic Drugs ◽  
Lysergic Acid ◽  
Lysergic Acid Diethylamide ◽  
Response Index

scholarly journals The role of serendipity in drug discovery

2006 ◽  
Vol 8 (3) ◽  
pp. 335-344 ◽  
Keyword(s):  
Drug Discovery ◽  
Psychotropic Drugs ◽  
Pharmacological Treatment ◽  
Chloral Hydrate ◽  
Potassium Bromide ◽  
Lysergic Acid ◽  
Lysergic Acid Diethylamide ◽  
Empirical Results ◽  
The Many

Serendipity is one of the many factors that may contribute to drug discovery. It has played a role in the discovery of prototype psychotropic drugs that led to modern pharmacological treatment in psychiatry. It has also played a role in the discovery of several drugs that have had an impact on the development of psychiatry. "Serendipity" in drug discovery implies the finding of one thing while looking for something else. This was the case in six of the twelve serendipitous discoveries reviewed in this paper, i.e., aniline purple, penicillin, lysergic acid diethylamide, meprobamate, chlorpromazine, and imipramine. In the case of three drugs, i.e., potassium bromide, chloral hydrate, and lithium, the discovery was serendipitous because an utterly false rationale led to correct empirical results; and in case of two others, i.e., iproniazid and sildenafil, because valuable indications were found for these drugs which were not initially those sought The discovery of one of the twelve drugs, chlordiazepoxide, was sheer luck.

scholarly journals Changes in Online Psychoactive Substance Trade via Telegram during the COVID-19 Pandemic

2021 ◽  
pp. 1-6
Author(s):  
Matthijs Blankers ◽  
Daan van der Gouwe ◽  
Lavinia Stegemann ◽  
Laura Smit-Rigter
Keyword(s):  
Social Media ◽  
The Netherlands ◽  
Relative Increase ◽  
Lysergic Acid ◽  
Lysergic Acid Diethylamide ◽  
Psychoactive Substance ◽  
Before And After ◽  
Other Substances

<b><i>Background:</i></b> In this article, we present an evaluation of online psychoactive substance trade via Telegram, a free encrypted social media messenger service. The evaluation took place during the COVID-19 pandemic, which allowed us to monitor the effects of the spring 2020 lockdown in the Netherlands on substance trade via Telegram. <b><i>Objective:</i></b> The objective of this study was to evaluate whether changes in psychoactive substance trade on Telegram markets in the Netherlands can be observed during the COVID-19 pandemic. <b><i>Results:</i></b> Between December 2, 2019, and June 29, 2020, a total of 70,226 posts appeared in two analyzed Telegram groups. A total of 5,643 posts were psychoactive substance related. Based on the analyzed posts, Telegram is mostly a ‘“sellers” market as only a minority of the posts (6.3%) could be identified as a request for a substance. The proportion of posts related to specific substances varied between the periods before, during, and after the lockdown. The proportion of posts on the stimulants ecstasy, cocaine, and amphetamine was lower during the lockdown than before and after. For psychedelics – ketamine, lysergic acid diethylamide (LSD), and 2,5-dimethoxy-4-bromophenethylamine (2C-B) – and other substances, there was a relative increase in the number of posts during the lockdown, which was maintained after the lockdown. <b><i>Conclusions:</i></b> Telegram analysis shows that in the Netherlands, online psychoactive substance trade may have been affected during the COVID-19 pandemic. The direction of this effect was different for different classes of substances.

Production of Tolerance to Psychosis-Producing Doses of Lysergic Acid Diethylamide

Science ◽  
1957 ◽  
Vol 126 (3281) ◽  
pp. 1020-1020 ◽  
Author(s):  
H. A. ABRAMSON ◽  
B. SKLAROFSKY ◽  
M. O. BARON ◽  
N. FREMONT-SMITH
Keyword(s):  
Lysergic Acid ◽  
Lysergic Acid Diethylamide

CLINICAL PHARMACOLOGY OF LYSERGIC ACID DIETHYLAMIDE

1997 ◽  
Vol 4 (5) ◽  
pp. 211 ◽  
Author(s):  
Kari Blaho ◽  
Kevin Merigian ◽  
Stephen Winbery ◽  
Stephen A. Geraci ◽  
Chantay Smartt
Keyword(s):  
Clinical Pharmacology ◽  
Lysergic Acid ◽  
Lysergic Acid Diethylamide

Oral Sernyl in Obsessive States

1961 ◽  
Vol 107 (446) ◽  
pp. 109-114 ◽  
Author(s):  
Brian M. Davies
Keyword(s):  
Preliminary Report ◽  
Therapeutic Agent ◽  
Lysergic Acid ◽  
Lysergic Acid Diethylamide ◽  
Psychological Disturbances ◽  
Synthetic Drug ◽  
Severe Disturbance

Sernyl, 1 aryl-cyclo-hexylamine, is a synthetic drug first used by the anaesthetists because, when given intravenously, it produces analgesia. However, the occurrence of psychological disturbances post-operatively led to the investigation of this drug by psychiatrists. It was found that Sernyl produces many interesting psychological disturbances, some of which resemble the primary symptoms of schizophrenia (Davies and Beech, 1960). In a previous paper (Davies, 1960) Sernyl was given intravenously to five patients with long-standing psychoneurotic illnesses. It proved to be an effective abreactive agent and produced some interesting results in three of the patients who had obsessional symptoms. Sernyl, in the doses used, is not an hallucinogen, though it produces other effects similar to lysergic acid diethylamide, which has been used extensively as a therapeutic agent, particularly in obsessional states (Sandison et al., 1954). The preliminary report suggested that Sernyl might have some practical advantages over LSD—in particular, it produced a less severe disturbance and its effects were over more quickly. Further investigations were clearly indicated and this present paper reports on the use of oral Sernyl in five patients with obsessional illnesses.

Characterisation of [3H]lysergic acid diethylamide binding to a 5-hydroxytryptamine receptor on human platelet membranes

1984 ◽  
Vol 97 (1-2) ◽  
pp. 87-93 ◽  
Author(s):  
David P. Geaney ◽  
Michael Schächter ◽  
J.Martin Elliot ◽  
David G. Grahame-Smith
Keyword(s):  
Human Platelet ◽  
Lysergic Acid ◽  
Lysergic Acid Diethylamide ◽  
Platelet Membranes
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