Viscosity of binary mixtures of 2-ethoxyethanol with ethylene glycol, diethylene glycol, triethylene glycol and tetraethylene glycol systems atT=(293.15, 298.15 and 303.15) K

2009 ◽  
Vol 47 (1) ◽  
pp. 84-94 ◽  
Author(s):  
Cezary M. Kinart ◽  
Magdalena Klimczak ◽  
Marta Maj
Keyword(s):  
Ethylene Glycol ◽  
Binary Mixtures ◽  
Diethylene Glycol ◽  
Triethylene Glycol ◽  
Tetraethylene Glycol

THE ACTIVATION OF PURIFIED HUMAN PLASMINOGEN IN SOLUTIONS OF ETHYLENE GLYCOLS

1963 ◽  
Vol 41 (1) ◽  
pp. 889-895 ◽  
Author(s):  
Phyllis S. Roberts
Keyword(s):  
Methyl Ester ◽  
Ethylene Glycol ◽  
Diethylene Glycol ◽  
Room Temperature ◽  
Fast Rate ◽  
Triethylene Glycol ◽  
Ethylene Glycols ◽  
Human Plasminogen ◽  
Glycol Solution ◽  
Rate Of Accumulation

Ethylene glycols have been found to allow activation of purified preparations of human plasminogen. The activity of the enzyme formed, plasmin, was measured using TAMe (p-toluene-sulphonyl-L-arginine methyl ester) as a substrate. In 50% (v/v) solutions of these compounds at pH 7.6 and 30 °C, plasmin accumulated faster in diethylene and triethylene glycols than in glycerol, but in ethylene glycol no plasmin was found. When lower concentrations of ethylene glycol (from zero to 50%) and shorter times of incubation were used, plasmin was found. With equimolar solutions (4.3 M) of glycerol and the three glycols, only diethylene glycol showed a fast rate of accumulation of plasmin. A 50% triethylene glycol solution partially inhibited the rate of spontaneous activation but stabilized the plasmin formed and therefore enzyme accumulated. At room temperature more plasmin accumulated than at higher temperatures when plasminogen was incubated in 50% triethylene glycol solution, and no plasmin was found when plasminogen was incubated at pH 7.6, 30 °C, in 50% solutions of propylene glycols, several ethers of the ethylene glycols, several polymers of various glycols, and dioxane.

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