Experimental autologous osteochondral plug transfer in the treatment of focal chondral defects: magnetic resonance imaging signs of technical success in sheep

2005 ◽  
Vol 46 (8) ◽  
pp. 875-880 ◽  
Author(s):  
M. Uhl ◽  
A. Lahm ◽  
T. A. Bley ◽  
J. Haberstroh ◽  
E. Mrosek ◽  
...  
2015 ◽  
Vol 40 (7) ◽  
pp. 1428-1433 ◽  
Author(s):  
Michael Hackl ◽  
Kilian Wegmann ◽  
Christian Ries ◽  
Tim Leschinger ◽  
Klaus Josef Burkhart ◽  
...  

2017 ◽  
Vol 30 (02) ◽  
pp. 143-152 ◽  
Author(s):  
Charles Ley ◽  
Kerstin Hansson ◽  
Lennart Sjöström ◽  
Martin Rapp

SummaryObjectives: To describe postoperative computed tomography (CT) and magnetic resonance imaging (MRI) findings in dogs with degenerative lumbosacral stenosis (DLSS) treated by dorsal laminectomy and partial discectomy.Methods: Prospective clinical case study of dogs diagnosed with and treated for DLSS. Surgical and clinical findings were described. Computed tomography and low field MRI findings pre- and postoperatively were described and graded. Clinical, CT and MRI examinations were performed four to 18 months after surgery.Results: Eleven of 13 dogs were clinically improved and two dogs had unchanged clinical status postoperatively despite imaging signs of neural compression. Vacuum phenomenon, spondylosis, sclerosis of the seventh lumbar (L7) and first sacral (S1) vertebrae endplates and lumbosacral intervertebral joint osteoarthritis became more frequent in postoperative CT images. Postoperative MRI showed mild disc extrusions in five cases, and in all cases contrast enhancing non-discal tissue was present. All cases showed contrast enhancement of the L7 spinal nerves both pre- and postoperatively and seven had contrast enhancement of the lumbosacral intervertebral joints and paraspinal tissue postoperatively. Articular process fractures or fissures were noted in four dogs.Clinical significance: The study indicates that imaging signs of neural compression are common after DLSS surgery, even in dogs that have clinical improvement. Contrast enhancement of spinal nerves and soft tissues around the region of disc herniation is common both pre- and postoperatively and thus are unreliable criteria for identifying complications of the DLSS surgery.Supplementary Material to this article is available online at https://doi.org/10.3415/VCOT-16-06-0096


2020 ◽  
Vol 15 (6) ◽  
pp. 1703-1717 ◽  
Author(s):  
Julien Freitag ◽  
Kiran Shah ◽  
James Wickham ◽  
Douglas Li ◽  
Cameron Norsworthy ◽  
...  

Aim: To evaluate the safety, pain, functional and structural improvements after autologous adipose-derived mesenchymal stem cell (ADMSC) therapy in combination with arthroscopic abrasion arthroplasty in focal chondral defects of the knee. Methods: Eight patients with a focal full thickness chondral defect of the knee underwent arthroscopic abrasion arthroplasty followed by postoperative intra-articular injections of autologous ADMSCs (50 × 106 ADMSCs at baseline and 6 months). Clinical outcome was assessed using numeric pain rating scale, Knee Injury and Osteoarthritis Outcome Score and the Western Ontario and McMaster Universities Osteoarthritis Index. Structural outcome was determined by magnetic resonance imaging. Outcome was assessed over 24 months. Results: No serious adverse events occurred. Participants observed clinically significant improvement in pain and function. Magnetic resonance imaging analysis showed cartilage regeneration with T2 mapping values comparable to hyaline cartilage. Conclusion: Arthroscopic abrasion arthroplasty in combination with intra-articular ADMSC therapy results in reproducible pain, functional and structural improvements with regeneration of hyaline-like cartilage. Trial registration number: ACTRN12617000638336


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