​Allelopathic Chemical Screening of Aqueous Extracts of Coir Pith on Seedling Growth of Black Gram (Vigna mungo L.) and Green Gram (Vigna radiata L.)

Background: Black gram (Vigna mungo L.) and Green gram (Vigna radiata L.) were mostly used as chemical residue indicators for testing the persistence of pesticides, fungicides and herbicides, etc. in the soil. Presently, the coir pith was used as a medium of nursery for many seeds and seedling production. This study evaluated the inhibition effects and screening of allelopathic chemicals from aqueous extracts of coir pith and composting coir pith on the back gram and green gram by response index method and GCMS/MS analysis. Methods: The coir pith and composted coir pith soaked the ratio of 1:10 for 24 hrs, filtered through Whatman No.1 filter paper. The inhibition effect tested for germination and seedling growth of black gram and green gram was sown in poly pots. The carbon: nitrogen ratio and the total organic carbon were analyzed by dry combustion method, Kjeldahl method and GCMS/MS analysis. Result: The phytotoxic substances are present in coir pith, which can be exterminated by composting the coir pith for better growth and development of seedlings. The negative response index (RI), high C: N ratio and chemical compounds like tocopherol, fucoxanthin, tetramethyl heptadeca, dichloroacetamide, tetrazole, hydroxyethyl palmitate, neocurdione and uridine derivations present in raw coir may have the phytotoxic effect and produced yellowing symptoms in young plants compared to composted coir pith. This is exterminated by composting the coir pith for better growth and development of seedlings as well as used for various agricultural and horticultural nurseries.

Identification of Misconceptions in Science Learning During the Covid-19 Pandemic Using the CRI (Certainty of Response Index) Method for Primary school Students

This research aims to identify the science misconceptions of elementary school students using CRI (Certainty of Response Index), as well as to describe the factors of students' misconceptions at Primary school Muhammadiyah 8 Tulangan. This research uses the descriptive qualitative method. The subjects used in this study were class V, totaling 26 students. Data collection techniques using the test, interviews, and documentation. Based on the results obtained from the research as a whole, the highest misconception is about the concept of the effect of temperature on changes in the shape of objects by 44.70%, the concept of temperature and heat by 39.42%, and the lowest misconception is about the concept of object properties by 32.04%. From the results of research using the CRI (Certainty of Response Index) method, several factors cause misconceptions, namely from the students themselves who come from the initial concept and students wrong intuition, then misconceptions from the teacher, as well as incomplete book explanations. So it can be concluded that science learning during the covid-19 pandemic caused misconceptions for students of Primary school Muhammadiyah 8 Tulangan

The Importance of Systemic Inflammatory Response Index, Systemic Immune-Inflammation Index, and Hemoglobin-Albumin-Lymphocytes-Platelets (HALP) Score in Children With Cancer

Background: Biological inflammatory status in cancer patients is evaluated with various parameters. Limited studies have been conducted on this issue in children. Objectives: This study was done to evaluate the importance of the biological inflammatory status, including systemic inflammatory response index (SIRI), systemic immune-inflammation (SII) index, and hemoglobin-albumin-lymphocytes-platelets (HALP) score in children with cancer. Methods: Demographic characteristics, complete blood count, and biochemical analysis of the patients on admission were recorded retrospectively. Since not meeting the necessary assumptions, the Mann-Whitney U test was used for the comparison of the two groups, and the Kruskal-Wallis test was used for the comparison of more than two groups Results: The SIRI of the patients was statistically higher than the control group (P < 0.0001). Considering lymphoma, central nervous system tumors, and solid tumors, there was a statistical difference between the groups in SII index and SIRI (P values: .0245, and .0060, respectively). Regarding inflammatory biomarkers, according to the extent of cancer (localized or advanced disease), it was found that SIRI was higher in patients with advanced disease (P = 0.0175). The patients who died had a statistically higher HALP score (P = 0.0472). Conclusions: The inflammatory biomarkers can be used in childhood cancers to determine the extent of the disease and predict outcomes. However, in larger patient series, ideal values should be achieved by analyzing the receiver operating characteristic curves and the area under the curve.

Efektivitas Komunikasi Pemasaran Melalui Media Sosial untuk Menumbuhkan Kesadaran Merek Ladang Lima

PT ABA adalah produsen makanan sehat yang menggunakan singkong sebagai bahan baku utamanya. Masalah yang dihadapi perusahaan di bidang pemasaran adalah menumbuhkan kesadaran merek di benak konsumen. Penelitian ini bertujuan untuk menganalisis efektivitas komunikasi pemasaran yang telah dilakukan oleh PT ABA melalui media sosial untuk menumbuhkan kesadaran merek Ladang Lima. Metode yang digunakan adalah deskriptif kuantitatif dengan Customer Response Index (CRI). Hasil dari penelitian ini adalah komunikasi pemasaran yang dilakukan perusahaan melalui media sosial Instagram telah efektif untuk menumbuhkan kesadaran merek, dengan nilai CRI sebesar 43,25%, hal ini juga didukung melalui analisis kesadaran merek pada tingkat top of mind, makanan sehat yang pertama kali disebut oleh responden dengan jawaban terbanyak adalah merek Ladang Lima. Kata Kunci: Efektivitas, Komunikasi Pemasaran, Kesadaran Merek.

