Long term administration of low doses of mycotoxins in poultry. 2. Residues of ochratoxin A and aflatoxins in broilers and laying hens after combined administration of ochratoxin A and aflatoxin B1

Thirty five patients with severe evolutive arteriopathy were selected since following the advent of their first accident and although they received classical treatment they experienced at least one or sometimes several relapses of thrombosis. These patients were subjected to discontinuous subcutaneous ambulatory heparin treatment. This treatment consisted of two daily injections of 5,000–10,000 IU calcium-heparin (Calciparine) depending on each patient’s weight, during 30 days every three months. A backward survey of nine years for the patients first treated and of over two years for those most recently examined indicated that such patients never underwent recurrence of the disease and were considerably functionally improved. Experimentally in the animal and after subcutaneous injection of low doses of using 35s labeled heparin we have shown that heparin remains bound both on arterial and venous endothelium at least 15 hours after all anticoagulant activity has disappeared from circulating blood. As a rule and depending on individuals the relationship between the dose and the persistence of heparin bound on the wall is much more constant than that existing between the dose and the duration of the anticoagulant effect. Low doses (100-150 IU/kg in man) repeated twice a day will suffice to ensure the persistence of an endothelial coating. This coating could account for the excellent clinical results obtained.

Download Full-text

Effect of Zinc or S-Adenosyl-l-methionine on Long Term Administration of Low Doses of Lead to Rats

Pharmacology & Toxicology ◽

10.1111/j.1600-0773.1993.tb01562.x ◽

1993 ◽

Vol 73 (4) ◽

pp. 189-191 ◽

Cited By ~ 1

Author(s):

Juan J. Muñoz ◽

Cristina Roca ◽

José L. Santos ◽

Miguel Arroyo ◽

Rafael E. Salamanca

Keyword(s):

Low Doses ◽

Term Administration

Download Full-text

Effects of individual and combined administration of ochratoxin A and aflatoxin B1 in tissues and eggs of White Leghorn breeder hens

Journal of the Science of Food and Agriculture ◽

10.1002/jsfa.4740 ◽

2011 ◽

Vol 92 (7) ◽

pp. 1540-1544 ◽

Cited By ~ 18

Author(s):

Zahoor Ul Hassan ◽

Muhammad Z Khan ◽

Ahrar Khan ◽

Ijaz Javed ◽

Zahid Hussain

Keyword(s):

Ochratoxin A ◽

Aflatoxin B1 ◽

White Leghorn ◽

Breeder Hens ◽

Combined Administration

Download Full-text

Torasemide: additional benefits for postmenopausal women with arterial hypertension

Systemic Hypertension ◽

10.26442/sg28956 ◽

2013 ◽

Vol 10 (2) ◽

pp. 9-13 ◽

Cited By ~ 1

Author(s):

O N Tkacheva ◽

N K Runikhina ◽

N V Sharashkina

Keyword(s):

Clinical Practice ◽

Arterial Hypertension ◽

Postmenopausal Women ◽

Antihypertensive Effect ◽

Low Doses ◽

Electrolyte Metabolism ◽

Renin Angiotensin Aldosterone System ◽

Low Renin Hypertension ◽

Term Administration

Effective and safe diuretic torasemide has additional effects of renin-angiotensin-aldosterone system blockage. Torasemide can be used as monotherapy or combined with other antihypertensives. In low doses torasemide produces pronounced antihypertensive effect without augmentation of excretion of potassium and water with urine. Long-term administration of torasemide was not associated with significant effects on lipid, purine, carbohydrate, or electrolyte metabolism parameters. Torasemide particularly effective in postmenopausal women, as these women are more likely formed low-renin hypertension. Therefore, torasemide can be used more widely in modern clinical practice.

Download Full-text