Role of the fractalkine receptor CX3CR1 polymorphisms V249I and T280M as risk factors for early‐onset coronary artery disease in patients with no classic risk factors

2008 ◽  
Vol 68 (4) ◽  
pp. 286-291 ◽  
Author(s):  
B. A. Nassar ◽  
A. A. Nanji ◽  
T. P. Ransom ◽  
K. Rockwood ◽  
S. A. Kirkland ◽  
...  
Keyword(s):  
Risk Factors ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Early Onset ◽  
Fractalkine Receptor ◽  
Artery Disease ◽  
Receptor Cx3cr1

scholarly journals Risk Factors for Long-term Outcome of Drug-eluting Stenting in Adults with Early-onset Coronary Artery Disease

2014 ◽  
Vol 11 (7) ◽  
pp. 721-725 ◽  
Author(s):  
Guipeng An ◽  
Zhongqi Du ◽  
Xiao Meng ◽  
Tao Guo ◽  
Guishuang Li ◽  
...  
Keyword(s):  
Risk Factors ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Early Onset ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Drug Eluting ◽  
Artery Disease

Serum chromium and angiographically determined coronary artery disease.

1978 ◽  
Vol 24 (4) ◽  
pp. 541-544 ◽  
Author(s):  
H A Newman ◽  
R F Leighton ◽  
R R Lanese ◽  
N A Freedland
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Plaque Formation ◽  
Atheromatous Plaque ◽  
Lower Serum ◽  
Serum Chromium ◽  
Artery Disease

Abstract Human aortas sampled from populations where there is little advanced atheromatous plaque formation contain higher concentrations of chromium than do aortas from populations in which atheromatosis is prevalent. In the present study serum cholesterol, triacylglycerols, and chromium (Cr3+) concentrations were measured in 32 subjects in whom coronary artery disease was assessed by cineangiography. The distribution of subjects with diseased and normal arteries overlapped below 5.50 microgram of chromium per liter. Only subjects free of coronary artery disease had chromium concentrations greater than or equal to 5.50 microgram/liter. The role of chromium was assessed in the context of the selected risk factors: cholesterol, triacylglycerols, and systolic and diastolic blood pressure. The group with coronary artery disease had significantly lower serum chromium concentrations than did the group with normally patent arteries.

scholarly journals The Effect of ACE I/D Polymorphisms Alone and With Concomitant Risk Factors on Coronary Artery Disease

2016 ◽  
Vol 24 (1) ◽  
pp. 157-163 ◽  
Author(s):  
Ahmed Amara ◽  
Meriem Mrad ◽  
Aicha Sayeh ◽  
Dhaker Lahideb ◽  
Samy Layouni ◽  
...  
Keyword(s):  
Risk Factors ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Polymerase Chain Reaction Amplification ◽  
Control Group ◽  
Mortality And Morbidity ◽  
Tunisian Patients ◽  
Traditional Risk Factors ◽  
Artery Disease

Background: Coronary artery disease (CAD), also known as atherosclerotic heart disease, is a leading cause of mortality and morbidity throughout the world. The role of insertion/deletion (I/D) polymorphisms of the angiotensin-converting enzyme (ACE) gene in the etiology of CAD remains to be more completely clarified. The aim of this study was to determine the role of the ACE I/D polymorphism in patients with CAD and to study the association together with traditional risk factors in assessing the risk of CAD. Methods: Our study population included 145 Tunisian patients with symptomatic CAD and a control group of 300 people matched for age and sex. All participants in the study were genotyped for the ACE I/D polymorphisms obtained by polymerase chain reaction amplification on genomic DNA. Results: Our analysis showed that the ACE D allele frequency ( P < 10−3; odds ratio [OR] = 5.2; 95% confidence interval [CI] = 3.6-7.6) and DD genotype ( P < 10−3; OR = 6.8; 95% CI = 4.4-10) are significantly more prevalent among patients with CAD than in controls and may be predisposing to CAD. We further found that the risk of CAD is greatly potentiated by several concomitant risk factors (smoking, diabetes, hypertension, dyslipidemia, and a family history of CAD). Conclusion: The ACE D allele may be predictive in individuals who may be at risk of developing CAD. Further investigations of these polymorphisms and their possible synergisms with traditional risk factors for CAD could help to ascertain better predictability for CAD susceptibility.