Systemic Inflammation Response Index (SIRI) Predicts Clinical Outcome and Improves NCCN-IPI Scoring in Primary Gastrointestinal Diffuse Large B-Cell Lymphoma

Background: Systemic inflammation response index (SIRI) is a novel inflammatory hallmark that is proposed as an adverse prognosticator in a variety of malignancies. Nevertheless, the correlation between SIRI and primary gastrointestinal diffuse large B cell lymphoma (PGI-DLBCL) remains unknown. Our study aimed to evaluate the prognostic value of SIRI in PGI-DLBCL patients treated with CHOP-based therapies and establishing a highly discriminating risk prediction model compared with the National Comprehensive Cancer Network-International Prognostic Index (NCCN-IPI) score. Methods: This retrospective analysis incorporated 102 PGI-DCBCL patients (57 patients with gastric DLBCL and 45 patients with intestinal DLBCL) newly diagnosed between January 2011 and June 2020. The SIRI was calculated by utilizing the peripheral blood neutrophil (N), monocyte (M), and lymphocyte (L) counts collected in the last ≤3 days before the initiation of the immunochemotherapy: SIRI= N × M/L. Pretreatment SIRI cutoff that may distinguish the study population into two gatherings with distinctive overall survival (OS) results which was calculated by the receiver operating characteristic (ROC) curve analysis. The prognostic factors associated with OS, the primary endpoint, were screened by multivariate Cox regression analyses and log-rank test as well as progression-free survival (PFS), the secondary endpoint. Performances of the novel model were compared using the area under the curve (AUC) and C-index in the cohort. Results: Among the 102 patients analyzed, there were 64 (62.7%) males and 38 (37.3%) females. The median follow-up time was 39.5 months (95% CI: 30.7-48.2), ranging from 2 to 102 months. A total of 33 patients (32.4%) presented B symptoms at the initial assessment, 74 (72.5%) of patients revealed stage III or IV disease, and 24 (23.5%) of patients had more than one extranodal involvement. Twenty-seven patients (26.5%) showed ECOG PS&gt;2. The optimal SIRI cutoff was identified as 1.34 value by OS outcome, which divided patients into two groups. There were not significant differences in clinical characteristics between two groups (Table 1). Based on the cut-off value of SIRI, the outcomes of patients were distinct within two groups, which was shown in Figure 1. At a median follow-up of 39.5 (95% CI: 30.7-48.2) months, 86 (84.3%) patients were still alive (98.4% for SIRI &lt;1.34 vs 62.5% for SIRI ≥1.34; p &lt; 0.001). Cox regression analysis found three negative prognostic factors on OS: SIRI≥ 1.34 (P=0.001), B symptom (P=0.001), LDH&gt;ULN (P=0.005). Accordingly, SIRI≥ 1.34 (P=0.002), age&gt;60 (P=0.011) and LDH&gt;ULN (P=0.002) emerged to be the indicators in relation to considerably inferior PFS times. Consequences of the multivariate analyses revealed that the prognostic significance of the SIRI on OS and PFS outcomes was independent of other confounders. SIRI could be used to combine with NCCN-IPI and develop a risk score to improve the NCCN-IPI score and identify PGI-DLBCL patients with poor prognosis. Patients with SIRI≥1.34 were allocated 2 points as a risk factor which was calculated in terms of the β coefficients compared with the effect of LDH level (&gt;ULN) in the multivariate analysis of OS. This established an integrated scoring model with a maximum of 10 points when we combined NCCN-IPI with SIRI. Patients were divided into four risk groups and identified as low-risk group (0−3 points), low-intermediate-risk group (4−5 points), high-intermediate-risk group (6−7 points), and high-risk group (≥8 points). As a result, the prognostic and discriminatory capability of the NCCN-IPI plus SIRI was superior to NCCN-IPI alone (AUC: 0.858 vs. 0.814 and C-index: 0.826 vs. 0.801) based on OS in this patient population (Figure 2). Regarding the PFS, SIRI-PI also surpassed the NCCN-IPI with superior AUC (0.766 vs 0.709) and C-index (0.736 vs. 0.709) in discrimination. Conclusion: The results of this retrospective analysis suggested that the pretreatment SIRI was a potent and independent prognostic indicator that may be a potential candidate for identifying patients with poor prognosis in the future clinical practice of PGI-DLBCL. Keywords: Aggressive lymphoma, Clinically relevant, Systemic inflammation response index Figure 1 Figure 1. Disclosures No relevant conflicts of interest to declare.

Undergraduate student’s misconception about projectile motion after learning physics during the Covid-19 pandemic era

This research aimed to describe undergraduate students’ misconception about projectile motion after learning physics during the Covid-19 pandemic era. This research was qualitative research with a descriptive method. The subjects were 52 first-year undergraduate students who took physics courses. Data collecting methods used in this research were a test, questionnaires, and interviews. The test was taken from Physics by Giancoli with an additional question about certainty of response index (CRI). Data from the test were analyzed by categorizing it into lack of knowledge, knowledge of correct concepts, and misconception while open-ended questionnaires and interviews were used to help to clarify the condition. The test results indicated that 5.13% of students in lack knowledge, 28.85% the knowledge of correct concepts, and 66.02% in misconception. The questionnaire responses showed that students learned physics via online meeting with direct instruction model and ask-answer method, exercised with only applied problem (C3), and virtual practicum. The interviews showed that only a few of the students learned physics and responded to the lecturer during the online meeting. The results are that the majority of first-year undergraduate students are in misconception after learning physics during the Covid-19 pandemic era and need remedial learning about projectile motion.