TheIn VitroPermeability Coefficient and Short-Term Absorption Rates for Vinyl Toluene Using Human Cadaver Skin Mounted in a Static Diffusion Cell Model

2006 ◽  
Vol 29 (1) ◽  
pp. 39-55 ◽  
Author(s):  
William J. Fasano ◽  
Kevin N. Baer
Keyword(s):  
Cell Model ◽  
Human Cadaver ◽  
Diffusion Cell ◽  
Short Term ◽  
Human Cadaver Skin ◽  
Cadaver Skin

scholarly journals Transdermal delivery of FITC-Dextrans with different molecular weights using radiofrequency microporation

2020 ◽  
Vol 24 (1) ◽  
Author(s):  
Guk Young Ahn ◽  
Hae-Seok Eo ◽  
Dongwon Kim ◽  
Sung-Wook Choi
Keyword(s):  
Transdermal Delivery ◽  
Fluorescein Isothiocyanate ◽  
Optical Microscope ◽  
Human Cadaver ◽  
Diffusion Cell ◽  
Franz Diffusion Cell ◽  
Molecular Weights ◽  
Pig Skin ◽  
Human Cadaver Skin ◽  
Cadaver Skin

Abstract Background Transdermal delivery is of great importance for the effective delivery of bioactive or therapeutic agents into a body. The microporation device based on radiofrequency can be used to enhance delivery efficiency by removing the epidermis layer. Methods The micropores were developed on pig skin and human cadaver skin with dermal and epidermal layers by the microporation device. The regeneration of micropores in the human cadaver skin caused by microporation was confirmed using an optical microscope and haematoxylin/eosin (H&E) staining. The permeability of fluorescein isothiocyanate-dextrans (FITC-dextrans) with different molecular weights through the pig and human cadaver skins were measured using Franz diffusion cell. Results The optical image and histological analysis confirmed that the micropores on the skin were recovered over time. The enhanced permeability through micropores was confirmed by Franz diffusion cell. The lower molecular weight of FITC-dextran permeated more on both human and pig skin. In addition, the permeation rate was higher in pig skin than in human skin. Conclusions We believe that the microporation device can be used as a potential technique for effective transdermal drug delivery.

Rat epidermal keratinocyte organotypic culture (ROC) compared to human cadaver skin: The effect of skin permeation enhancers

2007 ◽  
Vol 30 (3-4) ◽  
pp. 240-250 ◽  
Author(s):  
Sari Pappinen ◽  
Sanna Tikkinen ◽  
Sanna Pasonen-Seppänen ◽  
Lasse Murtomäki ◽  
Marjukka Suhonen ◽  
...  
Keyword(s):  
Organotypic Culture ◽  
Skin Permeation ◽  
Human Cadaver ◽  
Permeation Enhancers ◽  
Epidermal Keratinocyte ◽  
Human Cadaver Skin ◽  
Cadaver Skin

scholarly journals Survival of human cadaver skin on severe combined immune deficiency pigs: Proof of concept

2019 ◽  
Vol 27 (4) ◽  
pp. 426-430 ◽  
Author(s):  
Adam J. Singer ◽  
Christopher Tuggle ◽  
Amanda Ahrens ◽  
Mary Sauer ◽  
Steve A. McClain ◽  
...  
Keyword(s):  
Immune Deficiency ◽  
Human Cadaver ◽  
Proof Of Concept ◽  
Severe Combined Immune Deficiency ◽  
Human Cadaver Skin ◽  
Cadaver Skin ◽  
Combined Immune Deficiency

Permeability and Retention Studies of (-)Epicatechin Gel Formulations in Human Cadaver Skin

2006 ◽  
Vol 32 (9) ◽  
pp. 1007-1017 ◽  
Author(s):  
J. Suppasrivasuseth ◽  
R. A. Bellantone ◽  
F. M. Plakogiannis ◽  
G. Stagni
Keyword(s):  
Human Cadaver ◽  
Human Cadaver Skin ◽  
Cadaver Skin ◽  
Gel Formulations

Morphology of glycerol-preserved human cadaver skin

Burns ◽  
1996 ◽  
Vol 22 (2) ◽  
pp. 113-116 ◽  
Author(s):  
C.D. Richters ◽  
M.J. Hoekstra ◽  
J. van Baare ◽  
J.S. du Pont ◽  
E.W.A. Kamperdijk
Keyword(s):  
Human Cadaver ◽  
Human Cadaver Skin ◽  
Cadaver Skin

Permeability of pure enantiomers of ketorolac through human cadaver skin

1995 ◽  
Vol 84 (8) ◽  
pp. 987-990 ◽  
Author(s):  
Samir D. Roy ◽  
Elizabeth Manoukian ◽  
Alan Divor ◽  
Dhruba J. Chatterjee
Keyword(s):  
Human Cadaver ◽  
Human Cadaver Skin ◽  
Cadaver Skin

Use of Skin Substitutes in Adult Canadian Burn Centres

1997 ◽  
Vol 5 (2) ◽  
pp. 112-117 ◽  
Author(s):  
Richard A Hopper ◽  
Judy Knighton ◽  
Joel Fish ◽  
Walter Peters
Keyword(s):  
United States ◽  
Donor Site ◽  
The United States ◽  
Human Cadaver ◽  
Research Development ◽  
Skin Substitutes ◽  
Private Companies ◽  
Pig Skin ◽  
Human Cadaver Skin ◽  
Cadaver Skin

Seventeen Canadian adult burn centres were surveyed to determine the pattern of use, cost and availability of nine skin substitutes. An equal number of centres in the United States with comparable bed capacities were approached for comparison. Eighty-eight per cent of the Canadian centres and 76% of the United States centres responded to the questionnaire. Human cadaver skin, pig skin and Biobrane were used by approximately twice as many United States centres as Canadian centres. Cultured epidermal autografts (CEAs) were used by 20% of the Canadian centres and 15% of the American centres. Opsite, Tegaderm and Duoderm were used widely in both countries. Alloderm was used only in the United States, and amnion was not used in either country. The most common use of each substitute varied among centres, however, the pattern of use was comparable between the two countries, with the exception that Biobrane was not used in Canada to cover donor site wounds. In the United States, 60% of cadaver skin and all CEAs were purchased from private companies, whereas use of these two relatively expensive skin substitutes in Canada was restricted to centres with access to hospital-affiliated skin banks or laboratories. With the dependence of Canadian centres on noncommercial sources of biological skin replacements, research development in established skin banks should be encouraged, and regional discrepancies regarding access to these facilities addressed.

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