A Study on Analysis of Labeling Efficiency Depending on Mixing Time in Asan Medical Center Red Blood Cell Labeling Method

AbstractThe objective of this single-center retrospective cohort study was to investigate the relationship between blood transfusion and persistent inflammation, immunosuppression, and catabolism syndrome (PIICS). The study was conducted at the Critical Care Center at Toho University Omori Medical Center, Japan. We included 391 patients in the PIICS group (hospitalization for > 15 days, C-reactive protein > 3.0 mg/dL or albumin < 3.0 mg/dL or lymph < 800/μL on day 14) and 762 patients in the non-PIICS group (hospitalization for > 15 days and not meeting the PIICS criteria). We performed univariate and multivariate logistic regression analyses using PIICS as the objective variable and red blood cell (RBC) or fresh frozen plasma or platelet (PLT) transfusion and other confounding factors as explanatory variables. In addition, we conducted a sensitivity analysis using propensity score matching analysis. The multivariate and propensity score analyses showed that RBC and PLT transfusions were significantly associated with PIICS. This is the first study to report an association between RBC and PLT transfusions and PIICS. Our findings have contributed to better understanding the risk factors of PIICS and suggest that physicians should consider the risk of PIICS occurrence when administering blood transfusions in intensive care unit (ICU) patients.

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Clinical Application of Spontaneous Red Blood Cell Labeling With Tc-99m Sodium Pertechnetate

Clinical Nuclear Medicine ◽

10.1097/00003072-199410000-00012 ◽

1994 ◽

Vol 19 (10) ◽

pp. 895-897

Author(s):

TATSUROU KAMINAGA ◽

TSUNEHIKO NISHIMURA ◽

KOUHEI HAYASHIDA ◽

YOSHIO ISHIDA ◽

MASAHIKO HIROKI

Keyword(s):

Blood Cell ◽

Clinical Application ◽

Red Blood Cell ◽

Cell Labeling ◽

Sodium Pertechnetate

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Actively circulating blood volume in endotoxin shock measured by indicator dilution

AJP Heart and Circulatory Physiology ◽

10.1152/ajpheart.1979.236.2.h291 ◽

1979 ◽

Vol 236 (2) ◽

pp. H291-H300 ◽

Cited By ~ 2

Author(s):

C. F. Rothe ◽

R. H. Murray ◽

T. D. Bennett

Keyword(s):

Blood Cell ◽

Blood Volume ◽

Red Blood Cell ◽

Mixing Time ◽

Volume Of Distribution ◽

Endotoxin Shock ◽

Circulating Blood Volume ◽

Arterial Blood ◽

Concentration Changes ◽

Volumes Of Distribution

To estimate the size of the actively circulating blood volume of splenectomized dogs during control conditions and after endotoxin infusion, the pattern of concentration changes of 51Cr-labeled erythrocytes and 125I-labeled albumin was monitored. A dual exponential equation was fitted to the data. The total red blood cell and albumin volumes of distribution were determined from the slow exponential disappearance curves. The active red blood cell and albumin volumes were 89.8 +/- 5.3% and 92.0 +/- 2.0% of the total volumes, respectively. After endotoxin shock (mean arterial blood pressure 49.1 +/- 17.8 mmHg) the active volumes fell to only 60.0 +/- 10.3% and 56.2 +/- 20.0% of the total volumes, respectively. The fast-mixing time constants were similar (3.1 +/- 1.4 min and 2.5 +/- 2.7 min, respectively) and did not change significantly during the endotoxin shock, indicating that the albumin tag mixed into its larger volume of distribution as rapidly as the cells mixed into their indicated volume. We conclude that 1) an active blood volume can be distinguished, 2) it decreases for both red blood cells and albumin in endotoxin shock, and 3) a major part of the "extravascular plasma volume," as estimated by albumin dilution, is in the actively circulating circulation.

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A new 99mTc-red blood cell labeling procedure for cardiac blood pool imaging: clinical results

European Journal of Nuclear Medicine ◽

10.1007/bf00449219 ◽

1989 ◽

Vol 15 (7) ◽

pp. 333-335 ◽

Cited By ~ 11

Author(s):

Henning Kelb�k ◽

Kirsten B�low ◽

Jan Aldershvile ◽

Jens M�gelvang ◽

Steen Levin Nielsen

Keyword(s):

Blood Cell ◽

Red Blood Cell ◽

Clinical Results ◽

Blood Pool ◽

Cell Labeling ◽

Blood Pool Imaging ◽

Cardiac Blood ◽

Cardiac Blood Pool

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A STUDY OF THE COMPARATIVE ABILITY OF STANNOUS CHLORIDE FORMULATED WITH EITHER EHDP OR PYROPHOSPHATE TO PROMOTE RED BLOOD CELL LABELING WITH Tc99m

Clinical Nuclear Medicine ◽

10.1097/00003072-198210001-00007 ◽

1982 ◽

Vol 7 (supplement) ◽

pp. P64

Author(s):

B. F. Van Duzee ◽

J. A. Schaefer ◽

A. J. Tofe ◽

M. C. Gerson ◽

C. Williams ◽

...

