Response surface methodology for optimization and determination of Riluzole by microfunnel magnetic stirring-assisted liquid–liquid microextraction coupled with high-performance liquid chromatography

2018 ◽  
Vol 53 (18) ◽  
pp. 2926-2934
Author(s):  
Mitra Tohidi ◽  
Majid Ramezani ◽  
Ali Mehramizi
Keyword(s):  
Response Surface Methodology ◽  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
Response Surface ◽  
High Performance ◽  
Magnetic Stirring ◽  
Liquid Microextraction

Dispersive liquid–liquid microextraction for preconcentration and determination of phenytoin in real samples using response surface methodology-high performance liquid chromatography

RSC Advances ◽  
2014 ◽  
Vol 4 (107) ◽  
pp. 62190-62196 ◽  
Author(s):  
Eslam Pourbasheer ◽  
Samira Sadafi ◽  
Mohammad Reza Ganjali ◽  
Maryam Abbasghorbani
Keyword(s):  
Response Surface Methodology ◽  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
Response Surface ◽  
High Performance ◽  
Real Samples ◽  
Dispersive Liquid Liquid Microextraction ◽  
Liquid Microextraction

In the present study, dispersive liquid–liquid microextraction (DLLME) was developed for preconcentration and determination of phenytoin in real samples by high performance liquid chromatography (HPLC).

Determination of Verapamil in Exhaled Breath Condensate by Using Microextraction and Liquid Chromatography

2019 ◽  
Vol 15 (5) ◽  
pp. 535-541 ◽  
Author(s):  
Fariba Pourkarim ◽  
Ali Shayanfar ◽  
Maryam Khoubnasabjafari ◽  
Fariborz Akbarzadeh ◽  
Sanaz Sajedi-Amin ◽  
...  
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
High Performance ◽  
Exhaled Breath Condensate ◽  
Exhaled Breath ◽  
Good Precision ◽  
Dispersive Liquid Liquid Microextraction ◽  
Breath Condensate ◽  
Liquid Microextraction

Background:Developing a simple analysis method for quantification of drug concentration is one of the essential issues in pharmacokinetic and therapeutic drug monitoring studies.Objective:A fast and reliable dispersive liquid-liquid microextraction procedure was employed for preconcentration of verapamil in exhaled breath condensate (EBC) samples and this was followed by the determination with high-performance liquid chromatography-ultraviolet detection.Methods:A reverse-phase high-performance liquid chromatography (RP-HPLC) combined with a dispersive liquid-liquid microextraction method (DLLME) was applied for quantification of verapamil in the EBC samples. The developed method was validated according to FDA guidelines.Results:Under the optimum conditions, the method provided a linear range between 0.07 and 0.8 µg.mL-1 with a coefficient of determination of 0.998. The intra- and inter-day relative standard deviation and relative error values of the method were below 15%, which indicated good precision and accuracy. The proposed method was successfully applied for the analysis of verapamil in two real samples with concentrations of 0.07 and 0.09 µg.mL-1.Conclusion:The established HPLC-UV-DLLME method could be applied for the analysis of verapamil in human EBC samples.

Sign in / Sign up

Export Citation Format

Share Document