Measuring gains in connected speech following treatment for word retrieval: a study with two participants with primary progressive aphasia

Aphasiology ◽  
2014 ◽  
Vol 29 (11) ◽  
pp. 1265-1288 ◽  
Author(s):  
Karen Croot ◽  
Cathleen Taylor ◽  
Stefanie Abel ◽  
Kelly Jones ◽  
Luisa Krein ◽  
...  
Keyword(s):  
Primary Progressive Aphasia ◽  
Word Retrieval ◽  
Connected Speech ◽  
Progressive Aphasia ◽  
Primary Progressive

scholarly journals The Effect of Word Retrieval Therapy in Primary Progressive Aphasia: A Single-Case Study

2018 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Salime Jafari ◽  
Ahmad Reza Khatoonabadi ◽  
Maryam Noroozian ◽  
Azar Mehri ◽  
Hassan Ashayeri ◽  
...  
Keyword(s):  
Single Case ◽  
Primary Progressive Aphasia ◽  
Word Retrieval ◽  
Single Case Study ◽  
Progressive Aphasia ◽  
Primary Progressive

Making the Right Connections: Maximizing Lexical Generalization in Lexical Impairments in Primary Progressive Aphasia and Alzheimer's Disease

2021 ◽  
pp. 1-16
Author(s):  
Ashleigh Beales ◽  
Anne Whitworth ◽  
Jade Cartwright ◽  
Peter K. Panegyres ◽  
Robert T. Kane
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Family Members ◽  
Primary Progressive Aphasia ◽  
Lexical Retrieval ◽  
Connected Speech ◽  
Progressive Aphasia ◽  
Primary Progressive ◽  
Word Classes ◽  
The Impact

Purpose Positive intervention effects following lexical retrieval interventions are increasingly reported with people with progressive language impairments; however, generalization of therapy gains are less frequently evident and less well understood. This study sought to explore the impact of specific therapy ingredients on generalization outcomes. Method Twelve participants with progressive lexical retrieval deficits (four each with semantic variant primary progressive aphasia, logopenic variant primary progressive aphasia, and Alzheimer's disease, amnestic presentation) and their family members participated in a 6-week intervention that aimed to increase access to different word classes (nouns, verbs, and adjectives) through a strategic self-cueing approach. Generalization was actively facilitated through strategy practice in connected speech. Repeated baselines of picture naming and connected speech were conducted prior to intervention and repeated immediately post and at 6 weeks following intervention. Results All three diagnostic groups showed significant improvements in naming performance post-intervention for all word classes and for both treated and untreated items, demonstrating consistent treatment effectiveness and generalization at the word level. No changes in the informativeness or efficiency of connected speech were found. Conclusions Despite heterogeneity across participants, widespread evidence of both treatment effects and generalization to untreated items was found for all diagnostic groups and word classes. The consistent within-level generalization across all groups is explored here in relation to optimization of strategy use through incorporation of cognitive scaffolds, strategic practice at the connected speech level, and the inclusion of family members. The absence of across-level generalization to connected speech is also explored. Supplemental Material https://doi.org/10.23641/asha.14219771

Quantifying Fluency of Connected Speech with a Brief Protocol in Primary Progressive Aphasia (P02.045)

Neurology ◽  
2012 ◽  
Vol 78 (Meeting Abstracts 1) ◽  
pp. P02.045-P02.045
Author(s):  
S. Ash ◽  
E. Evans ◽  
J. O'Shea ◽  
A. Boller ◽  
L. Burkholder ◽  
...  
Keyword(s):  
Primary Progressive Aphasia ◽  
Connected Speech ◽  
Progressive Aphasia ◽  
Primary Progressive

scholarly journals Speech Metrics and Samples That Differentiate Between Nonfluent/Agrammatic and Logopenic Variants of Primary Progressive Aphasia

2021 ◽  
pp. 1-22
Author(s):  
Katarina L. Haley ◽  
Adam Jacks ◽  
Jordan Jarrett ◽  
Taylor Ray ◽  
Kevin T. Cunningham ◽  
...  
Keyword(s):  
Large Scale ◽  
Primary Progressive Aphasia ◽  
Diagnostic Tools ◽  
Future Research ◽  
Apraxia Of Speech ◽  
Connected Speech ◽  
Progressive Aphasia ◽  
Primary Progressive ◽  
Syllable Duration ◽  
Semantic Variant

