scholarly journals The role of serendipity in drug discovery

2006 ◽  
Vol 8 (3) ◽  
pp. 335-344 ◽  
Keyword(s):  
Drug Discovery ◽  
Psychotropic Drugs ◽  
Pharmacological Treatment ◽  
Chloral Hydrate ◽  
Potassium Bromide ◽  
Lysergic Acid ◽  
Lysergic Acid Diethylamide ◽  
Empirical Results ◽  
The Many

Serendipity is one of the many factors that may contribute to drug discovery. It has played a role in the discovery of prototype psychotropic drugs that led to modern pharmacological treatment in psychiatry. It has also played a role in the discovery of several drugs that have had an impact on the development of psychiatry. "Serendipity" in drug discovery implies the finding of one thing while looking for something else. This was the case in six of the twelve serendipitous discoveries reviewed in this paper, i.e., aniline purple, penicillin, lysergic acid diethylamide, meprobamate, chlorpromazine, and imipramine. In the case of three drugs, i.e., potassium bromide, chloral hydrate, and lithium, the discovery was serendipitous because an utterly false rationale led to correct empirical results; and in case of two others, i.e., iproniazid and sildenafil, because valuable indications were found for these drugs which were not initially those sought The discovery of one of the twelve drugs, chlordiazepoxide, was sheer luck.

scholarly journals Possible role of biochemiluminescent photons for lysergic acid diethylamide (LSD)-induced phosphenes and visual hallucinations

2017 ◽  
Vol 28 (1) ◽  
pp. 77-86 ◽  
Author(s):  
Gábor Kapócs ◽  
Felix Scholkmann ◽  
Vahid Salari ◽  
Noémi Császár ◽  
Henrik Szőke ◽  
...  
Keyword(s):  
Visual System ◽  
Lysergic Acid ◽  
Healthy People ◽  
Lysergic Acid Diethylamide ◽  
Visual Hallucinations ◽  
Interest In Research ◽  
The Brain

AbstractToday, there is an increased interest in research on lysergic acid diethylamide (LSD) because it may offer new opportunities in psychotherapy under controlled settings. The more we know about how a drug works in the brain, the more opportunities there will be to exploit it in medicine. Here, based on our previously published papers and investigations, we suggest that LSD-induced visual hallucinations/phosphenes may be due to the transient enhancement of bioluminescent photons in the early retinotopic visual system in blind as well as healthy people.

Psychedelic use and intimate partner violence: The role of emotion regulation

2018 ◽  
Vol 32 (7) ◽  
pp. 749-755 ◽  
Author(s):  
Michelle S Thiessen ◽  
Zach Walsh ◽  
Brian M Bird ◽  
Adele Lafrance
Keyword(s):  
Intimate Partner Violence ◽  
Emotion Regulation ◽  
Partner Violence ◽  
Physical Violence ◽  
Community Sample ◽  
Negative Relationship ◽  
Intimate Partner ◽  
Lysergic Acid ◽  
Lysergic Acid Diethylamide

Background: Recent evidence suggests that psychedelic use predicts reduced perpetration of intimate partner violence among men involved in the criminal justice system. However, the extent to which this association generalizes to community samples has not been examined, and potential mechanisms underlying this association have not been directly explored. Aims: The present study examined the association between lifetime psychedelic use and intimate partner violence among a community sample of men and women. The study also tested the extent to which the associations were mediated by improved emotion regulation. Methods: We surveyed 1266 community members aged 16–70 (mean age=22.78, standard deviation =7.71) using an online questionnaire that queried substance use, emotional regulation, and intimate partner violence. Respondents were coded as psychedelic users if they reported one or more instance of using lysergic acid diethylamide and/or psilocybin mushrooms in their lifetime. Results/outcomes: Males reporting any experience using lysergic acid diethylamide and/or psilocybin mushrooms had decreased odds of perpetrating physical violence against their current partner (odds ratio=0.42, p<0.05). Furthermore, our analyses revealed that male psychedelic users reported better emotion regulation when compared to males with no history of psychedelic use. Better emotion regulation mediated the relationship between psychedelic use and lower perpetration of intimate partner violence. This relationship did not extend to females within our sample. Conclusions/interpretation: These findings extend prior research showing a negative relationship between psychedelic use and intimate partner violence, and highlight the potential role of emotion regulation in this association.

scholarly journals Role of the 5-HT2A Receptor in Self- and Other-Initiated Social Interaction in Lysergic Acid Diethylamide-Induced States: A Pharmacological fMRI Study

2018 ◽  
Vol 38 (14) ◽  
pp. 3603-3611 ◽  
Author(s):  
Katrin H. Preller ◽  
Leonhard Schilbach ◽  
Thomas Pokorny ◽  
Jan Flemming ◽  
Erich Seifritz ◽  
...  
Keyword(s):  
Social Interaction ◽  
Lysergic Acid ◽  
Lysergic Acid Diethylamide ◽  
Self And Other ◽  
Fmri Study

Lysergic acid diethylamide-induced Fos expression in rat brain: role of serotonin-2A receptors

Neuroscience ◽  
2002 ◽  
Vol 114 (3) ◽  
pp. 707-713 ◽  
Author(s):  
P.J Gresch ◽  
L.V Strickland ◽  
E Sanders-Bush
Keyword(s):  
Rat Brain ◽  
Lysergic Acid ◽  
Lysergic Acid Diethylamide ◽  
Fos Expression ◽  
Serotonin 2A

Neuropsychopharmacology: Changing the Face of Psychotropic Drug Discovery

CNS Spectrums ◽  
1997 ◽  
Vol 2 (9) ◽  
pp. 26-34
Author(s):  
B. E. Leonard
Keyword(s):  
Drug Discovery ◽  
Psychotropic Drug ◽  
Psychotropic Drugs ◽  
First Century ◽  
Central Nervous System Diseases ◽  
Trace Amine ◽  
Causative Agents ◽  
The Face ◽  
The Impact

AbstractThis review speculates on the changes currently taking place in psychopharmacology that will alter the course of psychotropic drug discovery and application in the coming millennium. The importance of endocoids as causative agents in central nervous system diseases; the role of neuropeptides and “trace” amine transmitters; the impact of imaging methods in elucidating the mechanism of action of psychotropic drugs; gene therapy; and the new role of psychoneuroimmunology in drug discovery are predicted to have a major impact in both the research and development of new psychotropic drugs in the twenty-first century.

On Future Directions in Pathology

1982 ◽  
Vol 40 ◽  
pp. 274-277
Author(s):  
Benjamin F. Trump ◽  
Irene K. Berezesky ◽  
Raymond T. Jones
Keyword(s):  
Electron Microscopy ◽  
Transmission Electron Microscopy ◽  
Clinical Pathology ◽  
Future Directions ◽  
Diagnostic Pathology ◽  
The Past ◽  
Transmission Electron ◽  
Organ Systems ◽  
The Many

The role of electron microscopy and associated techniques is assured in diagnostic pathology. At the present time, most of the progress has been made on tissues examined by transmission electron microscopy (TEM) and correlated with light microscopy (LM) and by cytochemistry using both plastic and paraffin-embedded materials. As mentioned elsewhere in this symposium, this has revolutionized many fields of pathology including diagnostic, anatomic and clinical pathology. It began with the kidney; however, it has now been extended to most other organ systems and to tumor diagnosis in general. The results of the past few years tend to indicate the future directions and needs of this expanding field. Now, in addition to routine EM, pathologists have access to the many newly developed methods and instruments mentioned below which should aid considerably not only in diagnostic pathology but in investigative pathology as well.

Sign in / Sign up

Export Citation Format

Share Document