Keyword(s):

Blood Cell ◽

Red Blood Cell ◽

Stannous Chloride ◽

Cell Labeling

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Pitfall to Modified In Vivo Method of Technetium-99m Red Blood Cell Labeling

Clinical Nuclear Medicine ◽

10.1097/00003072-198312000-00001 ◽

1983 ◽

Vol 8 (12) ◽

pp. 585-587 ◽

Cited By ~ 13

Author(s):

JAMES L. TATUM ◽

TIMOTHY S. BURKE ◽

JERRY I. HIRSCH ◽

WILLIAM W. MILLER ◽

MELVIN J. FRATKIN

Keyword(s):

Blood Cell ◽

Red Blood Cell ◽

Cell Labeling ◽

Technetium 99M

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Association of Red Blood Cell and Platelet Transfusions With Persistent Inflammation, Immunosuppression, and Catabolism Syndrome in Critically Ill Patients

10.21203/rs.3.rs-869129/v1 ◽

2021 ◽

Author(s):

Ginga Suzuki ◽

Ryo Ichibayashi ◽

Yuka Masuyama ◽

Saki Yamamoto ◽

Hibiki Serizawa ◽

...

Keyword(s):

Propensity Score ◽

Blood Cell ◽

Red Blood Cell ◽

Medical Center ◽

Care Center ◽

Fresh Frozen Plasma ◽

Explanatory Variables ◽

Propensity Score Matching Analysis ◽

Persistent Inflammation ◽

Fresh Frozen

Abstract The objective of this single-center retrospective cohort study was to investigate the relationship between blood transfusion and persistent inflammation, immunosuppression, and catabolism syndrome (PIICS). The study was conducted at the Critical Care Center at Toho University Omori Medical Center, Japan. We included 391 patients in the PIICS group (hospitalization for > 15 days, C-reactive protein > 3.0 mg/dL or albumin < 3.0 mg/dL or lymph < 800/µL on day 14) and 762 patients in the non-PIICS group (hospitalization for > 15 days and not meeting the PIICS criteria). We performed univariate and multivariate logistic regression analyses using PIICS as the objective variable and red blood cell (RBC) or fresh frozen plasma or platelet (PLT) transfusion and other confounding factors as explanatory variables. In addition, we conducted sensitivity analysis using propensity score matching analysis. The multivariate and propensity score analyses showed that RBC and PLT transfusions were significantly associated with PIICS. This is the first study to report an association between RBC and PLT transfusions and PIICS. Our findings have contributed to better understanding the risk factors of PIICS and suggest that physicians should consider the risk of PIICS occurrence when administering blood transfusions in intensive care unit (ICU) patients.

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Reduced Packed Red Blood Cell Utilization Via Implementation of Transfusion Guidelines in a Large Health System Hospital

Blood ◽

10.1182/blood-2019-124193 ◽

2019 ◽

Vol 134 (Supplement_1) ◽

pp. 3451-3451

Author(s):

Reid Christian Bowers ◽

Michael A. Thompson ◽

Julie Van Dreser ◽

Federico Augusto Sanchez

Keyword(s):

Blood Cell ◽

Health System ◽

Board Of Directors ◽

Red Blood Cell ◽

Research Funding ◽

Medical Center ◽

Further Education ◽

Advisory Committees ◽

Transfusion Guidelines ◽

Individual Clinician

Background: We have previously discussed how implementation of Patient Blood Management (PBM) principles such as transfusion guidelines helped reduce packed red blood cell (PRBC) usage in cardiovascular surgery patients (Bowers et al, Reduced Blood Product Utilization via Implementation of an Anemia Clinic and Consult Service in a Large Health System Hospital https://tinyurl.com/y3ucr3sz). We now discuss the effect of implementing transfusion guidelines on PRBC transfusion practices at an institutional level at St. Luke's Medical Center, Advocate Aurora Health in Milwaukee, WI. Methods: Beginning in 2015 Aurora Health Care made 7 g/dL the standard threshold below which packed red blood cell (PRBC) transfusion is considered appropriate. Additionally, transfusing PRBCs as single units with a hemoglobin (Hgb) measurement between each unit was made standard. Education was provided to clinicians on the new standard including best practice advice in the transfusion ordering workflow. Data was gathered on institutional PRBC use and individual clinician PRBC ordering practices. Further education was provided based on the extent to which data showed conformity to the new standard. Results: PBM implementation 2015-2018 was associated with a drop in institutional PRBC usage from 11,490 to 9301 units. The percentage of transfusions ordered with Hgb < 7 g/dL rose from 41.6% to 71.8%. The percentage of single unit orders increased from 67.3% to 91.8%. See Graph/Table 1 & 2 for further analysis of individual practitioner PRBC ordering. See Table 3 for reporting period volume data. Conclusions: Implementation of PRBC transfusion guidelines was associated with a greater than 2000-unit annual reduction in PRBC usage. Reduction was associated with individual clinician transfusion practices that increasingly conformed with guidelines over time. Disclosures Thompson: Adaptive: Membership on an entity's Board of Directors or advisory committees; AbbVie: Research Funding; UpToDate: Patents & Royalties: Myeloma reviewer; BMS: Research Funding; Celgene: Membership on an entity's Board of Directors or advisory committees; Lynx Bio: Research Funding; VIA Oncology: Membership on an entity's Board of Directors or advisory committees; GSK: Membership on an entity's Board of Directors or advisory committees; Doximity: Equity Ownership, Membership on an entity's Board of Directors or advisory committees; Takeda: Membership on an entity's Board of Directors or advisory committees, Research Funding.

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