Cortical sensory and motor response in a patient whose hand has been replanted: One-year follow up with functional magnetic resonance imaging

Abstract Background Insomnia is among the most prevalent of the sleep-related disorders. Insomnia disorder is associated with a brain hyperarousal state manifested by abnormal regional brain activity and resting state functional connectivity. Acupuncture improves sleep quality and modulates the hyperarousal state; however, the underlying neurobiological basis for improved sleep quality is poorly understood. The purpose of this clinical trial is to study the efficacy of acupuncture in the treatment of insomnia disorder. In addition, the neural mechanism by which acupuncture affects insomnia disorder will be explored using resting-state functional magnetic resonance imaging (rs-fMRI) and neuropsychological parameters. Methods and design A randomized, patient- and assessor-blinded trial will be conducted. We will randomize (in a 1:1 ratio) 60 eligible patients with insomnia disorder into a real acupuncture group or a sham acupuncture group. Interventions will be administered three times per week over a 4-week period, with an 8-week follow-up period. The healthy control group will consist of 30 age- and sex-matched healthy individuals who sleep well without any treatment intervention. All participants will undergo neuropsychological and rs-fMRI evaluations. The change in Pittsburgh Sleep Quality Index (PSQI) scores is the primary outcome parameter. The secondary outcome parameters include the Hyperarousal scale (HAS), rs-fMRI measurements, the Fatigue scale-14 (FS-14), the Hamilton depression scale (HAMD), the Hamilton anxiety scale (HAMA), a sleep diary, and an actigraph. Assessment of all parameters will be performed at baseline, post-treatment, and during follow-up. Analyses will be implemented based on intention-to-treat. Discussion The study results will be used to clarify the effectiveness and elucidate the mechanism by which acupuncture improves sleep quality in patients with insomnia disorder. Trial registration Chinese Clinical Trials Register, ChiCTR1800015282. Registered on 20 March 2018.

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PC3 - 190 Impact of Functional Magnetic Resonance Imaging on Clinical Decision Making and Outcomes in Patients with Low Grade Gliomas

Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques ◽

10.1017/cjn.2016.386 ◽

2016 ◽

Vol 43 (S4) ◽

pp. S19-S20

Author(s):

E. Kosteniuk ◽

J.C. Lau ◽

J.F. Megyesi

Keyword(s):

Magnetic Resonance Imaging ◽

Decision Making ◽

Magnetic Resonance ◽

Functional Magnetic Resonance Imaging ◽

Fmri Data ◽

Low Grade ◽

Functional Magnetic Resonance ◽

Resonance Imaging ◽

The Impact

This study aims to evaluate the impact of preoperative functional magnetic resonance imaging (fMRI) on low grade glioma (LGG) patients’ outcomes and surgical planning. Methods In this retrospective matched cohort study of a single surgeon’s patients, we are comparing two groups of LGG patients (WHO grade II) based on exposure to fMRI. Sixteen LGG patients who underwent fMRI were selected, and 32 control (non-fMRI exposed) patients are being selected through propensity score matching from a pool of 764 brain tumour patients. To assess the impact of fMRI data on clinicians’ decision making process, neurosurgeons within a single centre are completing questionnaires regarding treatment options for each LGG fMRI patient based on clinical data and structural imaging before and after fMRI. Results Within the group of 16 LGG patients who have undergone fMRI studies over a 12-year period, most patients presented with seizures (81 percent), and most lesions were left-sided (81 percent) and frontal (75 percent). Patients underwent either craniotomy (50 percent), stereotactic biopsy (25 percent) or nonsurgically management (25 percent). In surgical patients, between presurgical assessment and eight week post-surgical follow-up, mean modified Rankin scale improved from 1.80 (sd 0.79) to 1.50 (sd 0.97). In our cohort, 5-year mortality was 12.5 percent (mean follow-up duration 5.46 years). Conclusions Data analysis is ongoing with plans to compare relevant patient demographics and outcomes, and to analyse questionnaires to elucidate how surgeons incorporate fMRI data into their therapeutic approach.

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Functional Magnetic Resonance Imaging Localization of Ictal Onset to a Dysplastic Cleft with Simultaneous Sensorimotor Mapping: Intraoperative Electrophysiological Confirmation and Postoperative Follow-up: Technical Note

Neurosurgery ◽

10.1097/00006123-199809000-00152 ◽

1998 ◽

Vol 43 (3) ◽

pp. 644-645

Author(s):

Roy A.E. Bakay

Keyword(s):

Magnetic Resonance Imaging ◽

Magnetic Resonance ◽

Functional Magnetic Resonance Imaging ◽

Technical Note ◽

Functional Magnetic Resonance ◽

Resonance Imaging

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Acupuncture for patients with insomnia disorder using resting-state functional magnetic resonance imaging: a protocol for a Randomised Controlled Trial

10.21203/rs.2.384/v3 ◽

2019 ◽

Author(s):

jing guo ◽

Siyi Yu ◽

Chunhong Liu ◽

Guiling Wang ◽

Bin li

Keyword(s):

Magnetic Resonance Imaging ◽

Magnetic Resonance ◽

Functional Magnetic Resonance Imaging ◽

Sleep Quality ◽

Resting State ◽

Acupuncture Group ◽

Functional Magnetic Resonance ◽

Resonance Imaging ◽

Insomnia Disorder

Abstract Background: Insomnia is among the most prevalent sleep-related disorders. Insomnia disorder is associated with a brain hyperarousal state manifested by abnormal regional brain activity and resting-state functional connectivity (rs-FC). Acupuncture improves sleep quality and modulates the hyperarousal state; however, the underlying neurobiological basis for improved sleep quality is poorly understood. The purpose of this clinical trial is to study the efficacy of acupuncture in the treatment of insomnia disorder. In addition, the neural mechanism by which acupuncture affects insomnia disorder will be explored utilizing resting-state functional magnetic resonance imaging (rs-fMRI) and neuropsychological parameters. Methods and Design: A randomized, patient-assessor-blinded trial will be conducted. We will randomize (1:1 ratio) 60 eligible patients with insomnia disorder into a real acupuncture group or a sham acupuncture group. Interventions will be administered three times per week over a 4 week period, with an 8 week follow-up period. The healthy control group will consist of 30 age- and sex-matched healthy good sleepers without any treatment intervention. All participants will undergo neuropsychological and rs-fMRI evaluations. The change of Pittsburgh Sleep Quality Index (PSQI) scores is the primary outcome parameter. The secondary outcome parameters include the Hyperarousal scale (HAS), rs-fMRI measurements, the Fatigue scale-14 (FS-14), the Hamilton depression scale (HAMD), the Hamilton anxiety scale (HAMA), a sleep diary, and an actigraph. Assessment of all parameters will be performed at baseline, post-treatment, and during follow-up. Analyses will be implemented based on intention-to-treat. Discussion: The study results will be utilized to clarify the effectiveness and elucidate the mechanism by which acupuncture improves sleep quality in patients with insomnia disorder.

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