This paper deals with the problem of mixed H2/H∞ control for Itô-type stochastic time-delay systems. First, the H2/H∞ control problem for stochastic time-delay systems is presented, which considers the mean square stability, H2 control performance index, and the ability of disturbance attenuation of the closed-loop systems. Second, by choosing an appropriate Lyapunov–Krasoviskii functional and using matrix inequality technique, some sufficient conditions for the existence of state feedback H2/H∞ controller for stochastic time-delay systems are obtained in the form of linear matrix inequalities. Third, two convex optimization problems with linear matrix inequality constraints are formulated to design the optimal mixed H2/H∞ controller which minimizes the guaranteed cost of the closed-loop systems with known and unknown initial functions, and the corresponding algorithm is given to optimize H2/H∞ performance index. Finally, a numerical example is employed to show the effectiveness and feasibility of the proposed method.