The aim of this paper is to evaluate the larvicidal and ovicidal activities of hexane, diethyl ether, dichloromethane, ethyl acetate, and methanol extract of Indian medicinal plant, Clausena excavata, at different concentrations against lepidopteran agricultural field pest, Spodoptera litura (Lepidoptera: Noctuidae), and Aedes aegypti, Anopheles stephensi, and Culex quinquefasciatus (Diptera: Culicidae). Twenty-five early fourth instar larvae of S. litura and A. aegypti, An. stephensi and C. quinquefasciatus were exposed to various concentrations and were assayed in the laboratory by using specific protocols. The 24 h LC50 and LC90 values of the C. excavata leaf extract was determined by probit analysis. The ovicidal activity were determined against S. litura and A. aegypti, An. stephensi, and C. quinquefasciatus and was assessed 120 hrs after treatment. Results of this study show that the selected Indian medicinal plant C. excavata may be a potential source of natural larvicidal and ovicidal activities against selected pest and vector mosquitoes.