Multifactor dimensionality reduction analysis of MTHFR, PAI-1, ACE, PON1, and eNOS gene polymorphisms in patients with early onset coronary artery disease

2011 ◽  
Vol 18 (6) ◽  
pp. 803-809 ◽  
Author(s):  
M Agirbasli ◽  
AI Guney ◽  
HS Ozturhan ◽  
D Agirbasli ◽  
K Ulucan ◽  
...  
Keyword(s):  
Risk Factors ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Dimensionality Reduction ◽  
Early Onset ◽  
Multifactor Dimensionality Reduction ◽  
Gene Polymorphisms ◽  
Enos Gene ◽  
Artery Disease ◽  
Conventional Risk Factors

Background: Association studies in the Turkish population have investigated the single locus effects of different gene polymorphisms on coronary artery disease (CAD). CAD is a complex polygenic disease that involves complex interactions among multiple genetic and environmental conditions. Design: We evaluated associations of five candidate genetic polymorphisms (methylene tetrahydrofolate reductase C677T, plasminogen activator inhibitor 4G/5G, endothelial nitric oxide synthase (eNOS) 3–27 base pair repeat, insertion, or deletion of a 287 bp Alu repeat sequence polymorhism of angiotensin I converting enzyme, and paraoxonase Gln192Arg PON1 polymorphisms) with the presence and extent of early onset CAD. Methods: DNA was isolated and amplified from 90 consecutive patients with angiographically proven early onset CAD (ages 41 ± 5 for men, 49 ± 7 for women) and also from 90 control subjects with no significant coronary obstruction angiographically (ages 42 ± 5 for men, 48 ± 6 for women). Multifactor dimensionality reduction (MDR) analysis was performed to identify a model of CAD based on both genetic and conventional risk factors. Results: MDR analysis detected a significant model with four genes (prediction success ∼ 61%, p = 0.03). When the total number of the conventional risk factors is analysed with the candidate polymorphisms, a different model is identified that includes three of the four genes from the above model and achieves a similar prediction of CAD as the gene only model. Conclusion: These data indicate that gene–gene and gene–environmental risk interactions form significant models in predicting early onset CAD.

scholarly journals Pre-infarction angina – a problem more common than one might think. Role of general practitioners according to the 2019 ESC Clinical Practice Guidelines

2020 ◽  
Vol 16 (4) ◽  
pp. 389-395
Author(s):  
Małgorzata Wojciechowska ◽  
Keyword(s):  
Risk Factors ◽  
Myocardial Infarction ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
St Segment Elevation ◽  
Segment Elevation Myocardial Infarction ◽  
St Segment ◽  
Artery Disease ◽  
Test Probability

Background and aims: Some patients present with stenocardial pain long before the onset of myocardial infarction. The aim of the study was to evaluate the mean frequency and duration of typical angina pectoris preceding ST-segment elevation myocardial infarction. In addition, the article addresses the role of general practitioners in the diagnosis of patients with suspected coronary artery disease. Material and methods: The study included a total of 120 patients without prior diagnosis of coronary artery disease who were admitted to the invasive cardiology department with ST-segment elevation myocardial infarction. All patients were assessed to determine symptoms preceding myocardial infarction and risk factors for coronary artery disease. In addition, their pre-test probability of disease was estimated. Results: Out of 120 patients, 43 (35.8%) presented with typical angina symptoms preceding myocardial infarction. The median duration of symptoms was 45 days (min 4, max 2,190 days!), and symptoms recurring for ≥2 weeks were found in 35 patients. The estimated pre-test probability of coronary artery disease was >15% in 40 (93%) patients, and the risk factors for coronary artery disease were prevalent. Conclusions: Typical exertional angina preceding myocardial infarction occurred in over 35% of patients. In some of them, it persisted for a number of months. The estimated probability of coronary artery disease in nearly all patients was >15%. Based on the collected data, the authors conclude that there is a need for broadly understood education so as to improve the understanding of typical anginal symptoms. Correct recognition of symptoms by physicians and patients can significantly reduce the incidence of myocardial infarction and, consequently, bring down the prevalence of heart failure, and decrease mortality rates in patients with coronary artery disease.

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