Reviewing research on the synthesis of CALB-catalyzed sugar esters incorporating systematic mapping principles

Author(s):  
Maria Carolina Pereira Gonçalves ◽  
João Paulo Romanelli ◽  
José Renato Guimarães ◽  
Ana Carolina Vieira ◽  
Bruna Pereira de Azevedo ◽  
...  
10.28945/4505 ◽  
2020 ◽  
Vol 15 ◽  
pp. 039-064
Author(s):  
Rogerio Ferreira da Silva ◽  
Itana Maria de Souza Gimenes ◽  
José Carlos Maldonado

Aim/Purpose: This paper presents a study of Virtual Communities of Practice (VCoP) evaluation methods that aims to identify their current status and impact on knowledge sharing. The purposes of the study are as follows: (i) to identify trends and research gaps in VCoP evaluation methods; and, (ii) to assist researchers to position new research activities in this domain. Background: VCoP have become a popular knowledge sharing mechanism for both individuals and organizations. Their evaluation process is complex; however, it is recognized as an essential means to provide evidences of community effectiveness. Moreover, VCoP have introduced additional features to face to face Communities of Practice (CoP) that need to be taken into account in evaluation processes, such as geographical dispersion. The fact that VCoP rely on Information and Communication Technologies (ICT) to execute their practices as well as storing artifacts virtually makes more consistent data analysis possible; thus, the evaluation process can apply automatic data gathering and analysis. Methodology: A systematic mapping study, based on five research questions, was carried out in order to analyze existing studies about VCoP evaluation methods and frameworks. The mapping included searching five research databases resulting in the selection of 1,417 papers over which a formal analysis process was applied. This process led to the preliminary selection of 39 primary studies for complete reading. After reading them, we select 28 relevant primary studies from which data was extracted and synthesized to answer the proposed research questions. Contribution: The authors of the primary studies analyzed along this systematic mapping propose a set of methods and strategies for evaluating VCoP, such as frameworks, processes and maturity models. Our main contribution is the identification of some research gaps present in the body of studies, in order to stimulate projects that can improve VCoP evaluation methods and support its important role in social learning. Findings: The systematic mapping led to the conclusion that most of the approaches for VCoP evaluation do not consider the combination of data structured and unstructured metrics. In addition, there is a lack of guidelines to support community operators’ actions based on evaluation metrics.


2014 ◽  
Vol 56 (10) ◽  
pp. 1167-1182 ◽  
Author(s):  
Marc Oriol ◽  
Jordi Marco ◽  
Xavier Franch

2021 ◽  
Vol 22 (13) ◽  
pp. 7238
Author(s):  
Wojciech Snoch ◽  
Dawid Wnuk ◽  
Tomasz Witko ◽  
Jakub Staroń ◽  
Andrzej J. Bojarski ◽  
...  

Cancer is one of the deadliest illness globally. Searching for new solutions in cancer treatments is essential because commonly used mixed, targeted and personalized therapies are sometimes not sufficient or are too expensive for common patients. Sugar fatty acid esters (SFAEs) are already well-known as promising candidates for an alternative medical tool. The manuscript brings the reader closer to methods of obtaining various SFAEs using combined biological, chemical and enzymatic methods. It presents how modification of SFAE’s hydrophobic chains can influence their cytotoxicity against human skin melanoma and prostate cancer cell lines. The compound’s cytotoxicity was determined by an MTT assay, which followed an assessment of SFAEs’ potential metastatic properties in concentrations below IC50 values. Despite relatively high IC50 values (63.3–1737.6 μM) of the newly synthesized SFAE, they can compete with other sugar esters already described in the literature. The chosen bioactives caused low polymerization of microtubules and the depolymerization of actin filaments in nontoxic levels, which suggest an apoptotic rather than metastatic process. Altogether, cancer cells showed no propensity for metastasis after treating them with SFAE. They confirmed that lactose-based compounds seem the most promising surfactants among tested sugar esters. This manuscript creates a benchmark for creation of novel anticancer agents based on 3-hydroxylated fatty acids of bacterial origin.


Author(s):  
Wajdi Aljedaani ◽  
Anthony Peruma ◽  
Ahmed Aljohani ◽  
Mazen Alotaibi ◽  
Mohamed Wiem Mkaouer ◽  
...  

2021 ◽  
Author(s):  
Tasnim M. A. Zayet ◽  
Maizatul Akmar Ismail ◽  
Kasturi Dewi Varathan ◽  
Rafidah M. D. Noor ◽  
Hui Na Chua ◽  
...  

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