Purpose Of the three currently recognized variants of primary progressive aphasia, behavioral differentiation between the nonfluent/agrammatic (nfvPPA) and logopenic (lvPPA) variants is particularly difficult. The challenge includes uncertainty regarding diagnosis of apraxia of speech, which is subsumed within criteria for variant classification. The purpose of this study was to determine the extent to which a variety of speech articulation and prosody metrics for apraxia of speech differentiate between nfvPPA and lvPPA across diverse speech samples. Method The study involved 25 participants with progressive aphasia (10 with nfvPPA, 10 with lvPPA, and five with the semantic variant). Speech samples included a word repetition task, a picture description task, and a story narrative task. We completed acoustic analyses of temporal prosody and quantitative perceptual analyses based on narrow phonetic transcription and then evaluated the degree of differentiation between nfvPPA and lvPPA participants (with the semantic variant serving as a reference point for minimal speech production impairment). Results Most, but not all, articulatory and prosodic metrics differentiated statistically between the nfvPPA and lvPPA groups. Measures of distortion frequency, syllable duration, syllable scanning, and—to a limited extent—syllable stress and phonemic accuracy showed greater impairment in the nfvPPA group. Contrary to expectations, classification was most accurate in connected speech samples. A customized connected speech metric—the narrative syllable duration—yielded excellent to perfect classification accuracy. Discussion Measures of average syllable duration in multisyllabic utterances are useful diagnostic tools for differentiating between nfvPPA and lvPPA, particularly when based on connected speech samples. As such, they are suitable candidates for automatization, large-scale study, and application to clinical practice. The observation that both speech rate and distortion frequency differentiated more effectively in connected speech than on a motor speech examination suggests that it will be important to evaluate interactions between speech and discourse production in future research.

Connected speech markers of amyloid burden in primary progressive aphasia

Cortex ◽  
2021 ◽  
Author(s):  
Antoine Slegers ◽  
Geneviève Chafouleas ◽  
Maxime Montembeault ◽  
Christophe Bedetti ◽  
Ariane E. Welch ◽  
...  
Keyword(s):  
Primary Progressive Aphasia ◽  
Amyloid Burden ◽  
Connected Speech ◽  
Progressive Aphasia ◽  
Primary Progressive

Abnormalities of connected speech in the non-semantic variants of primary progressive aphasia

Aphasiology ◽  
2012 ◽  
Vol 26 (10) ◽  
pp. 1219-1237 ◽  
Author(s):  
Seyed Ahmad Sajjadi ◽  
Karalyn Patterson ◽  
Michal Tomek ◽  
Peter J. Nestor
Keyword(s):  
Primary Progressive Aphasia ◽  
Connected Speech ◽  
Progressive Aphasia ◽  
Primary Progressive

Word retrieval therapies in primary progressive aphasia

Aphasiology ◽  
2014 ◽  
Vol 28 (8-9) ◽  
pp. 1038-1068 ◽  
Author(s):  
Regina Jokel ◽  
Naida L. Graham ◽  
Elizabeth Rochon ◽  
Carol Leonard
Keyword(s):  
Primary Progressive Aphasia ◽  
Word Retrieval ◽  
Progressive Aphasia ◽  
Primary Progressive

scholarly journals Speech production differences in English and Italian speakers with nonfluent variant PPA

Neurology ◽  
2020 ◽  
Vol 94 (10) ◽  
pp. e1062-e1072 ◽  
Author(s):  
Elisa Canu ◽  
Federica Agosta ◽  
Giovanni Battistella ◽  
Edoardo G. Spinelli ◽  
Jessica DeLeon ◽  
...  
Keyword(s):  
Gray Matter Volume ◽  
Primary Progressive Aphasia ◽  
Cross Sectional Study ◽  
Speech Impairment ◽  
Neuropsychological Battery ◽  
Connected Speech ◽  
Cross Sectional ◽  
Progressive Aphasia ◽  
Primary Progressive ◽  
Language Measures

ObjectiveTo understand whether the clinical phenotype of nonfluent/agrammatic primary progressive aphasia (nfvPPA) could present differences depending on the patient’s native language.MethodsIn this cross-sectional study, we analyzed connected speech samples in monolingual English (nfvPPA-E) and Italian speakers (nfvPPA-I) who were diagnosed with nfvPPA and matched for age, sex, and Mini-Mental State Examination scores. Patients also received a comprehensive neuropsychological battery. All patients and 2 groups of age-matched healthy controls underwent an MRI scan with 3D T1-weighted sequences. Connected speech measures and the other cognitive features were compared between patient groups. MRI variables, in terms of gray matter volume, were compared between each patient group and the corresponding controls.ResultsCompared to nfvPPA-E, nfvPPA-I had fewer years of education and shorter reported disease duration. The 2 groups showed similar regional atrophy compatible with clinical diagnosis. Patients did not differ in nonlanguage domains, comprising executive scores. Connected speech sample analysis showed that nfvPPA-E had significantly more distortions than nfvPPA-I, while nfvPPA-I showed reduced scores in some measures of syntactic complexity. On language measures, Italian speakers performed more poorly on syntactic comprehension.ConclusionsnfvPPA-E showed greater motor speech impairment than nfvPPA-I despite higher level of education and comparable disease severity and atrophy changes. The data also suggest greater grammatical impairment in nfvPPA-I. This study illustrates the need to take into account the possible effect of the individual's spoken language on the phenotype and clinical presentation of primary progressive aphasia variants.

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